Author Topic: I think I crashed me E2. What can I do now? (Read 6962 times)

gimmeabreak · « **on:** February 20, 2018, 11:01:12 pm »

Im not 100 percent sure yet but I'm fairly certain I took too much arimidex and crashed my E2. I will be getting bloodwork on Thursday to confirm.

So I've been under a lot of stress lately and I think I accidentally took too much arimidex. I haven't felt this awful since before I started trt. I've never experienced brain fog like this. Feels like I have not slept in days even though I'm sleeping through the night. And I have a twitch in my left eye which is driving me absolutely crazy.

Just wondering in the event that it is a crash of E2, is there anything I can do to recover more quickly?

What kind of timeline am I looking at to bounce back?

Dr. John Crisler · « **Reply #1 on:** February 21, 2018, 02:35:32 am »

Most guys will jump right back up again....as if they just missed a dose of AI.

I have heard cases where someone more ominous occurred, and things never got right again. Dr. Shippen told me one time about a guy who took a single 1mg tablet of Arimidex, and was trashed for a very long time. It's similar to the dreaded Post Finasteride Syndrome (PFS). Perhaps some epigenetic effect.

But please rest assured, such cases are extremely rare.

Peak Testosterone Forum · « **Reply #1 on:** February 21, 2018, 02:35:32 am »

Mr.L · « **Reply #2 on:** February 21, 2018, 02:53:11 am »

Quote from: gimmeabreak on February 20, 2018, 11:01:12 pm

Im not 100 percent sure yet but I'm fairly certain I took too much arimidex and crashed my E2. I will be getting bloodwork on Thursday to confirm.

So I've been under a lot of stress lately and I think I accidentally took too much arimidex. I haven't felt this awful since before I started trt. I've never experienced brain fog like this. Feels like I have not slept in days even though I'm sleeping through the night. And I have a twitch in my left eye which is driving me absolutely crazy.

Just wondering in the event that it is a crash of E2, is there anything I can do to recover more quickly?

What kind of timeline am I looking at to bounce back?

Mine was down to 16. I know that isn't super low for everyone but it was for me. I felt terrible mentally and physically. Everything was an end of the world big deal and all of my joints hurt. I was told to simply DC the AI for one week and that was all it took. I felt better that week and was back to normal in less than 2. Then I started a lower dose. How did you end up taking too much? I have tried to take it to control symptoms but I have decided that I am not very good at knowing the difference between high and low E2. I guess some guys can but I just never know for sure and am constantly doubting myself. I have decided that a lab is the only way for me to know for sure what is going on with it. Good luck man.

gimmeabreak · « **Reply #3 on:** February 21, 2018, 03:02:21 am »

Quote from: Dr. John Crisler on February 21, 2018, 02:35:32 am

Most guys will jump right back up again....as if they just missed a dose of AI.

I have heard cases where someone more ominous occurred, and things never got right again. Dr. Shippen told me one time about a guy who took a single 1mg tablet of Arimidex, and was trashed for a very long time. It's similar to the dreaded Post Finasteride Syndrome (PFS). Perhaps some epigenetic effect.

But please rest assured, such cases are extremely rare.

Thanks for the reassurance Dr. Crisler. I’m going on day 6 of feeling like hell. Let’s hope it’s over soon!

Quote from: Mr.L on February 21, 2018, 02:53:11 am

Quote from: gimmeabreak on February 20, 2018, 11:01:12 pm
Im not 100 percent sure yet but I'm fairly certain I took too much arimidex and crashed my E2. I will be getting bloodwork on Thursday to confirm.

So I've been under a lot of stress lately and I think I accidentally took too much arimidex. I haven't felt this awful since before I started trt. I've never experienced brain fog like this. Feels like I have not slept in days even though I'm sleeping through the night. And I have a twitch in my left eye which is driving me absolutely crazy.

Just wondering in the event that it is a crash of E2, is there anything I can do to recover more quickly?

What kind of timeline am I looking at to bounce back?

