Progesterone and DHT

[PakMan]

It is well known that Progesterone inhibits 5 alpha-reductase thus lowering DHT but is the converse also true? Does DHT effect progesterone in any way?

[HRT Guru]

First Ive heard of this Progesterone inhibiting 5AR activity

[53chevy]

First I've heard of it too but I haven't specifically researched it either.

[Cataceous]

Effects of sex steroids on skin 5 alpha-reductase activity in vitro.

... We conclude that progesterone and the 19-nor-derivatives inhibit 5 alpha-reductase activity at high doses, whereas medroxyprogesterone acetate does not. ...

[53chevy]

So once again it's dose dependent.

[PeakT]

So once again it's dose dependent.

Yeah, but it has been widely talked about on the steroid forums.  Example:

http://www.uk-muscle.co.uk/topic/17030-progesterone-and-men/

And, if you really want to understand the underlying pathways of progesterone, check out Dr. Mariano's usual off the cuff but encyclopedic summary of the subject:

https://thinksteroids.com/community/threads/dr-mariano-elevated-progesterone.134269139/

[Boxcar]

I have seen progesterone cream marketed as a hair loss treatment, which seems like a problem waiting to happen.  Even the guys on here who like progesterone, seem to have a narrow range for where they feel good with it.

[53chevy]

It's just like with any other hormone, you need the right amount. And according to what Mariano says prog could be like supplementing with preg, you don't really know which path it's gonna take until you try it. Luckily for me it brings my cortisol up where it should be and gives me back morning wood, not real strong but at least it's there. On the other hand preg seems to go straight to e with me. Once again we are all highly individual.