I tried topical DHT, to no effect. Diet seems to have some impact, although it is inconsistent. There is some research indicating that IGF-1 and insulin activate androgen receptors. This is from cancer research, so I don't know if it is applicable here. But there is some suggestion that growth hormone and IGF-1 are associated with a greater sense of well-being.
Has your muscle mass changed over time? You mention being slightly pre-diabetic, so I wonder if there is something metabolic going on.
I am also low in DHEA, but anything over 5 mg starts to give me sleep issues. So I plan to give topical DHEA a shot. In addition to helping with mood, DHEA is also supposed to have metabolic benefits. I am also getting cortisol checked out.
Yeah i had good muscle mass the first 2 years on the gels i probably added +20 pounds of muscle to my frame. Now I am back to my genetic set point and to me it seems my body is just like nope even if your T level is xyz we are only going to use yxz and it barely feels like im on anything.
I dont really care about the muscle mass part but the lack of energy and vitality and libido makes me scratch my head.
Also i ALWAYS used to feel HUNGRY almost RAVENOUS when i started TRT. And that feeling has gone away completely.
Its like my body isnt using the testosterone properly or something.
I post something about this every 6 months and no one has any real solutions and then i ignore it and just live my life.
But there has to be a reason this is happening. My endo said most guys can use the gels or injections longterm no problem.
I asked him about androgen resistance and he said its a possiblity but unlikely if it worked at the start to develop that later on.
I've already spent thousands of dollars flying out to see dr mariano and while he seemed like a nice guy and we tried some stuff, this still hasnt resolved.
So i really have no idea.
I guess I will try DHEA or PREG in ultra low doses and see if that has any benefits.