Interestingly, I have found that when I administer a propionate shot in the morning - my circadian rhythm is superb. No alarm clock needed. At least per a 3 week trial vs. PM where 4 hours after the shot, I begin to feel restless (even though in theory - this is a small level above my trough level).
I'm still trialling this PM experiment inspired by the theory that peak levels ought to be reached shortly after waking (I detest the trough in the morning unless im on a much higher dose/shot), however, so far, I am struggling a little (due to the later hour I find myself sleeping). It could be interesting if it were true that diurnal variation links in to a number of other/pervasive bodily systems e.g.
How confident are you about when your peak is? I've been wondering how we can model our personal pharmacokinetics for the various esters. It doesn't seem to be easy. One approach is to use existing research. With subQ there's already a disadvantage, because there's much less on it. And even the IM studies don't have large enough Ns to include variables like SHBG. Another approach is to take multiple blood tests yourself. But aside from not being fun, you have think hard about your experiment. How do you account for existing hormone levels if you don't want to go through a prolonged and unpleasant washout period?
I suppose that's why in the end it's easier to just try different protocols, consider the subjective results, and get the occasional snapshot of hormone levels via testing.
Related to all this, I'm wondering just what kind of diurnal variation there is with daily propionate? Some simple models based on IM say about 25%. With subQ I'd expect more like 15-20%. This isn't the youthful variation of 30-50%. How to simulate this? Perhaps a daily injection consisting of a smaller base level of a long-lived ester such as T cypionate, in combination with ester-less testosterone. Ideally the injection would be in the very early AM, but maybe upon awakening would be viable. There are still a couple potential problems: The pharmacokinetics of ester-less testosterone, aka TNE, are not well-studied, so it's not clear if the half life would work for this. Also, TNE might have the potential to aromatize directly when injected subcutaneously. It's hard to know in advance if estradiol would be a problem.
- did we originally hunt more in the early AM/day than afternoon/PM (I'm making a case for higher T levels in the morning)?
- Are lower T levels (but perhaps better T/E ratio) linked to optimal sexual function?
- Does the body measure the 'rate of change' as a means to deduce which activity it is preparing for i.e. rising levels + certain ratio = peak strength and alertness, decreasing levels + certain ratio = enhanced sexual function / preparing for sleep / increased melatonin?
These are interesting and plausible hypotheses. I especially think there's something to the "rate of change" idea. There's a stack of anecdotal evidence suggesting something like this is going on.