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Author Topic: My Wifes low T replacement Journey  (Read 1758 times)

Flyingfool

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My Wifes low T replacement Journey
« on: October 31, 2018, 09:41:37 am »


Some intital data:  Female, age 48 (in January she will be 49), perimenopause. Not physically active and is 5-4 and of 200 lbs.  Total T of 53 (2-45) and serum Free T of 4.3 (0.2-5)

Since there is no real place for women’s issue with Low T, I thought I would create this thread to document my wife’s journey with low T.

A brief history.  She has had a LONG journey with getting her Thyroid treated properly.  MANY years and several Doctors and she is finally pretty much optimized.  But even with this optimized, she still had many symptoms and lack of libido.  We had hoped these would be all remedied by her low thyroid.

When several symptoms remained, I started doing on-line research as to what that may be from.  She had her sex hormones tested as early as mid-July 2014.  And she had unmeasurable level of Testosterone (less than 20).  Several additional tests I think up to 3 over the following years also ALL showed her to have unmeasurable level of T.  Despite my continued pleas for her and her DR to do something about that.  Nothing was done.

When her thyroid was clearly about optimized, and the symptoms remained, we FINALLY convinced the Dr to do something about the T-Levels.  I believe this doctor has treated several men with low T, but I do not think he treated a single female.  So my wife may likely be one of the first, if not THE first.

As a result, he started VERY cautiously. He prescribed a compounded T cream at a very low dosage.  I can’t remember it was something like 0.5 or 1 Mcg per day.

Each successive test resulted in still zero measurable T level. Which corresponded to two or 3 increases in dosage of the T-Cream.

At this time we investigated going to see a true female hormone specialist.  The firm is Biobalance health based in St. Louis and Kansas City.  Watched a TON of healthcast videos, bought the doctors book (The Secret Female Hormone) by Kathy Maupin and Bret Newcomb.  I would HIGHLY recommend both the book and the archive of over 400 half hour video healthcast.  These cover both men and women’s health issues, mostly around hormones, but also other general health issues.

This investigation led to us setting up an appointment for my wife at Biobalance in St. Louis as it is “only” about 350 miles from us.  But she continued to use the T-cream.

I started seeing or noticing my wife losing weight with the T-cream.  In fact I noticed this before my wife did.  And she “wrote it off” as just normal weight fluctuation.  But I kept asking and eventually she did indicate that she was losing.

In prep for her biobalance appointment, the clinic required a significant battery of blood labs and ultrasounds etc.  A detailed health history survey etc.  Very though.

Part of the blood work of course retested for sex hormones.  And her T level FINALLY registered.  Total T was now above the range, but her free T was still only 4.3.  Yet at this point she had lost 14 lbs (she started out and was overweight/obese at over 200 lbs).  Still even with this low amount of T, and little to no change in lifestyle changes, she lost 14 Lbs (about 7% of her body weight)

Biobalance:

Her appointment was just yesterday 10/29/18

The appointment was outstanding.  The doctor took OVER an  hour with BOTH of us.  The Dr talks with and went over and confirmed symptoms and history.  The Doctor went over every blood test result. What was good, what was bad, where it “should” be and how they can help her get to that point.  They provided recommendations and why those recommendations were made, what they would expect to see as a result and how everything would progress.  This not only discussed the Sex hormones, but overall health. Diet, exercise. Changes to supplements, which supplements to stop, which to add, and which to change dosage etc.  Recommended books to read and specific supplements brands that they have had good luck with and having science to back up the quality and consistency, as the unregulated area of supplements means that some are great, and other brands not so much.  So that was great.

The result was that my wife was insulin resistant.  Her being overweight contributed to this as well as other things, Her blood sugar is also on the higher side etc.  This resulted in recommendation of Metformin prescription.  This should help the insulin resistance, along with the changes in diet and exercise program as well as getting Testosterone all should help her lose weight.  The Dr believes that Metformin may only be needed for a fairly short time, as once she loses weight and changes life styles her insulin resistance should reduce.  But this will be monitored.  But the goal is to eliminate this over time in maybe 6 months or so.

Wife also had bad liver enzymes and early indication of liver disease.  They also felt that fatty liver was probably the issue and again the loss of weight and visceral fat may get these back in line over time.

