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Author Topic: DNP - 2,4 DiNitrophenol  (Read 16592 times)

Blade78

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DNP - 2,4 DiNitrophenol
« on: July 24, 2012, 10:53:30 pm »
http://www.psychologytoday.com/articles/201112/how-save-your-brain

I wonder, does 2,4 DiNitrophenol affect free radicals?
I thought so, and thats why, without caloric restriction, you can likely get a longer lifespan using minimal DNP
http://www.ncbi.nlm.nih.gov/pubmed/20958788

http://www.psychologytoday.com/artic...ave-your-brain

Unfortunately, rogue, unbound oxygen molecules—free radicals—that invariably form during energy metabolism are toxic to body cells, essentially causing them to rust over time. Normally, the hemoglobin molecule in blood regulates oxygen levels throughout the body so that cells are not overexposed to it. Aging also weakens our natural defenses against free radicals, putting all our cells (including neurons) at risk.

Antioxidant molecules are abundant in nature; plants maintain elaborate systems of them, and they are found notably in colorful fruits and vegetables (compounds like vitamins A, C, and E, beta carotene, and capsaicin, the spice in chili peppers). A diet rich in antioxidants combats the oxidative stress we are constantly under.

In the brain, antioxidants slow neurodegeneration. "The chemicals that give fruits their color are exactly what we want to protect us from oxygen," says Wenk. In fact, by eating foods rich in antioxidants, we're taking advantage of the way another life-form has devised to defend itself against environmental harm. From their own sources of proteins and carbohydrates, plant cells synthesize the chemicals we recognize as antioxidants as shields against bacteria, viruses, and the oxidative stress resulting from exposure to ultraviolet light or the toxin ozone.

Because of the basic similarities of evolved life processes, the plant protectors can also help human cells from showing the wear and tear of existence. Blueberries, broccoli, grapes, prunes, strawberries, spinach, artichokes, apples—all contain large amounts of antioxidants, as do herbs and spices like rosemary, turmeric, thyme, and oregano. Bright, yellow-orange turmeric is a classic ingredient in the curries that are a staple of Indian cooking. Please note: The incidence of Alzheimer's disease in India is one-sixth that of the U.S.
« Last Edit: July 25, 2012, 04:24:44 am by PeakT »
“Don’t you feel good when you go to the gym?’ Not at all. There’s too many people in-shape there. When I go to McDonald’s I feel great. At McDonald’s I’m Matthew McConaughey.” --Jim Gaffigan - Mr. Universe

PeakT

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Re: DNP - 2,4 DiNitrophenol
« Reply #1 on: July 25, 2012, 04:26:45 am »
I think your general topic here is antioxidants and decreasing "rusting" of the body or net oxidative load. 

Of course, I don't think there is anyone who thinks that antioxidant protection isn't incredibly important.  And getting those from food can help significantly.  However, just as important is increasing the bodies own natural antioxidants such as glutathione, SOD, etc.
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Re: DNP - 2,4 DiNitrophenol
« Reply #1 on: July 25, 2012, 04:26:45 am »


Blade78

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Re: DNP - 2,4 DiNitrophenol
« Reply #2 on: July 25, 2012, 10:05:12 am »
I think your general topic here is antioxidants and decreasing "rusting" of the body or net oxidative load. 

Of course, I don't think there is anyone who thinks that antioxidant protection isn't incredibly important.  And getting those from food can help significantly.  However, just as important is increasing the bodies own natural antioxidants such as glutathione, SOD, etc.
I wasnt making a thread asking if antioxidants are good or bad?  I thought someone would be able to confirm that DNP reduces ROS(reactive oxygen species) same as Caloric restriction but without the 30% reduction in calories.  so can I eat at maintenance and take DNP and emulate CR?

I'm not sure this thread is a good thing,  DNP isnt a direct antioxidant.(I dont think,which is why I made the post I did)
An antioxidant is a molecule that inhibits the oxidation of other molecules
When I lost 67lbs in 10 weeks, I took DNP and did a lot of walking, before taking a mitochondrial uncoupler, I learned a lot about it.  I know a lot about DNP and I'm confident someone is going to say how DNP is going to kill me or some other BS, same as people don't understand ephedrine
Ephdrine meets my criteria, and to most extent so does DNP, for a good drug.
A criteria for a good drug are that it should be inexpensive, available, effective, and safe (at least relatively speaking, there are risks with any  drugs).
Ephedrine, much more than DNP, is resticted by the law. Which is illogical as the government to restrict its sale, yet cigarettes and alcholol are freely given out in massive quantities.
http://www.drumlib.com/dp/000002.htm shows how Ephedrine works



