I used to be a big preg/dhea guy. I have tried Crisler's TD preg, also gone with sublingual and straight up oral preg from Vitacost. The theory is great, and I can definitely attest to all forms of Preg and Dhea having an effect of some sort.
However, the crapshoot that comes with supping a hormone so high up as preg can have very confusing ramifications and I believe a lot of guys start on these when they are also starting TRT, thyroid, and vitamins etc; this is a problem.
For instance, I have low cortisol and adding Preg boosted my Prog and my cortisol, which gave me warmer hands, a clearer mindset, and warmer temps. Then the Preg started raising dhea which raised e1 (not e2 for some reason). I would have increasing ED and other issues. The problem was that I didn't know what the reason was...was it my preg going to prog lowering dht? Was it preg going to e1? Was it elevated prog lowering my e2? Was the increase of thyroid hormones upping shbg? SO MANY FREAKIN POSSIBILITIES!!!!!
All ridiculousness aside, when starting out, I wish I had kept it simple. Thyroid and HC first, see if hc helps, get your dosages right. Add TRT, just T, not HCG, wait a few months, see e2. Then maaaybe address these other areas.
This way you have a simple, adjustable baseline of health to start from and then can easier pinpoint the cause of any issues. We aren't the "norm" when it comes to how our bodies work and utilize hormones and nutrients. So to say "you're low in preg, take preg" is a bit of an oversimplification, especially considering how many other hormones it can convert to, and how that conversion can be different in each of us.