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Author Topic: Live long die young. NAD and mitochondria  (Read 507 times)

HRD LVN

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Live long die young. NAD and mitochondria
« on: January 20, 2019, 10:14:44 pm »
In my never ending study for why T is not the complete answer I stumbled on this video on what science is doing along the lines of anti aging.

This video came out Jun 21, 2016 I can't seem to find out much more on NAD and mitochondria. Seems like these little power packs filled with NAD are why 20 year olds can stay up all night. Require little sleep and recover so quickly from exersize and why 50 year olds with TRT optimized can't.

I would like everyone thought on this matter. Not looking for a big fight or debate looking at you guru. Just a friendly discussion on the topic.

Have you guys heard of NAD?
I wonder if Testosterone levels play any role in how many of these NAD's we have stored? Listening to this video it seem the fountain of youth is not TRT but NAD. Your thoughts.
I've cued up the video at 7:13 that is where they are talking abut the NAD. Actually the whole 30 minutes is pretty interesting for guys like us trying to improve our aging.
https://youtu.be/5Whz431eJVI?t=432

« Last Edit: January 20, 2019, 10:18:45 pm by HRD LVN »


Peak Testosterone Forum

Re: Live long die young. NAD and mitochondria
« Reply #1 on: January 21, 2019, 10:04:53 am »


HRD LVN

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Re: Live long die young. NAD and mitochondria
« Reply #2 on: January 21, 2019, 01:00:26 pm »
Peak had posted some articles about it

https://www.peaktestosterone.com/forum/index.php?topic=7946.0

https://www.peaktestosterone.com/forum/index.php?topic=5433.0

https://www.peaktestosterone.com/forum/index.php?topic=5624.0

Thanks Osprey, It looks like PeakT our old admin, rest his sole,  tried on 3 seperate occasions to get the NAD discussion going with little interest from the forum members. Oh well it was a shot in the dark. I had hoped I had found my next journey deeper into improving my health by adding this NAD to my TRT.

jacob2001

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Re: Live long die young. NAD and mitochondria
« Reply #3 on: January 21, 2019, 06:52:09 pm »
its a subject that has recently piqued my interest from a number of angles. i have ordered nicotinamide riboside (nad precursor), niacinamide, p5p, pqq and ubiquinol. i hope a combination will speed up cell recovery and energy availability as well as assisting as coenzymes in the formation of dopamine and serotonin thus providing a mood boost.

the trouble is the universe of supplements is huge and my main challenge is to gain a better understanding of which are actually helping and how they work with one another. the idea should be to take the minimum to get the maximum benefit but thats easier said than done.



Peak Testosterone Forum

Re: Live long die young. NAD and mitochondria
« Reply #3 on: January 21, 2019, 06:52:09 pm »


ghce

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Re: Live long die young. NAD and mitochondria
« Reply #4 on: January 21, 2019, 08:45:33 pm »
its a subject that has recently piqued my interest from a number of angles. i have ordered nicotinamide riboside (nad precursor), niacinamide, p5p, pqq and ubiquinol. i hope a combination will speed up cell recovery and energy availability as well as assisting as coenzymes in the formation of dopamine and serotonin thus providing a mood boost.

the trouble is the universe of supplements is huge and my main challenge is to gain a better understanding of which are actually helping and how they work with one another. the idea should be to take the minimum to get the maximum benefit but thats easier said than done.




Ditto, done the same. but they have all been sitting unused ( 2 years more) until I have done more research
Age:57, Height 6' 3" weight 92.5KG
2014 Androderm Patches
2014-2016 Andriol 160mg
June 2016 Clomid/Serophene 12.5mg EOD
September 2016 no TRT all natural and supplements for the time being
February 2017 Testosterone cream 100mg daily

Sept 2016
Testosterone   8.2 nmol/l   9-38
Free Testosterone   239 pmol/l   L   250-800
SHBG:  14    nmol/L   9-60
Free Androgen index   586   >400
Oestradiol    112   pmol/L    <190
LH    2.6 IU/L Adult male   2 - 9 IU/L
FSH  1.4 IU/L Adult male L2 - 12 IU/L