My question is more about antioxidants, can you have too many?
“Don’t you feel good when you go to the gym?’ Not at all. There’s too many people in-shape there. When I go to McDonald’s I feel great. At McDonald’s I’m Matthew McConaughey.” --Jim Gaffigan - Mr. Universe

PeakT

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Re: DNP - 2,4 DiNitrophenol
« Reply #3 on: July 25, 2012, 01:29:27 pm »
I can't find it but there was a researcher who found by giving too many antioxidants you could potentially vasoconstrict vessels rather than vasodilate them.  Unfortunately, I can't find the reference anywhere.  I will try to remember where that is...

And, yeah, I know who that "someone" is - will read a bit more on that.  I don't have time to research as much as I'd like to so post a little more if you have time as to why you think this is all good...
« Last Edit: July 25, 2012, 01:55:00 pm by PeakT »
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Re: DNP - 2,4 DiNitrophenol
« Reply #3 on: July 25, 2012, 01:29:27 pm »


Blade78

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Re: DNP - 2,4 DiNitrophenol
« Reply #4 on: July 26, 2012, 12:00:06 pm »
I can't find it but there was a researcher who found by giving too many antioxidants you could potentially vasoconstrict vessels rather than vasodilate them.  Unfortunately, I can't find the reference anywhere.  I will try to remember where that is...

And, yeah, I know who that "someone" is - will read a bit more on that.  I don't have time to research as much as I'd like to so post a little more if you have time as to why you think this is all good...
I dont know who that "someone" is specifically, but there's always a "someone"

I also vaguely remember hearing about antioxidants potentially being bad, that's why I like DNP, it's not an antioxidant, but it causes the same results: decrease in free radicals.
DNP has a half life of 36 hours you just dont want to megadose it because you'll end up dead
just make sure you get a  legit/clean source for the drug.
Start with small doses to see how it makes you feel, as it will make you lethargic and short of breath.  This is which is why EC stack is useful  both to boost your BMR(3%) and as a broncodilator   
« Last Edit: July 26, 2012, 12:01:59 pm by watchntv »
“Don’t you feel good when you go to the gym?’ Not at all. There’s too many people in-shape there. When I go to McDonald’s I feel great. At McDonald’s I’m Matthew McConaughey.” --Jim Gaffigan - Mr. Universe

feelgood

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Re: DNP - 2,4 DiNitrophenol
« Reply #5 on: July 26, 2012, 12:48:30 pm »
wha???

"I also vaguely remember hearing about antioxidants potentially being bad"

every time i think i'm killing it in terms of what i *should* be doing, you guys throw something like that out there.

WTF? never heard that? I thought you wanted antioxidants as much as possible?

so all those fruits and veggies i eat, all the super green food powder i drink, etc might not be all good? yeah i really can't believe that.

PeakT

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Re: DNP - 2,4 DiNitrophenol
« Reply #6 on: July 26, 2012, 02:52:17 pm »
Starry:

Don't panic.  Think about this:  almost all the supercultures around the globe eat an abundance of antioxidants from fruits, vegetables and in some cases whole grains.  And they fantastically - much better than us.  They have almost zero heart disease, very low rates of cancer, virtually no autoimmune disease or Alzheimers and increased longevity.

Again, I am just telling you what one researcher was concerned about.  But, again, I don't know any expert who would tell you to avoid a clean, whole foods diet with abundant anti-oxidants and didn't mean to imply that.

I'll see if I can find the reference so we can find the context.
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feelgood

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Re: DNP - 2,4 DiNitrophenol
« Reply #7 on: July 26, 2012, 03:24:47 pm »
thanks Peak. I think i was cranky this morning, but i was still being at least a tad tongue-in-cheek

thanks for talking me off the ledge :)

PeakT

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Re: DNP - 2,4 DiNitrophenol
« Reply #8 on: July 26, 2012, 03:49:12 pm »
thanks Peak. I think i was cranky this morning, but i was still being at least a tad tongue-in-cheek

thanks for talking me off the ledge :)

Np.  It all has to do with hydrogen peroxide.  I am actually to write a short page on the subject.  Stay tuned...
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Re: DNP - 2,4 DiNitrophenol
« Reply #9 on: July 27, 2012, 05:23:54 pm »
thanks Peak. I think i was cranky this morning, but i was still being at least a tad tongue-in-cheek

thanks for talking me off the ledge :)

No worries and you inspired me to write some more information about the subject: 

http://www.peaktestosterone.com/Antioxidants_Heart
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PeakT

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Re: DNP - 2,4 DiNitrophenol
« Reply #10 on: July 27, 2012, 05:32:44 pm »
Watchntv:

Hey, this is one strange compound.  So I would guess you are most int'd in it as a dietary aid?

