Dropping SHBG from 28 nmol/L to 17 doesn't affect calculated free T as much as I thought it would. Free T goes from 17 ng/dL up to 21. One possible implication is that this level of SHBG is still borderline, and not severely low. It would be interesting to know the change in free estradiol. Free estradiol is generally assumed to be the culprit when low SHBG is associated with problems. Unfortunately the doctors commenting here have not gone into detail about their results in treating these "challenging" cases.
The margin of error for the algorithmic predictions are massive as SHBG approaches out of range low values. I made a detailed post about this. By calculation, you'll still have normal range FT with even zero (0.01) nmol/L SHBG. This is incorrect, and we have a real world no-SHBG male in the literature to prove it.
(Quoting you bc I know you have done a lot of research on SHBG over the years but the following is for anybody)
In case my SHBG change is leading to the sexual issues via high free E2, I need to get my SHBG back up.
I know this is not a TRT induced SHBG decrease bc over the years I have had SHBG in the mid 20s even on TRT. So its likely due to something else.
I know James you say (in other postsójust from my memory over the years) its not possible to increase SHBG with just lifestyle. But should it be possible for soemone like me who had previously normal SHBG to get back to that with lifestyle changes? Such as cutring out sugar again. I used to cut out sugar but this year was like whatever about it and have too much now.
I think my SHBG decrease is msot likely some lifestyle factor. Maybe I should also test A1C/insulin/glucose all fastint too? Havent done those in a long time but I have previous numbers.