Quantcast

Author Topic: Non Suppression of LH and FSH For Primary Hypogonadism  (Read 2773 times)

doin it

  • Sr. Member
  • ****
  • Posts: 361
    • View Profile
Re: Non Suppression of LH and FSH For Primary Hypogonadism
« Reply #15 on: November 18, 2017, 08:24:32 am »

Re my post above pertaining to biochemical produced by the testicles.

Wonder how many are affected by LH and FSH ?

 https://www.google.com/amp/s/www.newscientist.com/article/dn26506-amaze-balls-testicles-site-of-most-diverse-proteins/amp/

The proteins in our cells and tissues are responsible for everything from repair and maintenance to the production of signalling chemicals. You might expect that the brain, being our most sophisticated organ, would produce the widest array of proteins. But while the brain hosts 318 unique proteins that we know of, testicles are home to 999.

It is one of the surprising messages from the latest, most comprehensive version of the Human Protein Atlas “proteome” – an inventory of all the proteins produced in the human body. Launched this week onproteinatlas.org, the atlas represents a decade of work in 13 laboratories, led by Mathias Uhlén of the Royal Institute of Technology in Stockholm, Sweden.

 http://www.proteinatlas.org/

“It’s all very well knowing all our genes but at the end of the day, all human disease and biology stem from the proteins – the building blocks of humans,” says Uhlén. “What we’ve produced is like a Gray’s Anatomy for proteins.”

The atlas reveals for the first time where most of these proteins are made and what they are doing in our bodies.

Ausguy222

  • Full Member
  • ***
  • Posts: 108
    • View Profile
Re: Non Suppression of LH and FSH For Primary Hypogonadism
« Reply #16 on: November 19, 2017, 04:04:43 am »

I suppose I'm talking of a potential instance where LH is screaming super high to make T, but the Testes don't, so after time LH gives up. Testes are already dead. LH then goes dead.

That's kind of a pituitary exhaustion theory.  I haven't read of any evidence of that.

See I wonder if it's more of a broken feedback loop, rather than the pituitary giving up against its volition. Something actively *telling it* that it doesn't need to, and that the low T via the dead downstairs is normal, so LH drops voluntarily.

Peak Testosterone Forum

Re: Non Suppression of LH and FSH For Primary Hypogonadism
« Reply #16 on: November 19, 2017, 04:04:43 am »


doin it

  • Sr. Member
  • ****
  • Posts: 361
    • View Profile
Re: Non Suppression of LH and FSH For Primary Hypogonadism
« Reply #17 on: November 19, 2017, 06:34:23 am »

My experience is that LH (HP) never gives up, just keeps on getting higher and higher (before TRT), hammering away on the testicles.  But I am Primary (probably age related).  TRT has started to reduce both FSH and LH, so apparently the (HPG) feedback loop still works.

Peak Testosterone Forum

Re: Non Suppression of LH and FSH For Primary Hypogonadism
« Reply #17 on: November 19, 2017, 06:34:23 am »