My Trial With Pregnenolone

[Sighalot]

2 days ago i started with pregnenolone to see what change it does, dose is currently 50mg a day, i have not felt any positive effects yet but im hoping for a change,

Prior medication is nebido every 6 week, first and second injection had T levels at 14-15 pmol/L 35 days after injection and it was borderline enough for me, got low shbg so both free and bioavailable was decent.

Due to elevated estradiol im also using arimidex at very low dose since im trying to find out how much i actually need so only dosing when i got clear symptoms, last injection was march 11 and so far taken 1.58mg total and im not sure i will even go over 2mg before next injection april 22.

Regards
Sighalot

[PeakT]

2 days ago i started with pregnenolone to see what change it does, dose is currently 50mg a day, i have not felt any positive effects yet but im hoping for a change,

Prior medication is nebido every 6 week, first and second injection had T levels at 14-15 pmol/L 35 days after injection and it was borderline enough for me, got low shbg so both free and bioavailable was decent.

Due to elevated estradiol im also using arimidex at very low dose since im trying to find out how much i actually need so only dosing when i got clear symptoms, last injection was march 11 and so far taken 1.58mg total and im not sure i will even go over 2mg before next injection april 22.

Regards
Sighalot

Good luck.  You might want to split it up into two doses daily?

[Sighalot]

One reason why i take one dose in the morning, seems to be a "slow" hormone and also seen 2 users say it worked best when taken in the morning.

Pregnenolone is largely converted into two other "youth-associated" protective hormones, progesterone and DHEA. At the age of 30, both men and women produce roughly 30 to 50 mg. of pregnenolone daily. When taken orally, even in the powdered form, it is absorbed fairly well. One dose of approximately 300 mg (the size of an aspirin tablet) keeps acting for about a week, as absorption continues along the intestine, and as it is "recycled" in the body. Part of this long lasting effect is because it improves the body's ability to produce its own pregnenolone. It tends to improve function of the thyroid and other glands, and this "normalizing" effect on the other glands helps to account for its wide range of beneficial effects.
http://raypeat.com/articles/articles/three-hormones.shtml

[PeakT]

One reason why i take one dose in the morning, seems to be a "slow" hormone and also seen 2 users say it worked best when taken in the morning.

Pregnenolone is largely converted into two other "youth-associated" protective hormones, progesterone and DHEA. At the age of 30, both men and women produce roughly 30 to 50 mg. of pregnenolone daily. When taken orally, even in the powdered form, it is absorbed fairly well. One dose of approximately 300 mg (the size of an aspirin tablet) keeps acting for about a week, as absorption continues along the intestine, and as it is "recycled" in the body. Part of this long lasting effect is because it improves the body's ability to produce its own pregnenolone. It tends to improve function of the thyroid and other glands, and this "normalizing" effect on the other glands helps to account for its wide range of beneficial effects.
http://raypeat.com/articles/articles/three-hormones.shtml

So are you a follower of Ray Peat or just happened to come across one of his articles?

[Sighalot]

Came across it when i was searching what doses is used with pregnenolone.

[PeakT]

Came across it when i was searching what doses is used with pregnenolone.

Really int'g article from Ray Sahelian.  His dosage is smaller and he has really played with this a lot it sounds like:

http://www.life-enhancement.com/magazine/article/95-exclusive-interview-with-ray-sahelian-md-the-promise-of-pregnenolone

[tomahawk]

thanks for posting this! please give us an update in a few weeks please?

couple of questions, if you take Pregnenolone, does your own "production" suppress or shut down?
guessing... would the body pick up exogenous Preg and therefore Cholesterol levels would raise?

[tomahawk]

from Dr Lam, this is actually for women, but maybe it's similar for men?

"Some with Adrenal Fatigue find pregnenolone replacement improves their energy, vision, memory, clarity of thinking, well being, and often sexual enjoyment or libido. Some women report lessening of hot flashes or premenstrual symptoms and this is likely due to the rise of progesterone (the biological daughter of pregnenolone) reduction in estrogen dominance. Others, however, may find pregnenolone worsen existing fatigue and may even trigger adrenal crashes. Such paradoxical reactions are common. The more advanced the adrenal weakness, the more likely such experiences are common."

