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Author Topic: How to Do Testosterone Cypionate Injections + Schedules and Methods  (Read 100604 times)

Kierkegaard

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #60 on: March 19, 2016, 06:51:56 am »
So if testosterone only trt might lower little bit of cortisol in physiological amounts of supplementing t,  does sypraphysiological amount of testosterone lower even more? Let's say 250mg of testosterone weekly?

It could cuzz it would shut you down harder according to that school of thought.  Keep in mind that that is not something out of the research though but anecdotal.

Peak, I'm sure you've seen me ramble about this study: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470424/

The discussion section contains other articles that reveal the same thing but also speak about mechanisms, such as reduction of adrenal cascade enzymes, a partial form that's fully seen in congenital adrenal hyperplasia.  This is a very well-done study, so I don't see how it can be easily put aside.  I'll be asking Mariano about it when I meet with him in a week (he's previously written, years before this article came out, how testosterone can lower cortisol and cause problems, but that it does this through reducing ACTH, not raising it).

As for the original question, I'd say that the reductions in cortisol are going to be small and in many cases not noticeable in general and provided that you're at a healthy cortisol level to begin with.  Of course, speaking generally means you have room for individual variation, and this is where anecdotes come in: I've talked with or read about multiple guys who had clear significant reductions in cortisol asl measured by salivary collections.  I'm talking like 40-50% reductions in morning levels.  These, I think, are pretty uncommon.  At the same time, I think it's absolutely imperative to measure all your major hormones (thyroid, insulin, adrenal) when measuring testosterone given the interrelatedness of the endocrine system, so you minimize the odds of putting a bandaid on something and creating a wound in another area. 

And yeah, I think you should see a dose-dependent relationship, but no studies have unveiled this, so that's totally my opinion.  I know that my DHEA-S has been higher the higher my testosterone dose, indicating more ACTH because of lower cortisol given the effect of testosterone replacement on these variables.  But that's just me, not the general.
« Last Edit: March 19, 2016, 06:54:21 am by Kierkegaard »
"The same thing that makes you live can kill you in the end." -- Neil Young

March 2014: Dx low T (158ng/dl)
September 2015: Dx hypothyroidism, other adrenal hypofunction
2016: chronic fatigue, unspecified

Depression and anxiety guide: http://www.peaktestosterone.com/Help_Anxiety_Depression

PeakT

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #61 on: June 13, 2016, 05:30:12 pm »
I split out a post about a study (that I believe Sam posted many moons ago) showing what happens as the dosage is ramped up from 50 to 300:

http://www.peaktestosterone.com/forum/index.php?topic=10253.0
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #61 on: June 13, 2016, 05:30:12 pm »


PeakT

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #62 on: November 24, 2016, 03:45:24 pm »
Good thread on how to inject into the delts:

http://www.peaktestosterone.com/forum/index.php?topic=11454.0
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

PeakT

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #63 on: December 03, 2016, 10:36:05 pm »
Thx to Croaker for this:  he posted some pics as to where to inject subQ in the gluts.  Check out the links below:

"The upper outside quadrant on either side.   

For example -- http://fitnessedge.net/guides/steps-to-self-administering-a-subcutaneous-injection/    or  https://www.bd.com/resource?IDX=29219

I don't feel a thing at these sites but go lower and it will really sting.    Also it really cannot be done self-injecting - my wife does it for me."
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #63 on: December 03, 2016, 10:36:05 pm »


hockey21

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #64 on: August 14, 2017, 01:23:10 pm »
Hi All!

Doing my first injection today - Subq. 100mg/ week

Question - my pharmacy gave me 27 gauge needles. Are these too thin? Is that okay? I'm a very lean guy (5'10, 143 lbs). Any tips?

I've watched lots of videos but don't have too much stomach fat.

Thanks!

Kierkegaard

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #65 on: August 14, 2017, 02:29:38 pm »
Hi All!

Doing my first injection today - Subq. 100mg/ week

Question - my pharmacy gave me 27 gauge needles. Are these too thin? Is that okay? I'm a very lean guy (5'10, 143 lbs). Any tips?

I've watched lots of videos but don't have too much stomach fat.

Thanks!

I use 29 g needles for subq injections.  I wouldn't worry too much about "only" 27 g, though.  We generally rec injecting more frequently than once per week, which is why subq injections are recommended; every 3 days is a good number for most guys, and note that we've found that the more frequently you inject the less T you need.  So instead of just injecting 42 mg E3D, you might consider rolling that down to 30-35 mg E3D.  This is something the doctors who come at the forum have noticed as well. 
"The same thing that makes you live can kill you in the end." -- Neil Young

March 2014: Dx low T (158ng/dl)
September 2015: Dx hypothyroidism, other adrenal hypofunction
2016: chronic fatigue, unspecified

Depression and anxiety guide: http://www.peaktestosterone.com/Help_Anxiety_Depression

hockey21

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #66 on: August 15, 2017, 02:28:35 pm »
I stopped by my PCP today (who ordered the T) to have them do my first injection.

They used a 25g for the SubQ and I won't lie - it is definitely tender/ sore in the area.

Maybe I'm too lean for a 25?

Thanks

Kierkegaard

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #67 on: August 15, 2017, 09:04:38 pm »
I stopped by my PCP today (who ordered the T) to have them do my first injection.

They used a 25g for the SubQ and I won't lie - it is definitely tender/ sore in the area.

Maybe I'm too lean for a 25?

