Dunno what the ideal ratio is (I'd shoot for at least 30:1 T to E2), but I think the ratio is important, particularly in that it really determines the "ratio" of your femininity to masculinity. I'm speaking purely theoretically here. You can't speak of an "absolute" value for femininity or masculinity, given that each and every person has a little of both, which means it's a ratio that determines how much of one is more dominant than the other. Now, the worst case here wouldn't be 50:50 (although that would arguably have pretty bad sides for males or females), but when both T and E approach zero, which is where I was for a few weeks after a doctor fucked up and put me on fluoxetine, which zipped my already virtually nonexistent T level, and with it my E2. Ungodly terrible sides, including anxiety, suicidal depression, fatigue, and insomnia like you wouldn't believe.