However, it's important to understand that the endocrine system is an active system and replacing any of the functions with static pharmaceuticals is not likely to help otherwise healthy people.
Not sure what you went, but I can't help think of Dr. Dzugan's work, where he dropped cholesterol by 35% by adding "static pharmaceuticals". His approach was different - more anti-aging in the sense that he worked with a suite of hormones and not just T/E2 - but his research makes it appear likely that high cholesterol and lipids in many men is because they have lower hormones levels that is their body's natural youthful equilibrium point. The point in my mind is that he worked on all the hormones and achieved results much better than a statin. It's a shame imo that his work has not received more attention. How many guys on this board are walking with artificially high lipids and putting on additional plaque because of it?