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Author Topic: Why I can get an erection with Milk thistle  (Read 3577 times)

Poolguy

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Why I can get an erection with Milk thistle
« on: July 02, 2017, 03:29:22 am »
Hello I have ED all my test are normal but even Viagra or Cialis does not work.

When I started taking milk twisle a month ago they started to work, and I even can get erections and have intercorse without Viagra.

What efect can milk thistle have on me?

PeakT

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Re: Why I can get an erection with Milk thistle
« Reply #1 on: July 02, 2017, 08:42:29 am »
Hello I have ED all my test are normal but even Viagra or Cialis does not work.

When I started taking milk twisle a month ago they started to work, and I even can get erections and have intercorse without Viagra.

What efect can milk thistle have on me?

I would guess it centers around cytochrome activity:

https://www.ncbi.nlm.nih.gov/pubmed/11038151

"Treatment with silymarin (0.1 and 0.25 mM) significantly reduced the activity of CYP3A4 enzyme (by 50 and 100%, respectively) as determined by the formation of 6-beta-hydroxy testosterone and the activity of uridine diphosphoglucuronosyl transferase (UGT1A6/9) (by 65 and 100%, respectively) as measured by the formation of 4-methylumbelliferone glucuronide."

https://www.ncbi.nlm.nih.gov/pubmed/15637532

"Negligible competitive inhibition of CYP3A was observed in vitro. Mechanism-based inhibition of CYP3A was detected, albeit with a low potency. In human hepatocytes, exposure to 1 micromol/L or greater of tadalafil resulted in increased CYP3A protein expression; "

The reason that I believe it's 3A4 is because of the likely pomegranate Cialis interaction that has been reported.  Check this out for example:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355694/

"After oral administration, sildenafil is rapidly absorbed and the bioavailability reaches around 40% only due to extensive first-pass metabolism. This is also influenced by age of the patient and liver and kidney function. Warrington et al. reported that about 79% of the intrinsic clearance of sildenafil is attributable to cytochrome P450 (CYP) 3A4 and remaining to CYP2C9."
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And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program.aspx
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: Why I can get an erection with Milk thistle
« Reply #1 on: July 02, 2017, 08:42:29 am »


vvs1

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Re: Why I can get an erection with Milk thistle
« Reply #2 on: July 02, 2017, 10:00:46 am »
Does milk thistle increase or decrease shbg?

Poolguy

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Re: Why I can get an erection with Milk thistle
« Reply #3 on: July 02, 2017, 10:24:41 am »
Milk thistle decrease Shbg, and my test before I started taking milk thistle showed shbg to be low normal

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Re: Why I can get an erection with Milk thistle
« Reply #3 on: July 02, 2017, 10:24:41 am »


PeakT

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Re: Why I can get an erection with Milk thistle
« Reply #4 on: July 02, 2017, 08:07:19 pm »
Milk thistle decrease Shbg, and my test before I started taking milk thistle showed shbg to be low normal

Yes, by what percentage?  Unless it is making a dramatic reduction, you're not going to be able to "feel it" imo.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program.aspx
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Poolguy

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Re: Why I can get an erection with Milk thistle
« Reply #5 on: July 03, 2017, 04:08:35 am »
I don't know by how much it lowers shbg or why it helps me. But I am glad that something is helping me out.

Even if I just take milk thistle and no Viagra for days I can still get it up.
But is still not like it use to be, if I don't like something it goes limp but it will get back up. And taking Viagra just makes my erection a bit stronger not by much

PakMan

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Re: Why I can get an erection with Milk thistle
« Reply #6 on: July 03, 2017, 04:41:36 am »
Hello I have ED all my test are normal but even Viagra or Cialis does not work.

When I started taking milk twisle a month ago they started to work, and I even can get erections and have intercorse without Viagra.

What efect can milk thistle have on me?

I would guess it centers around cytochrome activity:

https://www.ncbi.nlm.nih.gov/pubmed/11038151

"Treatment with silymarin (0.1 and 0.25 mM) significantly reduced the activity of CYP3A4 enzyme (by 50 and 100%, respectively) as determined by the formation of 6-beta-hydroxy testosterone and the activity of uridine diphosphoglucuronosyl transferase (UGT1A6/9) (by 65 and 100%, respectively) as measured by the formation of 4-methylumbelliferone glucuronide."

https://www.ncbi.nlm.nih.gov/pubmed/15637532

"Negligible competitive inhibition of CYP3A was observed in vitro. Mechanism-based inhibition of CYP3A was detected, albeit with a low potency. In human hepatocytes, exposure to 1 micromol/L or greater of tadalafil resulted in increased CYP3A protein expression; "

The reason that I believe it's 3A4 is because of the likely pomegranate Cialis interaction that has been reported.  Check this out for example:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355694/

"After oral administration, sildenafil is rapidly absorbed and the bioavailability reaches around 40% only due to extensive first-pass metabolism. This is also influenced by age of the patient and liver and kidney function. Warrington et al. reported that about 79% of the intrinsic clearance of sildenafil is attributable to cytochrome P450 (CYP) 3A4 and remaining to CYP2C9."

But why does inhibiting CYP3A4 help with erections? He says its working even without viagra.
Age: 46, HT: 5' 7'', WT: 75 kg

Jan 16 to Oct 16 - Test Enanthate (35mg 2x/week)
Oct 16 to Feb 17 - HCG (500iu 2x/Week)
Feb 17 - Test Propionate (25mg only 2 injections 4 days apart)
Aug 2017 onwards (Astaxanthin + other oils, supplements)
Dec 2017 Low dose TRT (25 mg twice a week)
Nothing from Jan 1, 2019

21/08/2017 8:10 PM
Total T = 271 ng/dl  (Range 160 - 726)
LH = 5.15 mIU/ml  (Range 0.8 - 7.6)

Poolguy

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Re: Why I can get an erection with Milk thistle
« Reply #7 on: July 04, 2017, 02:45:40 am »
Even with Milk thistle working at this point erection is not like it used to be reliable and strong, I am thinking of trying a simple Testosterone cycle to see if it helps with my ED
« Last Edit: July 04, 2017, 02:47:20 am by Poolguy »

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Re: Why I can get an erection with Milk thistle
« Reply #7 on: July 04, 2017, 02:45:40 am »