Mine was down to 16. I know that isn't super low for everyone but it was for me. I felt terrible mentally and physically. Everything was an end of the world big deal and all of my joints hurt. I was told to simply DC the AI for one week and that was all it took. I felt better that week and was back to normal in less than 2. Then I started a lower dose. How did you end up taking too much? I have tried to take it to control symptoms but I have decided that I am not very good at knowing the difference between high and low E2. I guess some guys can but I just never know for sure and am constantly doubting myself. I have decided that a lab is the only way for me to know for sure what is going on with it. Good luck man.

I’ve been under a lot of stress lately and working absurd hours at work. I normally take my AI on the same day as my injections. I thought I forgot to take it so I took a second dose. I’m still not 100 percent sure but it’s the only thing I can think of. I haven’t felt this way since pre trt. It feels like I haven’t slept in days even though I’m sleeping every night. So hard to concentrate and no ambition to do anything right now. Just completely numb.

Peak Testosterone Forum · « **Reply #3 on:** February 21, 2018, 03:02:21 am »

Mr.L · « **Reply #4 on:** February 21, 2018, 03:24:26 am »

Quote from: gimmeabreak on February 21, 2018, 03:02:21 am

Quote from: Dr. John Crisler on February 21, 2018, 02:35:32 am
Most guys will jump right back up again....as if they just missed a dose of AI.

I have heard cases where someone more ominous occurred, and things never got right again. Dr. Shippen told me one time about a guy who took a single 1mg tablet of Arimidex, and was trashed for a very long time. It's similar to the dreaded Post Finasteride Syndrome (PFS). Perhaps some epigenetic effect.

But please rest assured, such cases are extremely rare.

Thanks for the reassurance Dr. Crisler. I’m going on day 6 of feeling like hell. Let’s hope it’s over soon!

Quote from: Mr.L on February 21, 2018, 02:53:11 am
Quote from: gimmeabreak on February 20, 2018, 11:01:12 pm
Im not 100 percent sure yet but I'm fairly certain I took too much arimidex and crashed my E2. I will be getting bloodwork on Thursday to confirm.

So I've been under a lot of stress lately and I think I accidentally took too much arimidex. I haven't felt this awful since before I started trt. I've never experienced brain fog like this. Feels like I have not slept in days even though I'm sleeping through the night. And I have a twitch in my left eye which is driving me absolutely crazy.

Just wondering in the event that it is a crash of E2, is there anything I can do to recover more quickly?

What kind of timeline am I looking at to bounce back?

Mine was down to 16. I know that isn't super low for everyone but it was for me. I felt terrible mentally and physically. Everything was an end of the world big deal and all of my joints hurt. I was told to simply DC the AI for one week and that was all it took. I felt better that week and was back to normal in less than 2. Then I started a lower dose. How did you end up taking too much? I have tried to take it to control symptoms but I have decided that I am not very good at knowing the difference between high and low E2. I guess some guys can but I just never know for sure and am constantly doubting myself. I have decided that a lab is the only way for me to know for sure what is going on with it. Good luck man.

I’ve been under a lot of stress lately and working absurd hours at work. I normally take my AI on the same day as my injections. I thought I forgot to take it so I took a second dose. I’m still not 100 percent sure but it’s the only thing I can think of. I haven’t felt this way since pre trt. It feels like I haven’t slept in days even though I’m sleeping every night. So hard to concentrate and no ambition to do anything right now. Just completely numb.

Yeah that sucks man. I wouldn't think one extra dose would drop you that low but I don't really know. I do know E2 and AIs can be tricky and frustrating though. Hopefully you get it figured out soon. It usually takes a week to get your lab results on the sensitive test so you will have to hold on for dear life.

Simeoni · « **Reply #5 on:** February 21, 2018, 09:26:09 am »

Your serum levels should bounce back in a matter of 1-2 weeks. From what Ive seen the low e2 symptoms might linger on a bit longer. Everyone is different but it might take as long as 4-8 weeks.

I suggest you keep your dose steady and do not take any drastic measures - like reintroducing an ai - without pulling labs first.

Quote from: gimmeabreak on February 20, 2018, 11:01:12 pm

Im not 100 percent sure yet but I'm fairly certain I took too much arimidex and crashed my E2. I will be getting bloodwork on Thursday to confirm.

