Very interesting.. I have been using a good amount of curcumin via turmeric and my liver supplement. Note my last couple blood tests showed low Ferritin.
Clinical studies in humans with high doses (2–12 grams) of curcumin have shown few side-effects, with some subjects reporting mild nausea or diarrhea. More recently, curcumin was found to alter iron metabolism by chelating iron and suppressing the protein hepcidin, potentially causing iron deficiency in susceptible patients.
Great article Sam - thx. You should read the study: it notes dose dependency.http://www.ncbi.nlm.nih.gov/pubmed/18815282
"Against this backdrop of subclinical iron deficiency, curcumin exerted profound 2 effects on systemic iron, inducing a dose-dependent decline in hematocrit, hemoglobin, serum iron, and transferrin saturation, the appearance of microcytic anisocytotic red blood cells, and decreases in spleen and liver iron content."
Again, I think the most sane approach is to eat a well-rounded diet with lots of anti-angiogenic and anti-inflammatory whole foods rather than megadosing one supplement. The piperine that some of the supplement manufacturers use has always made me nervous for example.
I'll update a couple of my articles with this info as well.
The one thing I would add, though, is that curry/turmeric/curcumin has a rich research and epidemiological history and I think it is a "superfood" that should not be thrown out due to megadosing issues...