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Author Topic: L-Arginine High Dose for E.D.  (Read 3078 times)

StephCurryFtw

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L-Arginine High Dose for E.D.
« on: July 29, 2019, 06:23:53 am »
Hey.  I have been wondering if there is some research somewhere about the safety of L-Arginine (either tabs or caps) that would be for people dealing with E.D. taking an L-Arginine supplement at high doses.  My current bottle says no more than 2000 mg/day, but I have been carefully increasing that to see if it helps my E.D. 

Now, I do have a pretty low-functioning pituitary gland, so I hate to be biased, but I have had some decent results with up to 6000-8000 mg of L-Arginine.  That is 3-4 times the maximum dose my current L-Arginine capsules supplement advises, but I am also embarrassed to go to a regular doctor and ask them about erectile dysfunction even though I am 23...  I can get an erection, but it is just difficult to maintain it before going flaccid again. 

« Last Edit: July 29, 2019, 06:30:25 am by StephCurryFtw »
December 17th, 2020:

TT: 543.85 ng/dL (245-970 ng/dL)
FT: 11.82 pg/mL (47-293 pg/mL)
Prolactin: 25.76 ng/mL (3-13 ng/mL)
SHBG: 8.69 nmol/L (10-40 nmol/L)
E2: 25.26 pg/mL (10-40 pg/mL)
DHEA-S: 629.71 mg/dL (280-640 mg/dL)
Cortisol @ 8 A.M.: 23.64 mcg/dL (10-20 mcg/dL)
TSH: 2.38 mIU/L (0.5-4.15 mIU/L)
T3: 137.63 ng/dL (100-200 ng/dL)
T4: 1.39 ng/dL (0.8-1.8 ng/dL)
(Reverse) T3: 15.37 ng/dL (9.2-24.1 ng/dL)
FSH: 4.36 mIU/mL (1.5-12.4 mIU/mL)
LH: 3.66 IU/L (1.24-7.8 IU/L)

ghce

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Re: L-Arginine High Dose for E.D.
« Reply #1 on: July 29, 2019, 07:03:41 am »
There is some implications of causality for Shingles with L Arginine and I my self suffered from Shingles after using it at about 2000mg per day.
Age:60, Height 6' 3" weight 100KG
2014 Androderm Patches
2014-2016 Oral Andriol 160mg Daily
June 2016 Clomid/Serophene 12.5mg EOD
September 2016 no TRT all natural and supplements for the time being
February 2017 Testosterone cream 100mg daily

Sept 2016
Testosterone   8.2 nmol/l   9-38
Free Testosterone   239 pmol/l   L   250-800
SHBG:  14    nmol/L   9-60
Free Androgen index   586   >400
Oestradiol    112   pmol/L    <190
LH    2.6 IU/L Adult male   2 - 9 IU/L
FSH  1.4 IU/L Adult male L2 - 12 IU/L

22 November
T 6.8  nmol/L ( 9-38 ) L

March 2017
Testosterone:   45.0  nmol/L ( 9-38 ) H ( 1,323 ng/dl )
Free Testosterone:   1512  pmol/L ( 250-800 ) H
SHBG:   17  nmol/L ( 9-60 )
Plasma IGF-1:   227 ug/L ( 55-198 ) H
Plasma cortisol:   434 nmol/L ( 0600-1000 hrs 170-500 nmol/L )
HbA1c:   36 mmol/mol ( 20-40 )
LH:   <0.1 IU/L
FSH:   0.1 IU/L
DHT Plasma Dihydrotestosterone:   7455   pmol/L ( 223 ng/dl ) 
Reference Range Adult males  1000-6000 pmol/L

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Re: L-Arginine High Dose for E.D.
« Reply #1 on: July 29, 2019, 07:03:41 am »


Cataceous

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Re: L-Arginine High Dose for E.D.
« Reply #2 on: July 29, 2019, 11:13:29 am »
Shingles is only a concern if you've had chickenpox. Maybe you're young enough to have had the vaccine?
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 60, Ht: 5'10", Wt: 154 lbs
Protocol: 3.2 mg TE subQ qd, 2.4 mg TP subQ qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

HRT Guru

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Re: L-Arginine High Dose for E.D.
« Reply #3 on: July 29, 2019, 12:48:55 pm »
Arg is actually a very poor NO substrate donor, just a mere 40% or less survives pass through on the Liver, get's converted to Ornithine and Citrulline and back to Arg...not efficient.

