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Author Topic: High T / High SHBG  (Read 6875 times)

instantk

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High T / High SHBG
« on: April 21, 2013, 02:50:47 pm »
Got new set of labs...
Testosterone was over 1000 but SHBG was 64

normally my T averages around 500-600 and SHBG is around 35

thoughts?

IT would be real nice to maintain that high T but bring down SHBG some

PeakT

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Re: High T / High SHBG
« Reply #1 on: April 21, 2013, 07:49:03 pm »
Yeah, that's pretty beefy.  First of all, let me say that reading about SHBG will give you a headache.  It is very involved and if you see someone with pat formulas, I assure they don't know what they are talking about.

First of all, lower SHBG means less testosterone bound and thus more testosterone to work its magic, right?  Studies have actually shown this, kind of.  Notice this statement by one set of researchers:

"Results of in vitro experiments indicate that with increasing concentrations of SHBG, testosterone (T) is preferentially bound to SHBG in comparison with estradiol (E2). In these studies, the ratio of non-SHBG-bound E2 (non-SHBG-E2) to non-SHBG-T increased with increasing levels of SHBG. SHBG has consequently been regarded as an estrogen amplifier."

However, the authors went to verify this and found a counterintuitive result:

"Therefore, we conclude that in eugonadal men, higher SHBG levels are associated with lower levels of non-SHBG-E2 but slightly higher levels of non-SHBG-T. This means that SHBG cannot be regarded as an estrogen amplifier in eugonadal men."

Furthermore, lower SHBG is associated with many disease states and higher SHBG with solid insulin sensitivity.

But I have a couple of basic questions first: 

--Are you on HRT?

--What is your age?

The reason I am asking about the latter is that if you are a senior, which is unlikely based on your post, and you have low estradiol and high SHBG, you are at increased risk for fractures:

http://www.ncbi.nlm.nih.gov/pubmed/18518773
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: High T / High SHBG
« Reply #1 on: April 21, 2013, 07:49:03 pm »


instantk

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Re: High T / High SHBG
« Reply #2 on: April 21, 2013, 08:00:53 pm »
age 29, i take low dosage clomid 12.5mg EOD

PeakT

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Re: High T / High SHBG
« Reply #3 on: April 21, 2013, 08:08:55 pm »
age 29, i take low dosage clomid 12.5mg EOD

Ahh!  Well, this just comes with the territory I'm afraid:

http://www.ncbi.nlm.nih.gov/pubmed/6797955
"The effect of clomiphene citrate on sex hormone binding globulin in normospermic and oligozoospermic men"

"SHBG concentration rose from 38.1 +/- 18.3 to 54.3 +/- 16.0 nmol/l..."
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: High T / High SHBG
« Reply #3 on: April 21, 2013, 08:08:55 pm »


instantk

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Re: High T / High SHBG
« Reply #4 on: April 21, 2013, 08:17:38 pm »
I should give more history, I have been on /off clomid for a few years (experimented with T gel and hcg)

I don't think clomid is the sole reason behind my high Testosterone and SHBG... My newest addition was LDN http://www.lowdosenaltrexone.org/
I didnt think LDN would have such a profound effect on my T levels and SHBG until i found this
I started LDN several weeks ago because of my autoimmune disease / hashimotos
Quote




There are widespread reports of increased energy and improved quality of sleep (with more vivid dreams) from people on the internet who have reported their experiences using LDN to treat various diseases. Another interesting phenomenon reported by men is an increase in morning erections, and although the cause of this is not exactly known it may have something to do with an increase in testosterone levels.
 
I am not sure if there is a substantial connection between LDN therapy and testosterone, but naltrexone definitely has the potential to influence the hypothalamic pituitary testicular axis (HPTA). Many studies have shown increases in testosterone levels in animals (including humans), as well as increases in sexual activity and libido with administration of naltrexone. Naltrexone increases the release of GnRH from the hypothalamus, and GnRH is the signal that causes the pituitary to release LH and FSH, which of course then increases testosterone and sperm production in the testes. Opiate receptors have an important regulatory role in GnRH production, and apparently receptor blockade results in increased output of GnRH. Of course LDN therapy only results in temporary opiate receptor blockade, so any up-regulation of the HPTA is probably also transient. Whether this nighttime spike in HPTA activity is enough to cause an increase in morning “wood” is debatable, and its possible that some other neuroendocrinological phenomenon is at play. http://patrickarnoldblog.com/interes...g-drug-part-3/


Having said that only time and more routine blood work will tell the tale

PeakT

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Re: High T / High SHBG
« Reply #5 on: April 21, 2013, 09:11:56 pm »
Hypothyroidism is associated with rising SHBG.  Haven't studied specifically Hashimoto's.  If you pull any studies or info, let us know...
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

instantk

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Re: High T / High SHBG
« Reply #6 on: April 21, 2013, 10:00:47 pm »
I have hypothyroidism / hashimotos i take thyroid meds

but i only noticed a sharp increase in total T and shbg soon after i started LDN

shbg and total T have usually been constant for most of my labs

my main focus is to decrease SHBG to my normal range of 35-45 while holding a high Total T,, that would be ideal

PeakT

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Re: High T / High SHBG
« Reply #7 on: April 21, 2013, 10:23:39 pm »
I have hypothyroidism / hashimotos i take thyroid meds

but i only noticed a sharp increase in total T and shbg soon after i started LDN

shbg and total T have usually been constant for most of my labs

my main focus is to decrease SHBG to my normal range of 35-45 while holding a high Total T,, that would be ideal

I don't know specifically about that med, but it looks like potent stuff.  I know, for example, that dopamine agonists can really raise SHBG:

http://pubget.com/paper/1813034/The_levels_of_pituitary_testicular_axis_hormones_and_SHBG_in_active_acromegaly_following_bromocriptine_treatment
"The levels of pituitary-testicular axis hormones and SHBG in active acromegaly following bromocriptine treatment"

This study would probably answer the question, but I can't get my hands on it...

http://jcem.endojournals.org/content/90/1/203.short
« Last Edit: April 21, 2013, 10:25:49 pm by PeakT »
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

instantk

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Re: High T / High SHBG
« Reply #8 on: April 21, 2013, 11:32:24 pm »
I have noticed better REM sleep erections since starting LDN

I know DANAZOL lowers SHBG but usually lowers Total T, therefore your left with the same Free T

PeakT

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Re: High T / High SHBG
« Reply #9 on: April 22, 2013, 01:07:42 am »

I know DANAZOL lowers SHBG but usually lowers Total T, therefore your left with the same Free T

This looks like a completely different animal. 
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Peak Testosterone Forum

Re: High T / High SHBG
« Reply #9 on: April 22, 2013, 01:07:42 am »