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Author Topic: Why is lack of libido so prominent on TRT?  (Read 276 times)

sh1209

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Why is lack of libido so prominent on TRT?
« on: July 14, 2019, 04:24:35 am »
Iíve never understood why so many men struggle with a lack of or no libido on trt. This has been one of my biggest problems from the start nearly ten years ago. Thereís nothing I havenít tried. Something changes once testosterone is replaced that we donít understand. It seems more and more men are jumping ship with trt for various reasons. Even these forums donít have near the traffic they once had. TRT has a long way to go to be really successful in the majority of men. Iím doing test only at a small weekly dose and this is the only thing that works for me as far as since of well-being. Hopefully in the near future some of these bright doctors will come up with better ways to treat hypogonadism. The human body is such a complex design and as we see tinkering with hormones can have some really bad effects on some people. Whoever does perfect this in the future will certainly become a wealthy individual.

ghce

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Re: Why is lack of libido so prominent on TRT?
« Reply #1 on: July 14, 2019, 04:57:29 am »
Testosterone is not the only thing that controls libido thats for sure. DHT is a very neglected part of most protocols along with the many other chemicals that the brain needs.

I may be completely wrong but most T protocols do not increase DHT as they are not applied near the testicles which is the site that actually makes DHT.
Age:57, Height 6' 3" weight 92.5KG
2014 Androderm Patches
2014-2016 Oral Andriol 160mg Daily
June 2016 Clomid/Serophene 12.5mg EOD
September 2016 no TRT all natural and supplements for the time being
February 2017 Testosterone cream 100mg daily

Sept 2016
Testosterone   8.2 nmol/l   9-38
Free Testosterone   239 pmol/l   L   250-800
SHBG:  14    nmol/L   9-60
Free Androgen index   586   >400
Oestradiol    112   pmol/L    <190
LH    2.6 IU/L Adult male   2 - 9 IU/L
FSH  1.4 IU/L Adult male L2 - 12 IU/L

22 November
T 6.8  nmol/L ( 9-38 ) L

March 2017
Testosterone:   45.0  nmol/L ( 9-38 ) H ( 1,323 ng/dl )
Free Testosterone:   1512  pmol/L ( 250-800 ) H
SHBG:   17  nmol/L ( 9-60 )
Plasma IGF-1:   227 ug/L ( 55-198 ) H
Plasma cortisol:   434 nmol/L ( 0600-1000 hrs 170-500 nmol/L )
HbA1c:   36 mmol/mol ( 20-40 )
LH:   <0.1 IU/L
FSH:   0.1 IU/L
DHT Plasma Dihydrotestosterone:   7455   pmol/L ( 223 ng/dl ) 
Reference Range Adult males  1000-6000 pmol/L

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Re: Why is lack of libido so prominent on TRT?
« Reply #1 on: July 14, 2019, 04:57:29 am »


Cataceous

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Re: Why is lack of libido so prominent on TRT?
« Reply #2 on: July 14, 2019, 05:17:22 am »
In addition to raising DHT as ghce suggests, have you tried all of the following?

ē Test serum progesterone and supplement if low.

ē Use a protocol that gives a significant diurnal variation in serum testosterone, such as a 50% drop from peak to trough. This is not necessarily easy, as transdermal testosterone won't create large swings for everyone, and excess DHT is a problem for some. A combination of a testosterone ester and pure testosterone may be injected daily, but it's not something everyone could stay with.

ē Experiment with PT-141.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 57, Ht: 5'10", Wt: 158 lbs
Protocol: 18 mg T enanthate subQ qod, 250 IU hCG subQ qod, 70 mcg anastrozole qod, 6.25 mg DHEA orally bid
7-12/2018 test results: TT: 800 ng/dL, E2: 31 pg/mL LC/MS-MS, DHEA-S: 264 ug/dL (49-344)óSHBG ~30 nmol/L

sh1209

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Re: Why is lack of libido so prominent on TRT?
« Reply #3 on: July 14, 2019, 05:39:00 am »
Progesterone has been low since starting trt but Iíve only tried pregnenolone which made me super tired even with 5mg per day. Same with dhea, never had any subjective benefit other than raising a lab value.  Iíve had DHT to the top of the range a few times and really didnít seem to notice a difference. I did have better libido on androgel 1.62 but have more energy on injections. Itís just weird that some guys with t levels in the 200-300ng range still have healthy libidos. Itís a complex issue to pin down for sure.