She was given Testosterone pellets along with Airimidex.  Unlike men, controlling estrogen is easier and more straight forward then men. Which is almost always recommended to NOT add an AI until you prove you need it.  Estrogen control is a bit easier in women it would seem.  There is more “margin for error” as women have so much more estrogen.  Also the idea along with DIM was prescribed to help change the estrogen from Estrone (E1), to more estradiol (E2).

The experience is that FREE T is really the only thing they concentrate on.  And the range they use for women to feel well is to have the free Testosterone to be I think 15 to 25.  My wife is only at 4.3,  So they want to at least more than TRIPLE her T level.

My wife has NEVER, EVER had a libido.  And the reports are that usually about 2 weeks after getting pellets, the women will go through a “honeymoon period”.  This is due to the testosterone receptors having been starved of T when suddenly getting testosterone, they women will be EXTREMELY horny. This is a one time event. Not every woman experiences it, but most do. This honeymoon period is pretty short lived lasting only a few days!

I CANNOT WAIT for this time.  IF it happens.  I am a bit dubious that it will happen due to the fact that my wife so slowly built up some Testosterone with the T-Cream that her receptors will have had a chance to adjust and she wo n’t experience this phase.  I pray this is not true.  After 28+ years of marriage to a wife with zero libido I have always hoped and prayed for a wife who would be interested and passionate about sex!  Time will tell. My wife just cannot believe this will happen to her, because in her own words “This is soooo much NOT like “me, that I just can’t see myself being like that.”

My wife is super excited. She cannot wait for “the new her” to come alive. She also cannot imagine herself 40 lbs lighter as she has ALWAYS, ALWAYS struggled with her weight. And no matter how hard she worked or changed diet etc it always resulted in nothing!  So to believe that she has a means to actually have her body work and lose weight given diet and exercise and medicine etc has her extremely excited.  She also is looking forward to better mood, better health and immunity etc. She just cannot imagine herself healthy and happy. Something she also has struggled with her whole life.

I can’t think of anything else at the moment to add. But I wanted to have a place to document her journey. And maybe some of you men out there have a wife that similarly has, or you suspect has a low T problem, but the Doctors won’t do a dang thing about it!  or eve test for testosterone in women!  I hope this will document a success story that other can use to inspire their wives to become their own best advocate and seek treatment.

Ultimately, I would love to have this forum set up a separate folder for female low T issues.  As I think it is extremely important issue that is TOTALLY under diagnosed.  There are a LOT of women, and marriages that are suffering as a result of this relatively easy and treatable situation.

So in brief summary:

Pellets inserted 10/29/18

Continue T cream for 2 weeks while pellets start to dissolve and get into blood stream.  Stop T-Cream after 2 weeks!

Start DIM – Cannot remember the dosage, I will come back and update

Start Metformin – (10/30/18)  I will have to get dosage

Start walking/exercising regularly (wife has bad knee so running/biking is OUT)

Eliminate sugar.  Sugar fast and detox for 10 days, minimize carbs.  Eat fresh. Diet similar to Whole30 or Paleo/Meditranian diet.
52 year old, 5’-7” and 165 lbs.
exercise:swim 3x/wk & marrial arts 2x/wk

Blood tested 9/19/18

Total = 580 ng/dL (250-827) 59.9%
Free T= 6.87 (4.6- 22.4) 12.8% (10.8 calc)

SHBG= 39 10.0-50.0) 72.5%

Bio-avail= 14.2 (110-575) 8.0%

DHES =not tested %

Estradiol = 22 (<39)

DHES =231 (38-313) =45.5% tested 2/14/18

Currently on 50mcg Synthroid (T4)
TSH = 0.99
Free T4 = 1.30 (0.80 - 1.80)  =50.0% of range
Free T3 = 3.3 (2.3-4.2) = 52.6% of range
Current protocol: 100mg DIM once per day. Reduction back from 200 mg. For 12 weeks. raised total T, freeT remained basically unchanged due to increases SHBG. Estradiol decrease from 30 to 22. Felt no better and maybe worse than at 100mg DIM so going back starting 9/25/18

golfboy307

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Re: My Wifes low T replacement Journey
« Reply #1 on: October 31, 2018, 12:10:53 pm »
FF,

Thanks so much for posting your wife's journey.  I live in St. Louis, and have heard good things about Biobalance.  I actually picked Body Logic (Dr. Brian Warner) over them, but had much the same treatment you have described.

