I did Spectracell and found a few slight deficiencies, but supplementing with them (e.g., pantothenic acid) had no noticeable change in my symptoms. Worth noting that there's some disagreement about the validity of Spectracell (not sure if I'm on this train). Chris Kresser (who came out with a new book a month or so ago on functional medicine which looks really good) as usual has some interesting thoughts:
"I prefer the ION and the NutrEval. It’s difficult to test for nutrient status, because each nutrient resides in a different place, like different tissues or is represented differently in the body. For example, magnesium, less than one-half of 1% of magnesium is in the serum. So when you test serum magnesium, you’re getting a level—you’re only testing for 0.5% of the total body storage of magnesium. There is some correlation between serum magnesium and total body magnesium, but it’s certainly possible to have normal serum magnesium and have low body stores. It may even be possible to have low serum magnesium and normal body stores, although I think that’s less likely. With each nutrient there are certain things to be aware of, in terms of how it’s best tested. I’m not sure that the SpectraCell really takes that into account. I prefer the NutrEval because they’re often using organic acids or amino acids where—there are cycles in the body that require enzymes to complete. Each of those enzymes requires certain nutrients to function properly. So if you see a build-up of a certain organic acid, that indicates that that cycle wasn’t able to complete, which means that the enzyme needed in that cycle didn’t have the cofactors that it requires to make the conversion. Then you can kind of put all that together, and you can get information about nutrient deficiency. That way, that might be more accurate, because it’s reflecting actual usage of that nutrient in the body. The other thing is that method of testing often tests for the most active form of the nutrient that’s used in those enzymatic reactions, rather than the precursor forms of the nutrient. For example, urinary methylmalonic acid (MMA) is the best way to test for adenosylcobalamin or methylcobalamin deficiency, which are the active forms of B12, whereas serum B12 actually measures all of the total cobalamins, including the less active forms of B12, like cyanocobalamin. So you’re getting different information, depending on the different ways that you test."
Then one of his more savvy commenters said this:
"Just an FYI – the Spectracell test is not a serum test in the way that you describe serum tests. It does rely on a blood draw, but what the lab does it to isolate lymphocytes (average lifespan 4-6 months), and then place them into varying “ideal growth” solutions that are each missing a different micronutrient. The lab then compares growth rates of those cells against benchmarks, which allows one to see if the cells have enough of a particular micronutrient stored and available (intracellularly) to grow without it being present in the solution. This process necessarily measures the active form of the micronutrient, because it relies on what’s actually contained inside the cell."
Also worth noting that Spectracell (at least for me) only measured around five or so amino acids for whatever reason.