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Re: Why is lack of libido so prominent on TRT?
« Reply #3 on: July 14, 2019, 05:39:00 am »


HRT Guru

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Re: Why is lack of libido so prominent on TRT?
« Reply #4 on: July 14, 2019, 12:55:57 pm »
Sometimes going against the grain is the way to go, for instance keeping my E in the single digits has resolved many negative things for me, irrespective of FT/TT values but I have very low SHBG, too.

Libido is multi-faceted and get's painted with a broad brush as far as interest in sex, and the ability to have sex...two different things.

sh1209

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Re: Why is lack of libido so prominent on TRT?
« Reply #5 on: July 14, 2019, 07:11:43 pm »
For me itís the lack of desire to have sex or the urge. Functionality is fine, just hardly ever think about it. Seems trt does this to a good number of men. Hormones are just so multi faceted and unfortunately the body usually adapts to changes which is why we all have the honeymoon period.

Festus

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Re: Why is lack of libido so prominent on TRT?
« Reply #6 on: July 15, 2019, 08:59:59 pm »
Adding to Cataceous's points, I would try a  low dose of Chasteberry to lower prolactin. It has a very noticeable benefit for me and, like DHT, I think prolactin is under-appreciated. If you try the PT-141, I would go with a much lower dose than is commonly discussed. Try 100-200 mcg per-day and slowly titrate up to no more than 500mcg.

Joe Sixpack

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Re: Why is lack of libido so prominent on TRT?
« Reply #7 on: July 16, 2019, 08:53:55 pm »
Iíve never understood why so many men struggle with a lack of or no libido on trt. This has been one of my biggest problems from the start nearly ten years ago. Thereís nothing I havenít tried. Something changes once testosterone is replaced that we donít understand. It seems more and more men are jumping ship with trt for various reasons. Even these forums donít have near the traffic they once had. TRT has a long way to go to be really successful in the majority of men. Iím doing test only at a small weekly dose and this is the only thing that works for me as far as since of well-being. Hopefully in the near future some of these bright doctors will come up with better ways to treat hypogonadism. The human body is such a complex design and as we see tinkering with hormones can have some really bad effects on some people. Whoever does perfect this in the future will certainly become a wealthy individual.
Did you try testosterone cream applied to the scrotum?  My libido added another gear after I started using the cream.
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

sh1209

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Re: Why is lack of libido so prominent on TRT?
« Reply #8 on: July 17, 2019, 04:54:42 am »
I tried some log androgel I have at home but it didnít really seem to make a difference. Perhaps I should try it for a couple weeks to see how it does.

Forty2

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Re: Why is lack of libido so prominent on TRT?
« Reply #9 on: July 17, 2019, 02:19:43 pm »
Iíve never understood why so many men struggle with a lack of or no libido on trt. This has been one of my biggest problems from the start nearly ten years ago. Thereís nothing I havenít tried. Something changes once testosterone is replaced that we donít understand. It seems more and more men are jumping ship with trt for various reasons. Even these forums donít have near the traffic they once had. TRT has a long way to go to be really successful in the majority of men. Iím doing test only at a small weekly dose and this is the only thing that works for me as far as since of well-being. Hopefully in the near future some of these bright doctors will come up with better ways to treat hypogonadism. The human body is such a complex design and as we see tinkering with hormones can have some really bad effects on some people. Whoever does perfect this in the future will certainly become a wealthy individual.
Did you try testosterone cream applied to the scrotum?  My libido added another gear after I started using the cream.