I will try to keep this brief, but my wife has been very happy with her hormone treatment which started about 18 months ago.  She went to Body Logic since I have been using them for my TRT successfully.  She is 50 and in full menopause.  Or rather, she didn't realize it because her OB just kept her on birth control pills and didn't want to deal with her symptoms.  Dr. Warner immediately took her off the Pill, and pulled her hormone levels.  Not unexpected, but both her E and T were barely registering.  She had gained 20 pounds from 125 to 145.  She was pretty miserable.  He started her on E cream, T pellets and progesterone pills.  I call it the HRT trifecta.  She has always worked out a bunch and was so frustrated with the weight gain.  She lost 10 pounds just going off the pill.  Then with some diet tweaks and time for the hormone levels to adjust, she lost the other 10 lbs.  To her credit, she has always maintained a good libido, even with those low hormone levels.  We did actually experience a "honeymoon" period with the first few months. That normalized a bit, but her energy levels and libido remain strong.  Unlike your wife, she does not have any thyroid issues or pre-diabetes.  The only drawbacks have been keeping up with the prescriptions/pellets etc.

So, congrats, and tell your wife to have some patience.  Don't expect too much until the levels get tweaked and optimized.  But it sounds like she is on a good path. 
Age 51, 5'10, 155 lbs
Cholesterol 162 (HDL 59, LDL 87, Trigs 88, LDL-P 850)
Fasting Glucose 65 (down from 97 pre TRT)
A1C:  5.0 (down from 5.7 per TRT)
Homocysteine:  12.4 > 11.0 > 10.2 > 8.9 using B vitamin therapy.  MTHFR positive 

BP  120/78 (using plant based diet and 10 mg Lisinopril ACE Inhibitor)  145/90 prior to meds.

Current protocol:  50 mg Test Cyp IM every 5 days.  No AI.
2/15/17 labs:  Total T (peak day): 1169 (250 - 1100 ng/dl).  Free T 198 pg/ML (46-225).  Sensitive E2: 40 High.  Previously 32. PSA 0.2  Hemocrit 44.2. SHBG: 32
9/15/18 labs:  Total T (trough day):  598 (250 -1100 ng/dl)  Free T 73.9 (46-225) Sensitive E2: 21  Hemocrit 43.7  SHBG 34


Supplements:  Multivitamin, plus additional B12, B6, D, K2, Red Yeast Rice, Magnesium, and Coq10

Evening stack:  2g Citruline, 2.5G Kyolic garlic, 1 LEF Endothelial defense   2 mg Cialis EOD, or as needed, 1000 mg Vitamin C

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Re: My Wifes low T replacement Journey
« Reply #1 on: October 31, 2018, 12:10:53 pm »


Flyingfool

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Re: My Wifes low T replacement Journey
« Reply #2 on: October 31, 2018, 12:42:09 pm »
Thanks for the encouragement and your wife’s experience which is positive.

I think my wife will be fine as long as there is positive evidence of progress. Her probably two big complaints is her inability to sleep well, and her weight. So as long as she shows progress in one or both of those areas she will remain committed.

My lower T levels now may become an issue if I am unable to keep up with her improved sex drive. Assuming that happens for her. My signature block gives my stats.  My latest calculated free T was 10. Ideally probably want not less than about 15. So time will tell if I will need a boost or not.

Wife took the Metformin yeaterday. Caused her significant nausea. So she didn’t take it today and will take half dose and work up more slowly to see if she will tolerate it better.

The pellet insertion point is almost invisible. She is sore but no bruise and no swelling and already seems less sore after inly having them inserted 2 days ago. So I do not understand all the horror stories I have read on the internet about huge scsrs and massive pain etc?  Seems like thise cases were due to lack of proper experience and skill and knowledge to insert them correctly!
52 year old, 5’-7” and 165 lbs.
exercise:swim 3x/wk & marrial arts 2x/wk

Blood tested 9/19/18

Total = 580 ng/dL (250-827) 59.9%
Free T= 6.87 (4.6- 22.4) 12.8% (10.8 calc)

SHBG= 39 10.0-50.0) 72.5%

Bio-avail= 14.2 (110-575) 8.0%

DHES =not tested %

Estradiol = 22 (<39)

