Got my Rhein Labs Results Back and they are TELLING!!!
This is a good reference to read prior to looking at these results.http://www.rheinlabs.com/rhien_images/05_il/05_origSter.pdf
Estrone (E1) μg/24hrs 4.7 3 - 12
Estradiol (E2) μg/24hrs 2.2 0 - 7
Estriol (E3) μg/24hrs 8.6 1 - 16
Total Estrogens μg/24hrs 15 4 - 22
Testosterone μg/24hrs LOW 4.9 45 - 85
Dihydrotestosterone (DHT) μg/24hrs 0.8 0 - 13
Androstanediol μg/24hrs 60 48 - 578 s
Androstenedione μg/24hrs 3.7 Not Established
DHEA μg/24hrs 1272 5 - 1476
Androstenetriol (5-AT) μg/24hrs 617 42 - 710
Androsterone (AN) μg/24hrs 2889 798 - 4705
11b-OH-Androsterone (OHAN) μg/24hrs 1418 461 - 1692
Etiocholanolone (ET) μg/24hrs HIGH 3356 689 - 3252
11b-OH-Etiocholanolone (OHET) μg/24hrs 575 134 - 1186
Pregnanediol (PD) μg/24hrs 458 32 - 501
5-Pregnenetriol (5-PT) μg/24hrs 514 28 - 1062
Cortisone (E) μg/24hrs 238 92 - 366 s
THE μg/24hrs 5525 1365 - 5788
THB μg/24hrs HIGH 329 32 - 238
5a-THB μg/24hrs 499 135 - 588
THA μg/24hrs HIGH 399 52 - 277
Cortisol (F) μg/24hrs 101 35 - 168
Working on my hypotheses that I have a clearance issue and not a production issue, the data seems to indicate that could be the case.
One caveat. My doctor had me on clomiphene that I stopped about 2 weeks prior to this testing. My serum tests did show slightly elevated LH so it would seem to indicate my testosterone levels were a little elevate from it still. I do not think it makes a difference because the MW of Clomifene is different enough that it should not interfere with these tests via GC/MS
Specifically my historical serum Testosterone and Cortisol and DHEA levels have been low or low/normal along with low or low/normal SHBG levels.
Based on my observation, it looks like the data would be supportive of my hypothesis.
The key findings I see are
1) Low serum levels with high levels of Testosterone and Cortisol Metabolites in urine.
2) Low/Normal serum DHEA with High/Normal Urine DHEA
It would seem that the combined effect of clearance of Testosterone and Cortisol precursors could be as much of an issue as clearance and metabolism.
Since Etiocholanone is the primary metabolite in my urine, inhibiting 5-beta reductase could be a possible way to slow down the metabolism of Testosterone.
Question? Can you inhibit 5-beta reductase without inhibiting 5-alpha reductase. The reality is men with low SHBG have little DHT anyway because Testosterone doesnt hang around long enough to raise these levels.http://www.jbc.org/content/early/2009/06/09/jbc.C109.016931
The role of this enzyme also seems to be involved in the Adenosine Pathways which I have hypothesized is the cause of fatigue in these cases as well, and why caffeine can help!http://www.ncbi.nlm.nih.gov/pubmed/20164566
This is a double whammy that I wasn't expecting and could explain why DHEA and Pregnenolone are so helpful in low SHBG men by addressing the precursor clearance issues.