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Author Topic: Low cortisol  (Read 162 times)

StephCurryFtw

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Low cortisol
« on: February 23, 2021, 07:15:36 am »
My AM cortisol came back low. Is this concerning being on TRT?  I checked through Defy. 
December 17th, 2020:

TT: 543.85 ng/dL (245-970 ng/dL)
FT: 11.82 pg/mL (47-293 pg/mL)
Prolactin: 25.76 ng/mL (3-13 ng/mL)
SHBG: 8.69 nmol/L (10-40 nmol/L)
E2: 25.26 pg/mL (10-40 pg/mL)
DHEA-S: 629.71 mg/dL (280-640 mg/dL)
Cortisol @ 8 A.M.: 23.64 mcg/dL (10-20 mcg/dL)
TSH: 2.38 mIU/L (0.5-4.15 mIU/L)
T3: 137.63 ng/dL (100-200 ng/dL)
T4: 1.39 ng/dL (0.8-1.8 ng/dL)
(Reverse) T3: 15.37 ng/dL (9.2-24.1 ng/dL)
FSH: 4.36 mIU/mL (1.5-12.4 mIU/mL)
LH: 3.66 IU/L (1.24-7.8 IU/L)

StephCurryFtw

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Re: Low cortisol TYPO...mean SHBG
« Reply #1 on: February 26, 2021, 08:22:08 am »
My bad guys, I mistyped.

My last labs showed my SHBG was around 8 units. I didnít mean to say cortisol. Forgive me. I was very sleep-deprived when I typed my last post. Is a SHBG of 7-9 pretty normal for a guy on 3 Androgel pumps daily? 
December 17th, 2020:

TT: 543.85 ng/dL (245-970 ng/dL)
FT: 11.82 pg/mL (47-293 pg/mL)
Prolactin: 25.76 ng/mL (3-13 ng/mL)
SHBG: 8.69 nmol/L (10-40 nmol/L)
E2: 25.26 pg/mL (10-40 pg/mL)
DHEA-S: 629.71 mg/dL (280-640 mg/dL)
Cortisol @ 8 A.M.: 23.64 mcg/dL (10-20 mcg/dL)
TSH: 2.38 mIU/L (0.5-4.15 mIU/L)
T3: 137.63 ng/dL (100-200 ng/dL)
T4: 1.39 ng/dL (0.8-1.8 ng/dL)
(Reverse) T3: 15.37 ng/dL (9.2-24.1 ng/dL)
FSH: 4.36 mIU/mL (1.5-12.4 mIU/mL)
LH: 3.66 IU/L (1.24-7.8 IU/L)

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Re: Low cortisol TYPO...mean SHBG
« Reply #1 on: February 26, 2021, 08:22:08 am »


Cataceous

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Re: Low SHBG
« Reply #2 on: February 26, 2021, 12:32:38 pm »
Single-digit SHBG is quite low, certainly not normal for a guy on typical TRT doses. The optimal level is around 30 nMol/L.

Have you had normal levels in the past? If not you may be predisposed to lower levels, perhaps genetically. This can make it tougher to get good results with TRT.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 59, Ht: 5'10", Wt: 154 lbs
Protocol: 2.4 mg T propionate subQ qd, 3.2 mg T enanthate qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

StephCurryFtw

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Re: Low SHBG
« Reply #3 on: March 01, 2021, 03:24:28 pm »
Single-digit SHBG is quite low, certainly not normal for a guy on typical TRT doses. The optimal level is around 30 nMol/L.

Have you had normal levels in the past? If not you may be predisposed to lower levels, perhaps genetically. This can make it tougher to get good results with TRT.

I have had SHBG levels below 10 even prior to TRT. It has haunted me.
December 17th, 2020:

TT: 543.85 ng/dL (245-970 ng/dL)
FT: 11.82 pg/mL (47-293 pg/mL)
Prolactin: 25.76 ng/mL (3-13 ng/mL)
SHBG: 8.69 nmol/L (10-40 nmol/L)
E2: 25.26 pg/mL (10-40 pg/mL)
DHEA-S: 629.71 mg/dL (280-640 mg/dL)
Cortisol @ 8 A.M.: 23.64 mcg/dL (10-20 mcg/dL)
TSH: 2.38 mIU/L (0.5-4.15 mIU/L)
T3: 137.63 ng/dL (100-200 ng/dL)
T4: 1.39 ng/dL (0.8-1.8 ng/dL)
(Reverse) T3: 15.37 ng/dL (9.2-24.1 ng/dL)
FSH: 4.36 mIU/mL (1.5-12.4 mIU/mL)
LH: 3.66 IU/L (1.24-7.8 IU/L)

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Re: Low SHBG
« Reply #3 on: March 01, 2021, 03:24:28 pm »


StephCurryFtw

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Re: Low SHBG
« Reply #4 on: March 01, 2021, 03:25:36 pm »
Single-digit SHBG is quite low, certainly not normal for a guy on typical TRT doses. The optimal level is around 30 nMol/L.

Have you had normal levels in the past? If not you may be predisposed to lower levels, perhaps genetically. This can make it tougher to get good results with TRT.

My dad and brother have low SHBG just like I do and my dad has low TT and FT from low LSH/FSH exactly like me. There has to be a genetics-component.
December 17th, 2020:

TT: 543.85 ng/dL (245-970 ng/dL)
FT: 11.82 pg/mL (47-293 pg/mL)
Prolactin: 25.76 ng/mL (3-13 ng/mL)
SHBG: 8.69 nmol/L (10-40 nmol/L)
E2: 25.26 pg/mL (10-40 pg/mL)
DHEA-S: 629.71 mg/dL (280-640 mg/dL)
Cortisol @ 8 A.M.: 23.64 mcg/dL (10-20 mcg/dL)
TSH: 2.38 mIU/L (0.5-4.15 mIU/L)
T3: 137.63 ng/dL (100-200 ng/dL)
T4: 1.39 ng/dL (0.8-1.8 ng/dL)
(Reverse) T3: 15.37 ng/dL (9.2-24.1 ng/dL)
FSH: 4.36 mIU/mL (1.5-12.4 mIU/mL)
LH: 3.66 IU/L (1.24-7.8 IU/L)

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Re: Low SHBG
« Reply #4 on: March 01, 2021, 03:25:36 pm »