So I've been under a lot of stress lately and I think I accidentally took too much arimidex. I haven't felt this awful since before I started trt. I've never experienced brain fog like this. Feels like I have not slept in days even though I'm sleeping through the night. And I have a twitch in my left eye which is driving me absolutely crazy.

Just wondering in the event that it is a crash of E2, is there anything I can do to recover more quickly?

What kind of timeline am I looking at to bounce back?

Krataios · « **Reply #6 on:** February 21, 2018, 11:30:04 am »

Quote from: gimmeabreak on February 20, 2018, 11:01:12 pm

Im not 100 percent sure yet but I'm fairly certain I took too much arimidex and crashed my E2. I will be getting bloodwork on Thursday to confirm.

So I've been under a lot of stress lately and I think I accidentally took too much arimidex. I haven't felt this awful since before I started trt. I've never experienced brain fog like this. Feels like I have not slept in days even though I'm sleeping through the night. And I have a twitch in my left eye which is driving me absolutely crazy.

Just wondering in the event that it is a crash of E2, is there anything I can do to recover more quickly?

What kind of timeline am I looking at to bounce back?

It takes me about a week to start feeling better. I thought high E2 was a nightmare untill I crashed my estrogen.

golfboy307 · « **Reply #7 on:** February 21, 2018, 03:23:43 pm »

It took me about 3 weeks to start feeling right again after a E2 crash...

gimmeabreak · « **Reply #8 on:** February 21, 2018, 03:26:57 pm »

Thanks for all the feed back everyone. I think I feel a little better today. Still foggy but not falling asleep at my desk right now.

jaydoe93 · « **Reply #9 on:** February 22, 2018, 06:37:15 pm »

Quote from: Dr. John Crisler on February 21, 2018, 02:35:32 am

Most guys will jump right back up again....as if they just missed a dose of AI.

I have heard cases where someone more ominous occurred, and things never got right again. Dr. Shippen told me one time about a guy who took a single 1mg tablet of Arimidex, and was trashed for a very long time. It's similar to the dreaded Post Finasteride Syndrome (PFS). Perhaps some epigenetic effect.

But please rest assured, such cases are extremely rare.

Can you please elaborate on this, Dr. Crisler? I am positive I am one of these guys. I will be talking about it with Dr. Saya in March.

jaydoe93 · « **Reply #10 on:** March 25, 2018, 09:46:24 pm »

anyone?

Joe Sixpack · « **Reply #11 on:** March 26, 2018, 12:40:54 am »

Quote from: jaydoe93 on March 25, 2018, 09:46:24 pm

anyone?

what are you questioning?

doin it · « **Reply #12 on:** March 26, 2018, 02:27:18 am »

Quote from: Joe Sixpack on March 26, 2018, 12:40:54 am

Quote from: jaydoe93 on March 25, 2018, 09:46:24 pm
anyone?
what are you questioning?

-------

Joe,
He is referring to Dr. John's post at the top of the thread.

Jay
Maybe look into reducing E2 metabolism.

http://www.drdebe.com/articles/safe-alternatives-to-estrogen-replacemen

"A number of natural compounds can slow the breakdown, and thus increase retention, of estrogen in the body. These include grapefruit, the B vitamin PABA, and the plant compound quercetin. The mineral boron has been shown to raise estrogen levels in postmenopausal women."

I think there may be other foods/supps that also do this.

Something else to look into are foods/supps that affect the P450 liver enzymes.
e.g.
Cytochrome P450 1A2 (CYP1A2) is responsible for the metabolism of estrogens and many exogenous compounds, including caffeine.

jaydoe93 · « **Reply #13 on:** March 26, 2018, 01:23:31 pm »

Quote from: doin it on March 26, 2018, 02:27:18 am

Quote from: Joe Sixpack on March 26, 2018, 12:40:54 am
Quote from: jaydoe93 on March 25, 2018, 09:46:24 pm
anyone?
what are you questioning?

-------

Joe,
He is referring to Dr. John's post at the top of the thread.

Jay
Maybe look into reducing E2 metabolism.

http://www.drdebe.com/articles/safe-alternatives-to-estrogen-replacemen

"A number of natural compounds can slow the breakdown, and thus increase retention, of estrogen in the body. These include grapefruit, the B vitamin PABA, and the plant compound quercetin. The mineral boron has been shown to raise estrogen levels in postmenopausal women."