DHES =231 (38-313) =45.5% tested 2/14/18

Currently on 50mcg Synthroid (T4)
TSH = 0.99
Free T4 = 1.30 (0.80 - 1.80)  =50.0% of range
Free T3 = 3.3 (2.3-4.2) = 52.6% of range
Current protocol: 100mg DIM once per day. Reduction back from 200 mg. For 12 weeks. raised total T, freeT remained basically unchanged due to increases SHBG. Estradiol decrease from 30 to 22. Felt no better and maybe worse than at 100mg DIM so going back starting 9/25/18

golfboy307

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Re: My Wifes low T replacement Journey
« Reply #3 on: October 31, 2018, 01:37:27 pm »
FF,

Not sure if her HRT has helped with sleep. Probably some, but we are still both pretty light sleepers.  Weight:  as noted above.  Big improvement.  I don't know if this is true in females, but my blood sugar profile has improved DRAMATICALLY since going on TRT.  Prior to treatment, I was nearly pre-diabetic despite being a thin runner who eats well.  Fasting blood sugar was 99 and A1C was 5.7.  Two and half years later those numbers have dropped to 65 and 5.0 respectively.  I am hoping something similar happens for your wife.  Maybe she wont need the Metformin   Pellets:  she has had no issues with insertion other than sore for a couple of days.  (I have to remember not to grab that *ss cheek  ;D  I agree, some of those horror stories seem overblown.  I remain satisfied with my injections.

As for your levels, well, that of course will be up to you.  I was in the upper 300's with free T around 7.  I was pretty miserable.  Treatment has made a big difference for me. 

Please keep us posted..
Age 51, 5'10, 155 lbs
Cholesterol 162 (HDL 59, LDL 87, Trigs 88, LDL-P 850)
Fasting Glucose 65 (down from 97 pre TRT)
A1C:  5.0 (down from 5.7 per TRT)
Homocysteine:  12.4 > 11.0 > 10.2 > 8.9 using B vitamin therapy.  MTHFR positive 

BP  120/78 (using plant based diet and 10 mg Lisinopril ACE Inhibitor)  145/90 prior to meds.

Current protocol:  50 mg Test Cyp IM every 5 days.  No AI.
2/15/17 labs:  Total T (peak day): 1169 (250 - 1100 ng/dl).  Free T 198 pg/ML (46-225).  Sensitive E2: 40 High.  Previously 32. PSA 0.2  Hemocrit 44.2. SHBG: 32
9/15/18 labs:  Total T (trough day):  598 (250 -1100 ng/dl)  Free T 73.9 (46-225) Sensitive E2: 21  Hemocrit 43.7  SHBG 34


Supplements:  Multivitamin, plus additional B12, B6, D, K2, Red Yeast Rice, Magnesium, and Coq10

Evening stack:  2g Citruline, 2.5G Kyolic garlic, 1 LEF Endothelial defense   2 mg Cialis EOD, or as needed, 1000 mg Vitamin C

Peak Testosterone Forum

Re: My Wifes low T replacement Journey
« Reply #3 on: October 31, 2018, 01:37:27 pm »


Redrak

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Re: My Wifes low T replacement Journey
« Reply #4 on: October 31, 2018, 09:24:11 pm »


Some intital data:  Female, age 48 (in January she will be 49), perimenopause. Not physically active and is 5-4 and of 200 lbs.  Total T of 53 (2-45) and serum Free T of 4.3 (0.2-5)

Since there is no real place for women’s issue with Low T, I thought I would create this thread to document my wife’s journey with low T.

A brief history.  She has had a LONG journey with getting her Thyroid treated properly.  MANY years and several Doctors and she is finally pretty much optimized.  But even with this optimized, she still had many symptoms and lack of libido.  We had hoped these would be all remedied by her low thyroid.

When several symptoms remained, I started doing on-line research as to what that may be from.  She had her sex hormones tested as early as mid-July 2014.  And she had unmeasurable level of Testosterone (less than 20).  Several additional tests I think up to 3 over the following years also ALL showed her to have unmeasurable level of T.  Despite my continued pleas for her and her DR to do something about that.  Nothing was done.

When her thyroid was clearly about optimized, and the symptoms remained, we FINALLY convinced the Dr to do something about the T-Levels.  I believe this doctor has treated several men with low T, but I do not think he treated a single female.  So my wife may likely be one of the first, if not THE first.

As a result, he started VERY cautiously. He prescribed a compounded T cream at a very low dosage.  I can’t remember it was something like 0.5 or 1 Mcg per day.

Each successive test resulted in still zero measurable T level. Which corresponded to two or 3 increases in dosage of the T-Cream.