22 November
T 6.8  nmol/L ( 9-38 ) L

March 2017
Testosterone:   45.0  nmol/L ( 9-38 ) H ( 1,323 ng/dl )
Free Testosterone:   1512  pmol/L ( 250-800 ) H
SHBG:   17  nmol/L ( 9-60 )
Plasma IGF-1:   227 ug/L ( 55-198 ) H
Plasma cortisol:   434 nmol/L ( 0600-1000 hrs 170-500 nmol/L )
HbA1c:   36 mmol/mol ( 20-40 )
LH:   <0.1 IU/L
FSH:   0.1 IU/L
DHT Plasma Dihydrotestosterone:   7455   pmol/L ( 223 ng/dl ) 

Reference Range Adult males  1000-6000 pmol/L

cujet

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Re: Live long die young. NAD and mitochondria
« Reply #5 on: January 27, 2019, 05:57:44 am »
I've been diagnosed with mitochondrial dysfunction (by my prev endo) (switched to Clev Clin, huge battery of tests, without any additional help or suggestions)

I suffer from slowly worsening exercise intolerance and crushing fatigue.

As you may have guessed, I've tried all the various mito "fuels" I can find. Nadh, B3, (all of the B's individually) CoQ10 and https://wiki.med.umich.edu/display/NEURO/Mitochondrial+Vitamin+Cocktail

The only thing that helps is a drink made with amino energy, creatine and D-Ribose. No surprise really, as that seems to be a roundabout way to fuel mitochondria.

55 years old
Autoimmune Hashimoto's, near zero natural T production
Cause: severe mononucleosis in my early 30's
Weight 200
Height 5' 10"
190mg NPthyroid (natural dessicated pigs thyroid)
Labs (Oct 2017) , my T=730, TSH 0.03, T3+T4 mid-range normal.
 
Currently not using T of any sort due to low cortisol

Joe Sixpack

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Re: Live long die young. NAD and mitochondria
« Reply #6 on: January 27, 2019, 07:25:40 pm »
Mitochondria and fasting always seem to come up together.  IIRC one of the benefits of fasting is that it activates autophagy, your bodies own cleansing process.  Autophagy in turn cleans up damaged mitochondria so that your body will generate fresh new ones.  Fasting as well as intermittent fasting is becoming a hot topic.  It seems like every other day I am reading about some new study showing a new dimension on how fasting is beneficial. 

I tried a two day fast a while back.  The first day sucked and was hard to get thru.  But day 2, I felt great. 
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

cujet

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Re: Live long die young. NAD and mitochondria
« Reply #7 on: January 28, 2019, 08:25:22 pm »
Mitochondria and fasting always seem to come up together.  IIRC one of the benefits of fasting is that it activates autophagy, your bodies own cleansing process.  Autophagy in turn cleans up damaged mitochondria so that your body will generate fresh new ones.   

I have also done the fasting thing with good results. I had no idea it was beneficial for mito.

Any idea on what would be an ideal fast for mito improvement?
55 years old
Autoimmune Hashimoto's, near zero natural T production
Cause: severe mononucleosis in my early 30's
Weight 200
Height 5' 10"
190mg NPthyroid (natural dessicated pigs thyroid)
Labs (Oct 2017) , my T=730, TSH 0.03, T3+T4 mid-range normal.
 
Currently not using T of any sort due to low cortisol

Joe Sixpack

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Re: Live long die young. NAD and mitochondria
« Reply #8 on: January 29, 2019, 08:41:27 pm »
Mitochondria and fasting always seem to come up together.  IIRC one of the benefits of fasting is that it activates autophagy, your bodies own cleansing process.  Autophagy in turn cleans up damaged mitochondria so that your body will generate fresh new ones.   

I have also done the fasting thing with good results. I had no idea it was beneficial for mito.

Any idea on what would be an ideal fast for mito improvement?
IDK what the ideal would be.  And I am far from an expert, but from what I understand the longer the better, provided you are taking precautions, like getting enough electrolytes and water.  I do know that you have to fast at least 12-14 hours before any of the good stuff happens.  So that's the minimum. 
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

HRD LVN

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Re: Live long die young. NAD and mitochondria
« Reply #9 on: January 30, 2019, 11:32:48 am »

IDK what the ideal would be.  And I am far from an expert, but from what I understand the longer the better, provided you are taking precautions, like getting enough electrolytes and water.  I do know that you have to fast at least 12-14 hours before any of the good stuff happens.  So that's the minimum.
I'm retired I can easly sleep for 12 hours does that count? HaHa see honey sleeping in is good for me.

