Yeah, that's pretty beefy. First of all, let me say that reading about SHBG will give you a headache. It is very involved and if you see someone with pat formulas, I assure they don't know what they are talking about.
First of all, lower SHBG means less testosterone bound and thus more testosterone to work its magic, right? Studies have actually shown this, kind of. Notice this statement by one set of researchers:
"Results of in vitro experiments indicate that with increasing concentrations of SHBG, testosterone (T) is preferentially bound to SHBG in comparison with estradiol (E2). In these studies, the ratio of non-SHBG-bound E2 (non-SHBG-E2) to non-SHBG-T increased with increasing levels of SHBG.
SHBG has consequently been regarded as an estrogen amplifier."
However, the authors went to verify this and found a counterintuitive result:
"Therefore, we conclude that in eugonadal men, higher SHBG levels are associated with lower levels of non-SHBG-E2 but
slightly higher levels of non-SHBG-T. This means that SHBG cannot be regarded as an estrogen amplifier in eugonadal men."
Furthermore, lower SHBG is associated with many disease states and higher SHBG with solid insulin sensitivity.
But I have a couple of basic questions first:
--Are you on HRT?
--What is your age?
The reason I am asking about the latter is that if you are a senior, which is unlikely based on your post, and you have low estradiol and high SHBG, you are at increased risk for fractures:
http://www.ncbi.nlm.nih.gov/pubmed/18518773
