Don't know how many of you follow anti-aging news, but this is a very interesting one from Life Extension Foundation. Of course, the mitochondria are ground zero to aging and they have found a form of B3 that directly converts into a compound called, which in turn activates the key anti-aging enzymes in the body called sirutins. Resveretrol and CR all act on these enzymes as you'll read in the article below:http://www.lef.org/magazine/2014/11/the-youth-restoring-benefits-of-nad/page-01
"It has long been known that NAD+ plays an important role in transferring energy released from glucose and fatty acids to the mitochondria so that it can be converted into cellular energy.2,9 Without sufficient NAD+, energy transfer in the cells breaks down, resulting in age-accelerating mitochondrial dysfunction.5,10,11
NAD+ is an essential cofactor of key enzymes responsible for longevity called sirtuins.5,12,13 While resveratrol is well known for sirtuin activation, evidence indicates it does so indirectly,14,15 whereas NAD+ directly activates sirtuins to regulate the genes of aging.2,16
Sirtuins, specifically SIRT1 and SIRT3, are intimately related to longevity through their control of gene expression and require NAD+ for their activity.2,3,10,17-19
Research into the sirtuins continues to yield substantial information on how to control aging. By activating these sirtuins, we’re able to gain control over one of our body’s anti-aging “switches.” SIRT enzymes “turn off” certain genes that promote aging, such as those involved in inflammation,20,21 in fat synthesis and storage,22,23 and in blood sugar management.3,22,23
SIRT enzymes are activated by calorie restriction, the proven means of reliably extending life span in all organisms.2,24 The way calorie restriction activates anti-aging sirtuins is by increasing cellular NAD+.2,25,26"