This is from the site Ray Peat Forum. Though this isn't an abstract or direct quote from Ray Peat, the poster states that he has used high doses of preg and states that RP also used high doses for several years to reverse long standing health problems related to poor metabolic function, since RP is an endocrine physiologist who uses himself as a test subject.
I truly feel better, mood wise, than I have in many years. Between Testopel and preg, my libido is closer to what it was in my 20s and there has been a small improvement in erectile function though I've got a way to go. I'm certainly not advocating my approach to anyone else, but HPTA axis malfunction is an established fact in bipolar illness and poor mitochondrial function is also implicated. The aforementioned problems need to be dealt with and preg, IMO, is the perfect pro hormone to begin my physical and psychiatric restoration. I'll search RP Forum for a direct quote from Ray Peat stating that pregnenolone, alone, can restore function and balance to the entire endocrine system.
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Pregnenolone likely effective for schizophrenia
Postby haidut » Mon Feb 17, 2014 2:30 am
I have been following this for some time now. The pharma industry is quickly running out of options for managing drug-resistant schizophrenia so it is turning to therapies from the beginning of the 20th century. Either way, if this makes it through the clinical trials it would be a huge win for Ray's ideas but bad news for us b/c I can guarantee you that pregnenolone's status as a dietary supplement will end the moment FDA realizes it works for a variety of "untreatable" brain conditions including all types of dementia (hint: AD) and psychiatric diseases.http://www.sciencedirect.com/science/ar
The human studies used pregnenolone as adjunctive therapy and saw very positive results with the low dose of 50mg/day. The last study is a rodent study and used only pregnenolone, and it completely stopped the diseases. The human dosage equivalent from that study is 400mg-500mg per day. Though high, it is considered quite safe. Ray has taken 1g for extended period of time with no complaints and I have gone even higher with no side effects. The study I posted on pregnenolone's stimulatory effect on the thyroid used a human dose equivalent of 2.5g per day.