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Author Topic: Anti-Aging Breakthrough? NAD+ and Berberine Boost Sirutins  (Read 2611 times)

PeakT

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Anti-Aging Breakthrough? NAD+ and Berberine Boost Sirutins
« on: October 20, 2014, 07:37:02 am »
Don't know how many of you follow anti-aging news, but this is a very interesting one from Life Extension Foundation.  Of course, the mitochondria are ground zero to aging and they have found a form of B3 that directly converts into a compound called, which in turn activates the key anti-aging enzymes in the body called sirutins.  Resveretrol and CR all act on these enzymes as you'll read in the article below:

http://www.lef.org/magazine/2014/11/the-youth-restoring-benefits-of-nad/page-01

"It has long been known that NAD+ plays an important role in transferring energy released from glucose and fatty acids to the mitochondria so that it can be converted into cellular energy.2,9 Without sufficient NAD+, energy transfer in the cells breaks down, resulting in age-accelerating mitochondrial dysfunction.5,10,11

NAD+ is an essential cofactor of key enzymes responsible for longevity called sirtuins.5,12,13 While resveratrol is well known for sirtuin activation, evidence indicates it does so indirectly,14,15 whereas NAD+ directly activates sirtuins to regulate the genes of aging.2,16

Sirtuins, specifically SIRT1 and SIRT3, are intimately related to longevity through their control of gene expression and require NAD+ for their activity.2,3,10,17-19

Research into the sirtuins continues to yield substantial information on how to control aging. By activating these sirtuins, we’re able to gain control over one of our body’s anti-aging “switches.” SIRT enzymes “turn off” certain genes that promote aging, such as those involved in inflammation,20,21 in fat synthesis and storage,22,23 and in blood sugar management.3,22,23

SIRT enzymes are activated by calorie restriction, the proven means of reliably extending life span in all organisms.2,24 The way calorie restriction activates anti-aging sirtuins is by increasing cellular NAD+.2,25,26"
« Last Edit: October 20, 2014, 09:54:05 am by PeakT »
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program.aspx
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Sam

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Re: Anti-Aging Breakthrough? NAD+ and Berberine Boost Sirutins
« Reply #1 on: October 20, 2014, 08:59:02 am »
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366688/

Quote
Abstract
Berberine (BBR) has recently been shown to improve insulin sensitivity in rodent models of insulin resistance. Although this effect was explained partly through an observed activation of AMP-activated protein kinase (AMPK), the upstream and downstream mediators of this phenotype were not explored. Here, we show that BBR supplementation reverts mitochondrial dysfunction induced by High Fat Diet (HFD) and hyperglycemia in skeletal muscle, in part due to an increase in mitochondrial biogenesis. Furthermore, we observe that the prevention of mitochondrial dysfunction by BBR, the increase in mitochondrial biogenesis, as well as BBR-induced AMPK activation, are blocked in cells in which SIRT1 has been knocked-down. Taken together, these data reveal an important role for SIRT1 and mitochondrial biogenesis in the preventive effects of BBR on diet-induced insulin resistance.
« Last Edit: October 20, 2014, 09:54:13 am by PeakT »

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Re: Anti-Aging Breakthrough? NAD+ and Berberine Boost Sirutins
« Reply #1 on: October 20, 2014, 08:59:02 am »


PeakT

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Re: Anti-Aging Breakthrough? NAD+ and Berberine Boost Sirutins
« Reply #2 on: October 20, 2014, 09:53:56 am »
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366688/

Quote
Abstract
Berberine (BBR) has recently been shown to improve insulin sensitivity in rodent models of insulin resistance. Although this effect was explained partly through an observed activation of AMP-activated protein kinase (AMPK), the upstream and downstream mediators of this phenotype were not explored. Here, we show that BBR supplementation reverts mitochondrial dysfunction induced by High Fat Diet (HFD) and hyperglycemia in skeletal muscle, in part due to an increase in mitochondrial biogenesis. Furthermore, we observe that the prevention of mitochondrial dysfunction by BBR, the increase in mitochondrial biogenesis, as well as BBR-induced AMPK activation, are blocked in cells in which SIRT1 has been knocked-down. Taken together, these data reveal an important role for SIRT1 and mitochondrial biogenesis in the preventive effects of BBR on diet-induced insulin resistance.

Berberine does something similar guys. 

Sam:  Notice I changed the thread title.  Interesting!
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program.aspx
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Sam

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Re: Anti-Aging Breakthrough? NAD+ and Berberine Boost Sirutins
« Reply #3 on: October 20, 2014, 02:44:56 pm »
I think Caffeine may also Peak, but I could be wrong on that.   I think dysfunction in this system is at the root of Metabolic Syndrome and Type 2 Diabetes and low SHBG leading to hormone imbalance and a downward spiral being a big factor in disease progression associated with Western Lifestyle.  Clearly an area that could benefit from more research or at a minimum some straight talk on it from the Surgeon General.

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Re: Anti-Aging Breakthrough? NAD+ and Berberine Boost Sirutins
« Reply #3 on: October 20, 2014, 02:44:56 pm »