Adding in Free Estradiol alongside LC/MS/MS, IMHO, is crucial for the low SHBG guy, another layer of insight.
Since sensitivity was mentioned I see improvements when my LC/MS/MS is in the single digits and my Free E is about mid range.
Target having your E2 mirror your SHBG value if not a little under in trough. Remember we know that SHBG binds T and E the same, high Free T is likely to in turn = high Free Estrogen. When I started to abide by E2 and SHBG value mirroring one another is when things got a lot better for me.