Thanks

Go to the Vitality Medical and order 29g 1 ml insulin or tuberculosis syringes. There's no reason you can't do them yourself. You're probably feeling sore from having so dang much injected subq at once. Again, people use subq to inject more frequently at lower amounts. If you insist on doing 100 mg at once, split the injection into two separate locations on your abdominal area or just do intramuscular injections.
"The same thing that makes you live can kill you in the end." -- Neil Young

March 2014: Dx low T (158ng/dl)
September 2015: Dx hypothyroidism, other adrenal hypofunction
2016: chronic fatigue, unspecified

Depression and anxiety guide: http://www.peaktestosterone.com/Help_Anxiety_Depression

PeakT

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #68 on: August 20, 2017, 03:20:05 pm »
I stopped by my PCP today (who ordered the T) to have them do my first injection.

They used a 25g for the SubQ and I won't lie - it is definitely tender/ sore in the area.

Maybe I'm too lean for a 25?

Thanks

Yeah, just increase your frequency:  some guys do EOD, some MWF, etc.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Roger

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #69 on: September 27, 2017, 10:42:17 am »
If I want to stay at 100mg per week of test cyp, what would be the proper dosage if I start SubQ injections EOD? 20mg, 25mg, or 30mg?
« Last Edit: September 28, 2017, 05:48:06 am by Roger »
Age: 53
Height: 5' 8"
Weight: 185 lbs
Body Fat: 10-13%
50 mg test cyp IM twice per week

doin it

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #70 on: September 27, 2017, 01:07:25 pm »

Age: 71

Guys,
I bought Lee Myer's book and it contains a lot of great info but am confused on one point: several times in the book, Lee says he does subq EOD and then several times in the book, he says he does 2 x per week, which one does he REALLY do?
Thanks,
Doin it

Cataceous

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #71 on: September 28, 2017, 12:08:05 pm »
If I want to stay at 100mg per week of test cyp, what would be the proper dosage if I start SubQ injections EOD? 20mg, 25mg, or 30mg?

Well 100 mg/3.5 ~= 28.6 mg, so the 30 mg dose would put you closest (at 105 mg per week). But it's frequently said that you can use a lower dose when injecting more often, so I would go for the 25 mg dose.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 60, Ht: 5'10", Wt: 154 lbs
Protocol: 3.2 mg TE subQ qd, 2.4 mg TP subQ qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

PeakT

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #72 on: September 28, 2017, 04:45:57 pm »

Age: 71

Guys,
I bought Lee Myer's book and it contains a lot of great info but am confused on one point: several times in the book, Lee says he does subq EOD and then several times in the book, he says he does 2 x per week, which one does he REALLY do?
Thanks,
Doin it

I am currently doing every other day subQ.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

doin it

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #73 on: September 29, 2017, 03:52:27 am »
Age: 71
Primary Hypogonadism
Low T
High LH
High FSH
Medium high Prolactin
High SHBG
E2=22
5'10, 167

Thanks for your response, Lee.

Have tried T cream (disliked) and T Alc Gel which did not much but put DHT over the top (what a number that was), off and on over the last 5 years.

Starting SubQ T soon with the "start low and go slow" mantra.  Also recognizing that Dr. Crisler says that 80 mg SubQ is equivalent to 100 mg IM (which puts most hypo guys in the 500 to 800 range).

I have all the above readings for the last 25 years and when I felt best, was around 500 to 600 ng.

 So, will begin with 50 mg per week which should put me in that range.  I am trying to figure out whether to do every day, EOD, or 2x / week.

IMOPO, recognizing that LH and T release are pulsatile, diurnal, are highest in the am, and then diminish the rest of the day (mine drops by about 22 % by 4:30 pm), I think that the body organs and all those billions of cells get a break from the T in the evening and very early am (B4 3 am).   I have not read this anywhere, just my opinion (do they NEED a break?).  So, I think I would like to do daily but am concerned about all those holes (365 per year).  Is anyone doing SubQ daily?  If so, any comments would be more than welcome.

Thanks,
Doin it

PeakT

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Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #74 on: September 29, 2017, 12:55:50 pm »
Age: 71
Primary Hypogonadism
Low T
High LH
High FSH
Medium high Prolactin
High SHBG
E2=22
5'10, 167

Thanks for your response, Lee.

Have tried T cream (disliked) and T Alc Gel which did not much but put DHT over the top (what a number that was), off and on over the last 5 years.

Starting SubQ T soon with the "start low and go slow" mantra.  Also recognizing that Dr. Crisler says that 80 mg SubQ is equivalent to 100 mg IM (which puts most hypo guys in the 500 to 800 range).

I have all the above readings for the last 25 years and when I felt best, was around 500 to 600 ng.

 So, will begin with 50 mg per week which should put me in that range.  I am trying to figure out whether to do every day, EOD, or 2x / week.

IMOPO, recognizing that LH and T release are pulsatile, diurnal, are highest in the am, and then diminish the rest of the day (mine drops by about 22 % by 4:30 pm), I think that the body organs and all those billions of cells get a break from the T in the evening and very early am (B4 3 am).   I have not read this anywhere, just my opinion (do they NEED a break?).  So, I think I would like to do daily but am concerned about all those holes (365 per year).  Is anyone doing SubQ daily?  If so, any comments would be more than welcome.

Thanks,
Doin it

Noted.  Can you please create a separate thread for this?  PM me if you don't know how to do it.  This thread is more for the raw mechanics and protocols of injections.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Peak Testosterone Forum

Re: How to Do Testosterone Cypionate Injections + Schedules and Methods
« Reply #74 on: September 29, 2017, 12:55:50 pm »