The big question is what can be done to combat neuroinflammation
Same thing as combating any inflammation: supplements, lifestyle, food, medications (steroids), etc. Dr Mariano is all about focusing first on the positive feedback loop between norepinephrine and inflammation and decreasing the size of this loop through the changes mentioned above. This is why he recommends a supplement soup of antiinflammatory supplements, such as quercetin, vitamin A, vitamin E, krill oil, probiotics, etc. The brain-gut axis is also part of the deal, and probiotics help balance gut bacteria, and excessive bad bacteria can cause intestinal permeability, leading to "leaky brain", which leads to depression (this a paraphrase of what Chris Kresser has said).
The late Rich van Konynenburg theorized
that glutathione depletion from methylation problems is the main factor in chronic fatigue; glutathione is enormously antiinflammatory. Insufficient cortisol can also allow for inflammation to run amok.
With regard to diet, cutting out white flour, sugar, and gluten (which can be hard on the gut for anyone, not just folks with Celiac's or a food allergy) can be a game changer by itself, given especially the first two's massive inflammation impact.
So there's clearly a lot you can do to decrease inflammation.