[PeakT]

from Dr Lam, this is actually for women, but maybe it's similar for men?

"Some with Adrenal Fatigue find pregnenolone replacement improves their energy, vision, memory, clarity of thinking, well being, and often sexual enjoyment or libido. Some women report lessening of hot flashes or premenstrual symptoms and this is likely due to the rise of progesterone (the biological daughter of pregnenolone) reduction in estrogen dominance. Others, however, may find pregnenolone worsen existing fatigue and may even trigger adrenal crashes. Such paradoxical reactions are common. The more advanced the adrenal weakness, the more likely such experiences are common."

Yes, although I think a lot of the problems are because people take too much of most of the these hormones. I see that on the melatonin side all the time.

[Sighalot]

thanks for posting this! please give us an update in a few weeks please?

The idea was to write every now and then how it works and side effects.

couple of questions, if you take Pregnenolone, does your own "production" suppress or shut down?
guessing... would the body pick up exogenous Preg and therefore Cholesterol levels would raise?

Im using exogenous testosterone and it affects the conversion of cholesterol to pregnenolone, i have planned to visit the gp next month to talk about some blood tests so can include cholesterol.

Really int'g article from Ray Sahelian.  His dosage is smaller and he has really played with this a lot it sounds like:

Half capsule under the tongue will be tested.

Yes, although I think a lot of the problems are because people take too much of most of the these hormones. I see that on the melatonin side all the time.

I saw it alot when i read up on dhea, doses up to 400mg was recommended and used...wonder if i would even survive a dose like that considering how much effect i had with 30mg :O

[PeakT]

Did you see that other thread i posted?  No one even know what a physiological level is.

[Sighalot]

.......feels like estradiol is on the rise, will take 1/3 of a pill today too see what happens but its the third dosing since march 31st so its a slight increase but if its pregnenolone i can not say for sure.

Did you see that other thread i posted?  No one even know what a physiological level is.

Thread about adrenal fatigue?

Talked too a women in my country which had pregnenolone prescribed, dose was 100mg for 3 months then lower too 50mg.

[PeakT]

.......feels like estradiol is on the rise, will take 1/3 of a pill today too see what happens but its the third dosing since march 31st so its a slight increase but if its pregnenolone i can not say for sure.

Did you see that other thread i posted?  No one even know what a physiological level is.

Thread about adrenal fatigue?

Talked too a women in my country which had pregnenolone prescribed, dose was 100mg for 3 months then lower too 50mg.

Okay, I wrote a post for this, but I think I forgot to hit send!  Here is the article - I think you'll find it interesting.  I'm gonna make a separate thread now and make sure I hit send.

[Sighalot]

.......feels like estradiol is on the rise, will take 1/3 of a pill today too see what happens but its the third dosing since march 31st so its a slight increase but if its pregnenolone i can not say for sure.

Estradiol it was alright, took 1/3 arimidex yeasterday, when i went to sleep i opened up a ball of tinfoil and dipped my finger in some white powder and rubbed on my gum hopping i got the right amount of melatonin and went to bed, melatonin doses lower then 1mg are not available over here.
Feel asleep in a matter of minutes, sleeped through the night woke up after 6 hours for a visit to the toilet, then i went back to bed half asleep half awake feeling very comfortable for 1½ hours then i went up 1 minute before my alarm went off.
Walked out in the kitchen, feeling the sun on my face knowing summer is just around the corner whistling christmas songs with a quite ok morning wood.
Took my bike out for a ride and feeling better then usual, i even noticed the cars before running into them lol but i wonder if 50mg may be on the high side since it noticeably rises estradiol.

May buy me a scale that can measure down to 0.01gram so i can split a capsule into smaller doses.

[VinnAY]

I've been using the Pharm grade I think 30mg for about a month, one in the morning without anything noticeable (along with 10mg DHEA). Something I did do today, different, was do both of those sublingual holding the capsules under my tongue for 5-10 minutes. Didn't taste bad, but need to do that steady to see if that works better for me.