Quantcast

Author Topic: ED since early 20s, hormone imbalance?  (Read 356 times)

StephCurryFtw

  • Full Member
  • ***
  • Posts: 218
  • 25,TRT@14, family:^Chol., low T, low thyro, etc...
    • View Profile
Re: ED since early 20s, hormone imbalance?
« Reply #15 on: May 16, 2021, 10:26:51 pm »
At least in men the anti-estrogenic effect of prolactin would be indirect—through reduced testosterone. But estrogen tends to increase prolactin.

Production of prolactin is controlled by two main hormones: dopamine and estrogen. These hormones send a message to the pituitary gland primarily indicating whether to begin or cease the production of prolactin. Dopamine restrains the production of prolactin, while estrogen increases it.
https://www.hormone.org/your-health-and-hormones/glands-and-hormones-a-to-z/hormones/prolactin

So would it be good for men to have low prolactin that isn’t outside the reference range?

See also:
Acute stimulation of prolactin release by estradiol: mediation by the posterior pituitary
https://www.peaktestosterone.com/How_To_Lower_Prolactin/
December 17th, 2020:

TT: 543.85 ng/dL (245-970 ng/dL)
FT: 11.82 pg/mL (47-293 pg/mL)
Prolactin: 25.76 ng/mL (3-13 ng/mL)
SHBG: 8.69 nmol/L (10-40 nmol/L)
E2: 25.26 pg/mL (10-40 pg/mL)
DHEA-S: 629.71 mg/dL (280-640 mg/dL)
Cortisol @ 8 A.M.: 23.64 mcg/dL (10-20 mcg/dL)
TSH: 2.38 mIU/L (0.5-4.15 mIU/L)
T3: 137.63 ng/dL (100-200 ng/dL)
T4: 1.39 ng/dL (0.8-1.8 ng/dL)
(Reverse) T3: 15.37 ng/dL (9.2-24.1 ng/dL)
FSH: 4.36 mIU/mL (1.5-12.4 mIU/mL)
LH: 3.66 IU/L (1.24-7.8 IU/L)

Cataceous

  • Administrator
  • Hero Member
  • *****
  • Posts: 6471
    • View Profile
Re: ED since early 20s, hormone imbalance?
« Reply #16 on: May 17, 2021, 11:31:33 am »
The main thing I'd be looking for is negative feedback resulting in a stable system. For example, increasing PRL --> decreasing T --> decreasing E2 --> decreasing PRL. This is partly why we get into trouble with TRT. This natural regulation no longer exists.

Regarding prolactin, as with most hormones, too little or too much may be a problem. Read this page: https://www.peaktestosterone.com/low_prolactin/
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 59, Ht: 5'10", Wt: 154 lbs
Protocol: 2.4 mg T propionate subQ qd, 3.2 mg T enanthate qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

Peak Testosterone Forum

Re: ED since early 20s, hormone imbalance?
« Reply #16 on: May 17, 2021, 11:31:33 am »


Testos_16

  • Newbie
  • *
  • Posts: 12
    • View Profile
Re: ED since early 20s, hormone imbalance?
« Reply #17 on: June 20, 2021, 05:51:59 pm »
Welcome, and sorry to see you're having such problems. That is a significant T/E2 imbalance, one of the worst that's been reported. It seems highly likely that this is contributing to your symptoms. There's one significant caveat, which is that the estradiol result should be confirmed by a sensitive test if that result did not come from one using LC/MS/MS technology. Though reliable overall, the standard test for estradiol can sometimes be fooled by substances such as C-reactive protein, incorrectly leading to higher values.

What is your SHBG? How is your weight? Excess body fat can contribute to aromatization and greater estradiol.

If the estradiol result is confirmed then you could actually be a candidate for aromatase inhibitor monotherapy. Aside from its other problems, TRT in your case would raise estradiol further.

Hi Cataceous
  Thanks for your reply. My SHBG is 11.9 nmol/L while the reference range is between 18.3-54.1
  I am 180cm tall 75kg BMI is around 24. I got fatty liver for years dont know if my hormone imbalance cause my liver problem or the other way around. I do exercise but didn't loss much weight.
  I feel tired even after 10 hours sleeping. Don't know what is wrong with my body.

Your SHBG of 11.9 nmol/l is very low for a person not on TRT and it could be the root cause. TRT tends to drive it further down which is problematic for low SHBG guys.

Peak Testosterone Forum

Re: ED since early 20s, hormone imbalance?
« Reply #17 on: June 20, 2021, 05:51:59 pm »