I have seen this topic mentioned in the past, but with my specific situation, I'm not finding any good direction to follow. So, I started TRT two and a half years ago. Before starting TRT, my libido wasn't terrible, and to be honest it was probably better than it is now. I am currently, and have been receiving 250 mg of Testosterone Cypionate weekly, for about a year now. I started to notice a significant decline in libido probably about 4 months ago. My libido hasn't been what I would consider "good" for at least 5 years. I told my TRT doctor, and they did some labwork a few weeks ago. Here are my most recent labs, these are the only ones that I have: TT: 952. FT: 21. Estradiol:54. PSA: 1.7. My TRT doctor prescribed me .50 mg of Anastrozole weekly, for the elevated E2. It doesnt seen to affect my libido, but I have noticed a slight bit more irritability and aggresion when using it. I'm not sure if it's relevant, but I had also visited my PCP about three weeks ago for a yearly routine check-up. Here are my labs done then: Fasting blood glucose: 84. TSH: 1.9. My blood pressure, cholesterol, and my liver enzymes were all "very good". I have no idea what else to check. I have seen some mention of cortisol, and prolactin, but I have absolutely none of the symptoms of either of these imbalances, except of course the lack of a libido. I should also note, that since December of last year I have lost exactly 50 pounds of FAT. I did this purposely, and this wasn't from being sick or anything else. I started off weighing 253 pounds, @ 29 percent body fat. I currently weigh 203 pounds, @ 12 percent body fat. I did not use any chemicals, pharmaceuticals, or extreme caloric deficient methods. I simply reduced the amount I was eating, made better food choices, and I supplemented with apple cider vinegar, a good multivitamin, a multimineral, digestive enzymes, and a good liver support supplement( I did this because last fall my PCP told me I had fatty liver, and it was caused from eating too many processed foods).