Joe Sixpack

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Re: Live long die young. NAD and mitochondria
« Reply #10 on: January 30, 2019, 04:28:02 pm »

IDK what the ideal would be.  And I am far from an expert, but from what I understand the longer the better, provided you are taking precautions, like getting enough electrolytes and water.  I do know that you have to fast at least 12-14 hours before any of the good stuff happens.  So that's the minimum.
I'm retired I can easly sleep for 12 hours does that count? HaHa see honey sleeping in is good for me.
Hey that works for me!
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

cujet

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Re: Live long die young. NAD and mitochondria
« Reply #11 on: January 30, 2019, 04:29:19 pm »
Heck, lately I'm sleeping 12 hours whether I like it or not.
55 years old
Autoimmune Hashimoto's, near zero natural T production
Cause: severe mononucleosis in my early 30's
Weight 200
Height 5' 10"
190mg NPthyroid (natural dessicated pigs thyroid)
Labs (Oct 2017) , my T=730, TSH 0.03, T3+T4 mid-range normal.
 
Currently not using T of any sort due to low cortisol

ADHDandOCD

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Re: Live long die young. NAD and mitochondria
« Reply #12 on: January 30, 2019, 11:33:53 pm »
In my never ending study for why T is not the complete answer I stumbled on this video on what science is doing along the lines of anti aging.

This video came out Jun 21, 2016 I can't seem to find out much more on NAD and mitochondria. Seems like these little power packs filled with NAD are why 20 year olds can stay up all night. Require little sleep and recover so quickly from exersize and why 50 year olds with TRT optimized can't.

I would like everyone thought on this matter. Not looking for a big fight or debate looking at you guru. Just a friendly discussion on the topic.

Have you guys heard of NAD?
I wonder if Testosterone levels play any role in how many of these NAD's we have stored? Listening to this video it seem the fountain of youth is not TRT but NAD. Your thoughts.
I've cued up the video at 7:13 that is where they are talking abut the NAD. Actually the whole 30 minutes is pretty interesting for guys like us trying to improve our aging.
https://youtu.be/5Whz431eJVI?t=432

Yeah electron transports and FADH2 and all that.  Those are just what support ATP being synthesized with tRNA and yet when I was taught all that I was nearly asleep in biology class thinking about how much I hate my life's circumstances lol. 

Even knowing what I'm doing to my body with testosterone and hormones and even having optimized hormones helps yeah, but I honestly just am so anhedonic most days of my life I could be getting married tomorrow and I'd probably be 50% as happy as most guys would be just simply from the fact that I struggle to experience pleasure very well. 

Flyingfool

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Re: Live long die young. NAD and mitochondria
« Reply #13 on: January 31, 2019, 11:16:59 am »
Just a crazy theory.

But with all the variois meds and stimulants you take, could it be that your pleasure receptors are burnt out or sensitize to a high level of stimulation. So that just like andrug addict needs more and more drug to get the same “high”,

Could you have conditioned your body to “need” extremely high levels of stimulation, thus it becomes ever more difficult for you to perceive pleasure?

Like I said just a crazy thought I had.
52 year old, 5’-7” and 165 lbs.
exercise:swim 3x/wk & marrial arts 2x/wk

Blood tested 9/19/18

Total = 580 ng/dL (250-827) 59.9%
Free T= 6.87 (4.6- 22.4) 12.8% (10.8 calc)

SHBG= 39 10.0-50.0) 72.5%

Bio-avail= 14.2 (110-575) 8.0%

DHES =not tested %

Estradiol = 22 (<39)

DHES =231 (38-313) =45.5% tested 2/14/18

Currently on 50mcg Synthroid (T4)
TSH = 0.99
Free T4 = 1.30 (0.80 - 1.80)  =50.0% of range
Free T3 = 3.3 (2.3-4.2) = 52.6% of range
Current protocol: 100mg DIM once per day. Reduction back from 200 mg. For 12 weeks. raised total T, freeT remained basically unchanged due to increases SHBG. Estradiol decrease from 30 to 22. Felt no better and maybe worse than at 100mg DIM so going back starting 9/25/18

Peak Testosterone Forum

Re: Live long die young. NAD and mitochondria
« Reply #13 on: January 31, 2019, 11:16:59 am »