At this time we investigated going to see a true female hormone specialist.  The firm is Biobalance health based in St. Louis and Kansas City.  Watched a TON of healthcast videos, bought the doctors book (The Secret Female Hormone) by Kathy Maupin and Bret Newcomb.  I would HIGHLY recommend both the book and the archive of over 400 half hour video healthcast.  These cover both men and women’s health issues, mostly around hormones, but also other general health issues.

This investigation led to us setting up an appointment for my wife at Biobalance in St. Louis as it is “only” about 350 miles from us.  But she continued to use the T-cream.

I started seeing or noticing my wife losing weight with the T-cream.  In fact I noticed this before my wife did.  And she “wrote it off” as just normal weight fluctuation.  But I kept asking and eventually she did indicate that she was losing.

In prep for her biobalance appointment, the clinic required a significant battery of blood labs and ultrasounds etc.  A detailed health history survey etc.  Very though.

Part of the blood work of course retested for sex hormones.  And her T level FINALLY registered.  Total T was now above the range, but her free T was still only 4.3.  Yet at this point she had lost 14 lbs (she started out and was overweight/obese at over 200 lbs).  Still even with this low amount of T, and little to no change in lifestyle changes, she lost 14 Lbs (about 7% of her body weight)

Biobalance:

Her appointment was just yesterday 10/29/18

The appointment was outstanding.  The doctor took OVER an  hour with BOTH of us.  The Dr talks with and went over and confirmed symptoms and history.  The Doctor went over every blood test result. What was good, what was bad, where it “should” be and how they can help her get to that point.  They provided recommendations and why those recommendations were made, what they would expect to see as a result and how everything would progress.  This not only discussed the Sex hormones, but overall health. Diet, exercise. Changes to supplements, which supplements to stop, which to add, and which to change dosage etc.  Recommended books to read and specific supplements brands that they have had good luck with and having science to back up the quality and consistency, as the unregulated area of supplements means that some are great, and other brands not so much.  So that was great.

The result was that my wife was insulin resistant.  Her being overweight contributed to this as well as other things, Her blood sugar is also on the higher side etc.  This resulted in recommendation of Metformin prescription.  This should help the insulin resistance, along with the changes in diet and exercise program as well as getting Testosterone all should help her lose weight.  The Dr believes that Metformin may only be needed for a fairly short time, as once she loses weight and changes life styles her insulin resistance should reduce.  But this will be monitored.  But the goal is to eliminate this over time in maybe 6 months or so.

Wife also had bad liver enzymes and early indication of liver disease.  They also felt that fatty liver was probably the issue and again the loss of weight and visceral fat may get these back in line over time.

She was given Testosterone pellets along with Airimidex.  Unlike men, controlling estrogen is easier and more straight forward then men. Which is almost always recommended to NOT add an AI until you prove you need it.  Estrogen control is a bit easier in women it would seem.  There is more “margin for error” as women have so much more estrogen.  Also the idea along with DIM was prescribed to help change the estrogen from Estrone (E1), to more estradiol (E2).

The experience is that FREE T is really the only thing they concentrate on.  And the range they use for women to feel well is to have the free Testosterone to be I think 15 to 25.  My wife is only at 4.3,  So they want to at least more than TRIPLE her T level.

My wife has NEVER, EVER had a libido.  And the reports are that usually about 2 weeks after getting pellets, the women will go through a “honeymoon period”.  This is due to the testosterone receptors having been starved of T when suddenly getting testosterone, they women will be EXTREMELY horny. This is a one time event. Not every woman experiences it, but most do. This honeymoon period is pretty short lived lasting only a few days!

I CANNOT WAIT for this time.  IF it happens.  I am a bit dubious that it will happen due to the fact that my wife so slowly built up some Testosterone with the T-Cream that her receptors will have had a chance to adjust and she wo n’t experience this phase.  I pray this is not true.  After 28+ years of marriage to a wife with zero libido I have always hoped and prayed for a wife who would be interested and passionate about sex!  Time will tell. My wife just cannot believe this will happen to her, because in her own words “This is soooo much NOT like “me, that I just can’t see myself being like that.”