Better results from Citrulline and kidney pass thru than with Arg/Liver.

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Re: L-Arginine High Dose for E.D.
« Reply #3 on: July 29, 2019, 12:48:55 pm »


golfboy307

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Re: L-Arginine High Dose for E.D.
« Reply #4 on: July 29, 2019, 02:44:38 pm »
I have had better luck with modest doses of Citrulline.  Any amount of Arginine over 750 mg tends to flare cold sores for me (Herpes-1). 
Age 51, 5'10, 155 lbs
Cholesterol 162 (HDL 59, LDL 87, Trigs 88, LDL-P 850)
Fasting Glucose 65 (down from 97 pre TRT)
A1C:  5.0 (down from 5.7 per TRT)
Homocysteine:  12.4 > 11.0 > 10.2 > 8.9 using B vitamin therapy.  MTHFR positive 

BP  120/78 (using improved diet and 10 mg Lisinopril ACE Inhibitor)  145/90 prior to meds.

Current protocol:  60 mg Test Cyp IM every 5 days.  No AI.
2/15/17 labs:  Total T (peak day): 1169 (250 - 1100 ng/dl).  Free T 198 pg/ML (46-225).  Sensitive E2: 40 High.  Previously 32. PSA 0.2  Hemocrit 44.2. SHBG: 32
9/15/18 labs:  Total T (trough day):  598 (250 -1100 ng/dl)  Free T 73.9 (46-225) Sensitive E2: 21  Hemocrit 43.7  SHBG 34
2/20/19 labs:  Total T (mid point):  776 (250 -1100 ng/dl) Free T 115.6 (46 - 224 pg/ml) Sensitive E2 24 (<29), DHT 43 (16-79 ng), DHEA-s 244 (70-495 mcg/dl)


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Flyingfool

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Re: L-Arginine High Dose for E.D.
« Reply #5 on: July 29, 2019, 11:11:40 pm »
I am taking L-citruline. Two capsules a day. Each capsule is 750 mg. I take one in the morning and the other at about 2 to 3 PM.

I seem to have noticed a bit of improvement with erection quality.
54 year old, 5-7 and 174 lbs.
exercise: nine really. Cancer & surgery & covid restriction closed swimming
Pool :(

Blood tested 2/9/21

Total = 614  ng/dL (250-827) up from 520
Free T= 13.68 (5.6- 21.0) measured
Free T TruT calc 19.9

SHBG= 31.9 (11.2-78.1)

Bio-avail= 321 (110-575)

Estradiol = <10 (11-44) male range
Estrone not measured

DHES = not measured
DHEA = not measured

Currently on 50mcg Synthroid (T4)
TSH = 0.937
Free T4 = 1.03 (0.78 - 2.19)= 17.7% of range
Free T3 = 3.73(2.77-5.27) = 38.4%  of range

Current protocol: 100mg DIM once per day. 

NOT on TRT.

HRT Guru

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Re: L-Arginine High Dose for E.D.
« Reply #6 on: July 31, 2019, 02:06:26 pm »
Arg has never aggravated HSV 1 or 2 that I have though I am on a daily suppressive therapy to manage it.

Mr.L

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Re: L-Arginine High Dose for E.D.
« Reply #7 on: July 31, 2019, 06:35:03 pm »
I think I remember PeakT caution against taking too much arginine. I take 1.5 grams daily split into three 500mg doses. I think it helps with vascularity but I could be wrong. Anyway, I think a lower dose is probably beneficial but you might run into problems with that chronic high dose. 

