I've had trouble with cyclical and ever increasing extreme fatigue, exhaustion and exercise intolerance for 10 years now. I've have Hashimoto's for 25 years, and RNP antibodies (MCTD) and was always an athlete. But treatment did not help the ever worsening prob and I'm now quite sedentary (not by choice) .
I first noticed that I could not bicycle 30 miles anymore, and chalked it up to "bad days" or getting older. But when distances reduced to 6 miles, then 3 miles followed by unreal exhaustion that can't be explained, and inability to get heart rate up above idle, it was pretty obvious something was very wrong. I'd go 4MPH and be flat out incapable of doing more. That's a universe away from 20 something racing speeds and 30+ mph sprints that were possible before this started.
I am also very low T. Testosterone treatment makes no difference what so ever with regard to this. Makes me horny, but does nothing for the severe energy deficit.
I've just been accurately diagnosed with Multiple Mitochondrial Dysfunction (although it's been suspected for years) . It's not necessarily genetic, possibly caused by Statins. It's not good news, it's rare, but it's good to finally know. Knowing means I now understand that I must not push myself into fatigue, as I've been told damage occurs due to oxidative stress. Staying within my energy envelope is the directive.
One thing I learned on my own is that Prednisone helps, especially when I have extended troubles. Interestingly, certain Mito diseases may be responsive to glucocorticoids.
Quote from NCBI: Mitochondrial dysfunction can be precipitated by drugs, Hypothyroidism, renal and liver impairment and diabetes are other risk factors. Whilst evidence in the literature points towards statin-induced mitochondrial dysfunction as the most likely cause of SAMS, the exact processes leading to mitochondrial dysfunction are not yet fully understood.
I should never have been put on statins. Being both Athletic and Hypothyroid. It's ruined my life.
In any case, I'm wondering if anyone here knows anything about this kind of disease?