.25mg altogether, or at each injection?
I will amend my suggestion above to add .25mg/wk of your anastrozole do to your weight and E2 being already over range before TRT.
My SHBG is 41 nmole/liter (16.5-55.9)
My estradiol is 41 of/mL (8-35)
.25mg/wk not at every injection. In 5-6 weeks your T will be at a steady state and your E2 with AI should be stable at some number. Get a mini blood test TT/FT/E2 then we can go from there. If your doc won't give you the mini blood test buy it from DiscountedLabs that is where I go. It is dirt cheap and they are a sponsor here. In fact Nelson sent me an email back on 3/14 Save 10 Percent Off Our Everyday Low Prices by Using this Code at Checkout:
At your current body fat percent you are going to make a lot of E2 from your injections. This is another reason I suggest you start much lower than 200/wk. 80 is much safer with less bad sides but enough to get your metabolism fired up so you can start burning that fat.
I am 5'9" I was 260 (42"waist) 3 years ago I am 192 now 34" waist). Been there done that so to speak.
No one want to crash their E2 the bad side effects really suck but you also don't want your E2 to go any higher in fact IMO your >40 is way to high.
24-33 would be a much better range. Being so over weight you could already have the beginnings of gyno. Having over ranged E2 and over ranged prolactin is how boys start the process of becoming girls.