Important note, that in your liver you have a total p450 number, which is the combine enzyme count of all differnt types of p450,s. different enzymes are designated by different letters, i.e p450j is responsible for alcohol metabolism, so if you drink alot p450j will be ellevated, which helps you build up alcohol tolerance, but lso diminishes your bodys ability to metabolize other things. It really underscores the importance of everything in moderation. It also is the reason some drugs are contraindicated because one drug can make another drug potentially more toxic due to the fluctuation in liver enzymes. At least thats the way i remeber it from college 20 years ago.