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Author Topic: SHBG affected by Enclomiphene and Zuclomiphene?  (Read 696 times)

tLearner

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SHBG affected by Enclomiphene and Zuclomiphene?
« on: May 07, 2021, 09:06:28 am »
Is there proof the enclomiphene doesn't raise SHBG levels?
If so has this been proven in a range of people with different starting points eg. high TT, high SHBG OR low TT, low SHBG?

Thanks

Cataceous

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Re: SHBG affected by Enclomiphene and Zuclomiphene?
« Reply #1 on: May 07, 2021, 11:13:28 am »
For the benefit of others I'll include the link I posted over at ExcelMale: https://www.sciencedirect.com/science/article/abs/pii/S1743609515303829
This small study found minimal change in SHBG with use of enclomiphene. The subjects were hypogonadal men with a mean age of 46 years.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 60, Ht: 5'10", Wt: 154 lbs
Protocol: 4.5 mg T propionate subQ qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene q4d
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

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Re: SHBG affected by Enclomiphene and Zuclomiphene?
« Reply #1 on: May 07, 2021, 11:13:28 am »


James

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Re: SHBG affected by Enclomiphene and Zuclomiphene?
« Reply #2 on: June 08, 2021, 07:16:24 am »
In general, in any study involving changes in SHBG, they are always studying women with average levels of SHBG.  Rarely, they are studing men with normal levels of SHBG.

I know of not one single study where a cohort involved only people with 15 nmol/L or less.

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Re: SHBG affected by Enclomiphene and Zuclomiphene?
« Reply #2 on: June 08, 2021, 07:16:24 am »