Anyway, this sounds like potent stuff:  you have to be careful messing with mitochondria, don't you think?  It looks like you have to be careful with dosing as it has lead to quite a few deaths:

http://www.springerlink.com/content/vm25m7335516240p/

This poor guy died within just a couple of hours:

http://emj.bmj.com/content/27/8/639.short

And Wiki lists it as an environmental contaminant due to its potential toxicity:

http://en.wikipedia.org/wiki/2,4-Dinitrophenol

Anyway, do you know anyone taking it?  Looks like it's scary enough that Amazon won't sell it.

THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
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If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Blade78

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Re: DNP - 2,4 DiNitrophenol
« Reply #11 on: August 05, 2012, 12:41:20 am »
Watchntv:

Hey, this is one strange compound.  So I would guess you are most int'd in it as a dietary aid?

Anyway, this sounds like potent stuff:  you have to be careful messing with mitochondria, don't you think?  It looks like you have to be careful with dosing as it has lead to quite a few deaths:

http://www.springerlink.com/content/vm25m7335516240p/

This poor guy died within just a couple of hours:

http://emj.bmj.com/content/27/8/639.short

And Wiki lists it as an environmental contaminant due to its potential toxicity:

http://en.wikipedia.org/wiki/2,4-Dinitrophenol

Anyway, do you know anyone taking it?  Looks like it's scary enough that Amazon won't sell it.
People die from all sorts of things, DNP causes death because people OD on the drug,it has a 36 hour half life, it impairs ATP formation via uncouples the electron transport chain, so instead of forming ATP, heat is made..
It's AMES test negative, so eve though it is a phenol, its not gonna cause cancer

I know all kinds of guys who use it.  wiki isnt a realiable source for information on this topic
I dont think its legal to sell across state lines, and besides, I only use it for research on monkeys....that I keep in my garage.....or something like that.
“Don’t you feel good when you go to the gym?’ Not at all. There’s too many people in-shape there. When I go to McDonald’s I feel great. At McDonald’s I’m Matthew McConaughey.” --Jim Gaffigan - Mr. Universe

PeakT

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Re: DNP - 2,4 DiNitrophenol
« Reply #12 on: August 05, 2012, 01:35:27 am »
Okay, but to me this is a supplement that is very powerful and I'm just saying that I doubt we really know what we're doing yet and what long term effects it causes.  Everyone has different risk levels though...
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Blade78

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Re: DNP - 2,4 DiNitrophenol
« Reply #13 on: March 11, 2013, 10:57:26 pm »
Okay, but to me this is a supplement that is very powerful and I'm just saying that I doubt we really know what we're doing yet and what long term effects it causes.  Everyone has different risk levels though...
everything you take can be regarded as a supplement
DNP has been used/studies since the 1930s, and shown little risk to men, especially healthy men.....the biggest issue with DNP is that people tend to think more=better
 which with DNP will outright cook you from the inside

at any case, I havent used my heat all winter,,,,and I wander around outside in the snow in gloves and, t-shirt and shorts.........
“Don’t you feel good when you go to the gym?’ Not at all. There’s too many people in-shape there. When I go to McDonald’s I feel great. At McDonald’s I’m Matthew McConaughey.” --Jim Gaffigan - Mr. Universe

PeakT

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Re: DNP - 2,4 DiNitrophenol
« Reply #14 on: March 12, 2013, 02:24:54 am »

everything you take can be regarded as a supplement
DNP has been used/studies since the 1930s, and shown little risk to men, especially healthy men.....the biggest issue with DNP is that people tend to think more=better
 which with DNP will outright cook you from the inside

at any case, I havent used my heat all winter,,,,and I wander around outside in the snow in gloves and, t-shirt and shorts.........

Does DNP actually fire up metabolism that much or are you just joking?
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If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: DNP - 2,4 DiNitrophenol
« Reply #14 on: March 12, 2013, 02:24:54 am »