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Author Topic: Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomye  (Read 3653 times)

Sighalot

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Thoughts on this? could a neuroinflammation have a LH and/or FSH lowering effect?

http://jnm.snmjournals.org/content/55/6/945.long

PeakT

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Thoughts on this? could a neuroinflammation have a LH and/or FSH lowering effect?

http://jnm.snmjournals.org/content/55/6/945.long

This is very interesting!  As I have mentioned on here many times, inflammation and depression often go together as well.  I would guess superbugs, lifestyles, toxins and heavy metals will all be implicated.
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And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Sighalot

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The big question is what can be done to combat neuroinflammation

cujet

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The big question is what can be done to combat neuroinflammation

Steroids may be the only viable solution.

I have Hashimoto's. Many people are unaware of the full extent of the damage Hashimoto's is capable of. Thyroid destruction, parathyroid destruction, RA joint destruction, and yes, encephalopathy, including spinal and brain.

It seems to be very responsive to steroids.
58 years old
Autoimmune Hashimoto's, near zero natural T production
Cause: severe mononucleosis in my early 30's
Weight 235 and climbing despite eating far less
Height 5' 10"
180mg NPthyroid (natural desiccated pigs thyroid)
Labs (Oct 2017) , my T=730, TSH 0.03, T3+T4 mid-range normal.
Prednisone 10mg/day (no ACTH, dangerously low cortisol)
 
10% compounded creme. T=725, which feels just right.

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Kierkegaard

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The big question is what can be done to combat neuroinflammation

Same thing as combating any inflammation: supplements, lifestyle, food, medications (steroids), etc.  Dr Mariano is all about focusing first on the positive feedback loop between norepinephrine and inflammation and decreasing the size of this loop through the changes mentioned above.  This is why he recommends a supplement soup of antiinflammatory supplements, such as quercetin, vitamin A, vitamin E, krill oil, probiotics, etc.  The brain-gut axis is also part of the deal, and probiotics help balance gut bacteria, and excessive bad bacteria can cause intestinal permeability, leading to "leaky brain", which leads to depression (this a paraphrase of what Chris Kresser has said).

The late Rich van Konynenburg theorized that glutathione depletion from methylation problems is the main factor in chronic fatigue; glutathione is enormously antiinflammatory.  Insufficient cortisol can also allow for inflammation to run amok.

With regard to diet, cutting out white flour, sugar, and gluten (which can be hard on the gut for anyone, not just folks with Celiac's or a food allergy) can be a game changer by itself, given especially the first two's massive inflammation impact.

So there's clearly a lot you can do to decrease inflammation. 
"The same thing that makes you live can kill you in the end." -- Neil Young

March 2014: Dx low T (158ng/dl)
September 2015: Dx hypothyroidism, other adrenal hypofunction
2016: chronic fatigue, unspecified

Depression and anxiety guide: http://www.peaktestosterone.com/Help_Anxiety_Depression

PeakT

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The big question is what can be done to combat neuroinflammation

I've told this story before, but I had crushing fatigue and achiness in my low T days.  I could barely keep my eyes open much of the day.  And what I read was that you could diagnose fibromyalgia by pain points on the body:  I had extreme tenderness at all those points.  So I don't know whether I really had CFS or fibromyalgia, but whatever it was, it was just miserable.  And what cleared it up?  I started with cleaning up my diet and that helped.  Then TRT helped.

Of course, diet - I would argue a highly plant based diet is the best as you know - can lower inflammation, increase micronutrients and many more.  But why would TRT help?  Well, check this out:

http://www.peaktestosterone.com/testosterone_inflammation
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Sighalot

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Same thing as combating any inflammation: supplements, lifestyle, food, medications (steroids), etc.
The blood brain barrier makes it complicated, yesterday i searched on prednisolone and found  that less then 1% passes throu.

http://www.peaktestosterone.com/testosterone_inflammation
seems i only get worse with increased T :/
« Last Edit: January 04, 2017, 11:52:48 pm by Sighalot »

PeakT

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Same thing as combating any inflammation: supplements, lifestyle, food, medications (steroids), etc.
The blood brain barrier makes it complicated, yesterday i searched on prednisolone and found  that less then 1% passes throu.

http://www.peaktestosterone.com/testosterone_inflammation
seems i only get worse with increased T :/

So you feel like you have the above?
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Peak Testosterone Forum