How much cream are you applying to the scrotum, Joe? What concentration is the cream and are you applying the cream to any other part of the body?

Joe Sixpack

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Re: Why is lack of libido so prominent on TRT?
« Reply #10 on: July 19, 2019, 07:38:42 pm »
Iíve never understood why so many men struggle with a lack of or no libido on trt. This has been one of my biggest problems from the start nearly ten years ago. Thereís nothing I havenít tried. Something changes once testosterone is replaced that we donít understand. It seems more and more men are jumping ship with trt for various reasons. Even these forums donít have near the traffic they once had. TRT has a long way to go to be really successful in the majority of men. Iím doing test only at a small weekly dose and this is the only thing that works for me as far as since of well-being. Hopefully in the near future some of these bright doctors will come up with better ways to treat hypogonadism. The human body is such a complex design and as we see tinkering with hormones can have some really bad effects on some people. Whoever does perfect this in the future will certainly become a wealthy individual.
Did you try testosterone cream applied to the scrotum?  My libido added another gear after I started using the cream.

How much cream are you applying to the scrotum, Joe? What concentration is the cream and are you applying the cream to any other part of the body?
I use 1 click to the scrotum and another click to my forearms.  The concentration is 200 mg/gr.  IIRC this equals 50mg per click. 
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

Joe Sixpack

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Re: Why is lack of libido so prominent on TRT?
« Reply #11 on: July 19, 2019, 07:40:49 pm »
I tried some log androgel I have at home but it didnít really seem to make a difference. Perhaps I should try it for a couple weeks to see how it does.
From what I understand, androgel is a weak product compared to compounded creams.  You may not get much out of andro.  I've also heard that the gel can be irritating on the scrotum.  Granted, the cream itches a little.  But it is a minor annoyance.
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

ghce

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Re: Why is lack of libido so prominent on TRT?
« Reply #12 on: July 19, 2019, 11:38:00 pm »
I tried some log androgel I have at home but it didnít really seem to make a difference. Perhaps I should try it for a couple weeks to see how it does.
From what I understand, androgel is a weak product compared to compounded creams.  You may not get much out of andro.  I've also heard that the gel can be irritating on the scrotum.  Granted, the cream itches a little.  But it is a minor annoyance.

Thats my understanding also, the gels are not a good thing on sensitive skin, compounded cremes are the way to go ( probably a lot cheaper too!)
Age:57, Height 6' 3" weight 92.5KG
2014 Androderm Patches
2014-2016 Oral Andriol 160mg Daily
June 2016 Clomid/Serophene 12.5mg EOD
September 2016 no TRT all natural and supplements for the time being
February 2017 Testosterone cream 100mg daily

Sept 2016
Testosterone   8.2 nmol/l   9-38
Free Testosterone   239 pmol/l   L   250-800
SHBG:  14    nmol/L   9-60
Free Androgen index   586   >400
Oestradiol    112   pmol/L    <190
LH    2.6 IU/L Adult male   2 - 9 IU/L
FSH  1.4 IU/L Adult male L2 - 12 IU/L

22 November
T 6.8  nmol/L ( 9-38 ) L

March 2017
Testosterone:   45.0  nmol/L ( 9-38 ) H ( 1,323 ng/dl )
Free Testosterone:   1512  pmol/L ( 250-800 ) H
SHBG:   17  nmol/L ( 9-60 )
Plasma IGF-1:   227 ug/L ( 55-198 ) H
Plasma cortisol:   434 nmol/L ( 0600-1000 hrs 170-500 nmol/L )
HbA1c:   36 mmol/mol ( 20-40 )
LH:   <0.1 IU/L
FSH:   0.1 IU/L
DHT Plasma Dihydrotestosterone:   7455   pmol/L ( 223 ng/dl ) 
Reference Range Adult males  1000-6000 pmol/L

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Re: Why is lack of libido so prominent on TRT?
« Reply #12 on: July 19, 2019, 11:38:00 pm »