My wife is super excited. She cannot wait for “the new her” to come alive. She also cannot imagine herself 40 lbs lighter as she has ALWAYS, ALWAYS struggled with her weight. And no matter how hard she worked or changed diet etc it always resulted in nothing!  So to believe that she has a means to actually have her body work and lose weight given diet and exercise and medicine etc has her extremely excited.  She also is looking forward to better mood, better health and immunity etc. She just cannot imagine herself healthy and happy. Something she also has struggled with her whole life.

I can’t think of anything else at the moment to add. But I wanted to have a place to document her journey. And maybe some of you men out there have a wife that similarly has, or you suspect has a low T problem, but the Doctors won’t do a dang thing about it!  or eve test for testosterone in women!  I hope this will document a success story that other can use to inspire their wives to become their own best advocate and seek treatment.

Ultimately, I would love to have this forum set up a separate folder for female low T issues.  As I think it is extremely important issue that is TOTALLY under diagnosed.  There are a LOT of women, and marriages that are suffering as a result of this relatively easy and treatable situation.

So in brief summary:

Pellets inserted 10/29/18

Continue T cream for 2 weeks while pellets start to dissolve and get into blood stream.  Stop T-Cream after 2 weeks!

Start DIM – Cannot remember the dosage, I will come back and update

Start Metformin – (10/30/18)  I will have to get dosage

Start walking/exercising regularly (wife has bad knee so running/biking is OUT)

Eliminate sugar.  Sugar fast and detox for 10 days, minimize carbs.  Eat fresh. Diet similar to Whole30 or Paleo/Meditranian diet.

but what if my shbg is high? i should not reduce carbs. i do however eat a lot of fruits

Runnerman

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Re: My Wifes low T replacement Journey
« Reply #5 on: October 31, 2018, 10:01:05 pm »


Some intital data:  Female, age 48 (in January she will be 49), perimenopause. Not physically active and is 5-4 and of 200 lbs.  Total T of 53 (2-45) and serum Free T of 4.3 (0.2-5)



So you wife hasn't quite hit menopause? She probably still has her ovaries and uterus with no surgeries at this point? Reason I ask is my wife had a hysterectomy with ovary removal and her libido tanked after that. She also experienced many of the symptoms your wife did with weight gain, high glucose etc. I think she could really benefit from hormone therapy if for no other reason than to help her lose weight and be healthier.
Bio Age - 53, 5'9" 170lbs
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TSH 2.05 on 88mcg synthroid

Dr Justin Saya, MD

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Re: My Wifes low T replacement Journey
« Reply #6 on: November 01, 2018, 07:54:45 am »


Some intital data:  Female, age 48 (in January she will be 49), perimenopause. Not physically active and is 5-4 and of 200 lbs.  Total T of 53 (2-45) and serum Free T of 4.3 (0.2-5)



So you wife hasn't quite hit menopause? She probably still has her ovaries and uterus with no surgeries at this point? Reason I ask is my wife had a hysterectomy with ovary removal and her libido tanked after that. She also experienced many of the symptoms your wife did with weight gain, high glucose etc. I think she could really benefit from hormone therapy if for no other reason than to help her lose weight and be healthier.

Exactly.
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Flyingfool

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Re: My Wifes low T replacement Journey
« Reply #7 on: November 01, 2018, 08:16:11 am »
The entire purpose of this thread was to document her journey of T replacement.

The original post indicated that she WAS and IS on hormone replacement.

She is on thyroid replacement. And initially was on T cream for about 4 months. On 10/29/18 she had testosterone pellets inserted. She will continue to apply the Tcream for 2 weeks.

She has changed her diet and began exercising. She already has lost about 3 lbs.

Also, yes my wife still has uterus and ovaries. Although she has ultrasound verified tumors on uterus and both ovaries. She has follow up ultrasound withinthe next week. Last night she told me she has had occasional sharp but brief pain, in the area of her ovary or perhaps appendix area (lower right side).
52 year old, 5’-7” and 165 lbs.
exercise:swim 3x/wk & marrial arts 2x/wk

Blood tested 9/19/18

Total = 580 ng/dL (250-827) 59.9%
Free T= 6.87 (4.6- 22.4) 12.8% (10.8 calc)

SHBG= 39 10.0-50.0) 72.5%

Bio-avail= 14.2 (110-575) 8.0%

DHES =not tested %

Estradiol = 22 (<39)

DHES =231 (38-313) =45.5% tested 2/14/18

Currently on 50mcg Synthroid (T4)
TSH = 0.99
Free T4 = 1.30 (0.80 - 1.80)  =50.0% of range
Free T3 = 3.3 (2.3-4.2) = 52.6% of range
Current protocol: 100mg DIM once per day. Reduction back from 200 mg. For 12 weeks. raised total T, freeT remained basically unchanged due to increases SHBG. Estradiol decrease from 30 to 22. Felt no better and maybe worse than at 100mg DIM so going back starting 9/25/18

Joe Sixpack

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Re: My Wifes low T replacement Journey
« Reply #8 on: November 01, 2018, 05:29:26 pm »
FF, This is good that you are documenting this.  We don't get to hear much about female HRT. 