Joe Sixpack

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Re: L-Arginine High Dose for E.D.
« Reply #8 on: August 01, 2019, 04:12:23 am »
I get mini-shingles outbreaks if I take more than a gram.  Citruline does not cause me any problems.  But I also never noticed any benefit from Citruline (or arginine for that matter)
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

Kierkegaard

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Re: L-Arginine High Dose for E.D.
« Reply #9 on: August 21, 2019, 07:31:25 am »
Worth noting that Dr Jonathan Wright (one of the best in the nation) always recommends taking the amino acid lysine when taking citrulline or arginine to prevent shingles/herpes outbreaks, seeing how lysine can prevent herpes.

Also, there has been some research showing a powerful interaction effect between arginine or citrulline (I agree that the latter works better and also has a longer half life, but some people respond better to the former) and pycnogenol. 
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September 2015: Dx hypothyroidism, other adrenal hypofunction
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jason100

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Re: L-Arginine High Dose for E.D.
« Reply #10 on: September 03, 2019, 04:18:49 pm »
Question for those of you that have mentioned the shingles and herpes risk of arginine:

Does that risk still exist if you get high dosages of arginine from foods?

Research indicates that arginine can help sexual health when combined with L Citruline.

I have been using L Citruline with pine bark extract and get my argenine from pumpkin seeds and other high protein foods and have not had any issues for the two or three years that I've been taking it.

Flyingfool

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Re: L-Arginine High Dose for E.D.
« Reply #11 on: September 04, 2019, 03:40:34 pm »
I have been taking L-Citrulline twice a day for a while now. Maybe a month. I have NOT taken Arginine.

I have seemed to get more morning/nocturnal erections than before I was taking the L-Citrulline and they seem to be stiffer. So it seems to have been reasonably effective for me.

I would like to add beet juice, or capsules of beet powder. But have not done that yet.
54 year old, 5-7 and 174 lbs.
exercise: nine really. Cancer & surgery & covid restriction closed swimming
Pool :(

Blood tested 2/9/21

Total = 614  ng/dL (250-827) up from 520
Free T= 13.68 (5.6- 21.0) measured
Free T TruT calc 19.9

SHBG= 31.9 (11.2-78.1)

Bio-avail= 321 (110-575)

Estradiol = <10 (11-44) male range
Estrone not measured

DHES = not measured
DHEA = not measured

Currently on 50mcg Synthroid (T4)
TSH = 0.937
Free T4 = 1.03 (0.78 - 2.19)= 17.7% of range
Free T3 = 3.73(2.77-5.27) = 38.4%  of range

Current protocol: 100mg DIM once per day. 

NOT on TRT.

Mr.L

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Re: L-Arginine High Dose for E.D.
« Reply #12 on: September 04, 2019, 05:57:53 pm »
You know all of these supplements are great but the best medicine for your "hard on" is regular cardio (sprints, HITT, or even running and biking if you get your heart rate high enough and don't over do it) and a lowish fat diet with plenty of fruits and veggies (antioxidants). Chocolate (dark enough to be bitter), arugula, spinach, beets, blueberries, pomegranate etc. Resistance training and Kegels are a good idea as well. You should also play with it and keep it hard for about 15 minutes a day if you can. I do not recommend Jelquing because it can cause damage but you could modify the movement so it isn't as intense. This will get the blood flowing into that tissue bringing oxygen and other good stuff that your "one eyed trouser snake" needs. Finally get naked! If you have a significant other break those barriers and get naked and fuck, make sweet sweet love, do the deed or what ever you do. Get naked and touch each other, all over; don't underestimate foreplay for her or you. Worry less about your cock and more about being close and for a lot of you that will do wonders. For those of you with a legitimate problem I would recommend looking into Defy's soundwave therapy. I have read about this several years ago and it seems like a great non invasive way to get your wood back. But I will end this post by saying that most of us just need to get up and move! You need to make your heart work hard so your cock can get hard.     

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Re: L-Arginine High Dose for E.D.
« Reply #12 on: September 04, 2019, 05:57:53 pm »