My troubles are likely different than yours. The mitochondrial dysfunction really knocks me down. Interestingly, caffeine helps as do certain amino acids. I find that Amino Energy by ON is a huge help. Along with prednisone and an occasional rev erba sarm type product.
My point is that this stuff started before I turned 50, and over the years I've been able to find products that help immensely. In fact, I'm feeling well lately.