I think there may be other foods/supps that also do this.

Something else to look into are foods/supps that affect the P450 liver enzymes.
e.g.
Cytochrome P450 1A2 (CYP1A2) is responsible for the metabolism of estrogens and many exogenous compounds, including caffeine.

Grapefruit is one of my favorite fruits. Before this happened to me I had at least one a day. Now I cannot eat it because it raises my estrogen and makes my situation much worse. I know it sounds bizarre but I am just reporting what happens. It is like my body no longer wants anything to do with Estrogen and reacts paradoxically to it.

Edit: I really hate typing this stuff out as it sounds impossible and like I am no idea what I am talking about. I would just like to add that I have used arimidex for 3 years previously without any problems. TRT wouldn't have been possible without it- I really liked this drug. So I am not bashing arimidex or blaming it. I think for a very rare amount of guys like myself unfortunately, misuse of it can cause serious problems. Not just a hormonal imbalance. But the ability for the receptor to fundamentally change the way it works.

I am on the same exact protocol I have always been on 100mg T cypionate a week, and do not feel a fraction like myself. I have even come off of TRT a few times and never felt any of the side effects I am dealing with right now.
T: 1006 (250-960)
E2: 35 (7-42)
SHBG: 33 (15-55)

I have come to believe that my situation and a few others resembles a phenomenon that happens in breast cancer cells. But clearly, I do not have breast cancer. I believe the same thing can happen in somatic cells. I have no receptor signaling despite having a pretty decent E2 level. Arimidex lowers my E2 but has no effect on my body. And increases of estrogen make me feel much worse. I described it to Dr. Saya as going through chemotherapy. And if you read peoples reports on chemo they report nausea, no appetite, severe hair loss, and anxiety. I get the same thing and I never had any of these symptoms in my life.
This would explain my situation well if it indeed happens in somatic cells.
http://www.pnas.org/content/pnas/108/47/18879.full.pdf

Joe Sixpack · « **Reply #14 on:** March 26, 2018, 11:33:46 pm »

Quote from: jaydoe93 on March 26, 2018, 01:23:31 pm

Grapefruit is one of my favorite fruits. Before this happened to me I had at least one a day. Now I cannot eat it because it raises my estrogen and makes my situation much worse. I know it sounds bizarre but I am just reporting what happens. It is like my body no longer wants anything to do with Estrogen and reacts paradoxically to it.

Edit: I really hate typing this stuff out as it sounds impossible and like I am no idea what I am talking about. I would just like to add that I have used arimidex for 3 years previously without any problems. TRT wouldn't have been possible without it- I really liked this drug. So I am not bashing arimidex or blaming it. I think for a very rare amount of guys like myself unfortunately, misuse of it can cause serious problems. Not just a hormonal imbalance. But the ability for the receptor to fundamentally change the way it works.

I am on the same exact protocol I have always been on 100mg T cypionate a week, and do not feel a fraction like myself. I have even come off of TRT a few times and never felt any of the side effects I am dealing with right now.
T: 1006 (250-960)
E2: 35 (7-42)
SHBG: 33 (15-55)

I have come to believe that my situation and a few others resembles a phenomenon that happens in breast cancer cells. But clearly, I do not have breast cancer. I believe the same thing can happen in somatic cells. I have no receptor signaling despite having a pretty decent E2 level. Arimidex lowers my E2 but has no effect on my body. And increases of estrogen make me feel much worse. I described it to Dr. Saya as going through chemotherapy. And if you read peoples reports on chemo they report nausea, no appetite, severe hair loss, and anxiety. I get the same thing and I never had any of these symptoms in my life.
This would explain my situation well if it indeed happens in somatic cells.
http://www.pnas.org/content/pnas/108/47/18879.full.pdf

That sounds awful.
Was there anything in particular that started your symptoms? Or did it just come on gradually and got to a point where you eventually noticed it over time?

Peak Testosterone Forum · « **Reply #14 on:** March 26, 2018, 11:33:46 pm »

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