FWIW, I thought my wife might have hormone imbalances and finally convinced her to see a hormone clinic locally.  Turns out that she has a nearly perfect hormone profile.  Her thyroid is perfect.  Her only abnormalities are:  her total T levels are almost double the normal and her progesterone is low.  She decided to not treat the high T and low progesterone. 
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

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Re: My Wifes low T replacement Journey
« Reply #9 on: November 02, 2018, 06:50:16 am »
Thank you for sharing this story of your wife's journey and the encouragement you provided.

I can relate to it with my own situation, and hope one day my wife will take a hard look at why she can't lose weight.  For now it's three medications: one for blood sugar control, Metformin, and a Statin for BP.

I wish you both the best in your ongoing journey to wellness.

In the meantime I'm struggling with my less than savvy MD to get my TRT program right.
Shawn (b 3/24/1953)
Chicago, IL
Started with 1-50 mg/ml transdermal cream/day on 4/23/18

shattered dreams

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Re: My Wifes low T replacement Journey
« Reply #10 on: November 02, 2018, 07:44:12 am »
I guess I really do learn something new every day as I have never heard of a woman doing this.  Estrogen yes, but not testosterone.  I have to wonder if any men ever get estrogen replacement. 

Cataceous

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Re: My Wifes low T replacement Journey
« Reply #11 on: November 02, 2018, 08:26:03 am »
Here's an interesting study on testosterone monotherapy in post-menopausal women: Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen

Quote
RESULTS
At 24 weeks, the increase in the 4-week frequency of satisfying sexual episodes was significantly greater in the group receiving 300 μg of testosterone per day than in the placebo group (an increase of 2.1 episodes vs. 0.7, P<0.001) but not in the group receiving 150 μg per day (1.2 episodes, P=0.11). As compared with placebo, both doses of testosterone were associated with significant increases in desire (300 μg per day, P<0.001; 150 μg per day, P=0.04) and decreases in distress (300 μg per day, P<0.001; 150 μg per day, P=0.04). The rate of androgenic adverse events — primarily unwanted hair growth — was higher in the group receiving 300 μg of testosterone per day than in the placebo group (30.0% vs. 23.1%). Breast cancer was diagnosed in four women who received testosterone (as compared with none who received placebo); one of the four received the diagnosis in the first 4 months of the study period, and one, in retrospect, had symptoms before undergoing randomization.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 57, Ht: 5'10", Wt: 158 lbs
Protocol: 18 mg T enanthate subQ qod, 250 IU hCG subQ qod, 70 mcg anastrozole qod, 6.25 mg DHEA orally bid
7-12/2018 test results: TT: 800 ng/dL, E2: 31 pg/mL LC/MS-MS, DHEA-S: 264 ug/dL (49-344)—SHBG ~30 nmol/L

Flyingfool

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Re: My Wifes low T replacement Journey
« Reply #12 on: November 02, 2018, 09:59:12 am »
I ran across a link the other day about 10 myths of T replacement for women.

What most people do not understand is that the highest hormone by volume of a woman is testosterone!  It is as much as 3 to 10 TIMES the volume as estrogen!

Granted the level of a womans T is 1/10th that of a man.

However the fact that testosterone is such a hogh level in a woman compared to estrogen should twll you two things!

1) how extremely important testosterone is for a woman
And
2) how extremely powerful estrogen is! 

Almost  every single issue and thing we commonly recognize as “old lady” is the result of the loss of testosterone. Principally osteoporosis and frailty, resulting in falls and broken hips and high mortality associated with pelvis breaks. Flabby tricepts, muscle loss, belly fat.

Osteoporosis is principally a female problem since they have so mich less Testosterone, so when they lose what mittle they have (compared to men) they immediately start losing the ability to build bone.

There are plenty of studies that prove women who are pre-osteo or even in full nlown osteo, once rhey get proper levels of testosterone and hormones rhey build bone. Some after a couple of years have so reversed the situation and built enough bone that they no longer are classified as having, or being at risk for osteo.

Again read the book “The secret Female Hormone” by Dr Kathy Maupin and Brett Newcomb.

All cause mortality is also reduced by women (and men) on hormone replacement. Life expectancy may not be significantly longer, yet the people who receive hormone replacement, have a MUCH healthier quality of mife, are able to love longer independently etc. in large lart due to muscle tone and strength allowing them to be able bodied for much later in life without needing walkers and canes etc. 
52 year old, 5’-7” and 165 lbs.
exercise:swim 3x/wk & marrial arts 2x/wk

Blood tested 9/19/18

Total = 580 ng/dL (250-827) 59.9%
Free T= 6.87 (4.6- 22.4) 12.8% (10.8 calc)

SHBG= 39 10.0-50.0) 72.5%

Bio-avail= 14.2 (110-575) 8.0%

DHES =not tested %

Estradiol = 22 (<39)

DHES =231 (38-313) =45.5% tested 2/14/18

Currently on 50mcg Synthroid (T4)
TSH = 0.99
Free T4 = 1.30 (0.80 - 1.80)  =50.0% of range
Free T3 = 3.3 (2.3-4.2) = 52.6% of range
Current protocol: 100mg DIM once per day. Reduction back from 200 mg. For 12 weeks. raised total T, freeT remained basically unchanged due to increases SHBG. Estradiol decrease from 30 to 22. Felt no better and maybe worse than at 100mg DIM so going back starting 9/25/18

Joe Sixpack

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Re: My Wifes low T replacement Journey
« Reply #13 on: November 02, 2018, 07:15:17 pm »
  I have to wonder if any men ever get estrogen replacement.
Men who are estrogen deficient are usually that way because they are testosterone deficient.  In men E2 is created from T.   So most doctors treat the low T which in turn treats the low E2.  Usually if you get the T high enough it also fixes the low E2.  Doctors typically do not directly prescribe E2 to men. 
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

Flyingfool

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Re: My Wifes low T replacement Journey
« Reply #14 on: November 03, 2018, 08:31:22 am »
Here is a link that debunks the 10 myths of testosterone in women:

https://www.sciencedirect.com/science/article/pii/S0378512213000121

Here is a brief article on pellets for women:

https://www.power2practice.com/article/pellet-implant-testosterone-for-women-the-medical-studies/

Pellets seem for women to he the best way to administer testosterone if not Estradiol as well. Women, especially post menopausal women have a steady or more constant level of hormone. Men may seem to need the daily, or at least weekly fluctuation as men typically naturally have a diurnal fluctuation of T. Usually pushed out in early morning.

Also pellets allow for the most direct way to get into bloodstream. Minimizing DHT which is mostly not a good thing for women, where men seems loke some DHT is needed especially for libido.

It seems to me a good protocol for a man may be to have pellets for a base T level that is steady and limits the troughand then daily or 2 or 3 times a week to add a gel or cream maybe to scrotum to replicate or mimick the diurnal pulse of T, give small amount of DHT for good libido. At least it makes sense in theory to me anyhow.
52 year old, 5’-7” and 165 lbs.
exercise:swim 3x/wk & marrial arts 2x/wk

Blood tested 9/19/18

Total = 580 ng/dL (250-827) 59.9%
Free T= 6.87 (4.6- 22.4) 12.8% (10.8 calc)

SHBG= 39 10.0-50.0) 72.5%

Bio-avail= 14.2 (110-575) 8.0%

DHES =not tested %

Estradiol = 22 (<39)

DHES =231 (38-313) =45.5% tested 2/14/18

Currently on 50mcg Synthroid (T4)
TSH = 0.99
Free T4 = 1.30 (0.80 - 1.80)  =50.0% of range
Free T3 = 3.3 (2.3-4.2) = 52.6% of range
Current protocol: 100mg DIM once per day. Reduction back from 200 mg. For 12 weeks. raised total T, freeT remained basically unchanged due to increases SHBG. Estradiol decrease from 30 to 22. Felt no better and maybe worse than at 100mg DIM so going back starting 9/25/18

Peak Testosterone Forum

Re: My Wifes low T replacement Journey
« Reply #14 on: November 03, 2018, 08:31:22 am »