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Are you currently using DHEA, Pregnenalone, both or none of the above?

I am currently using DHEA.
15 (42.9%)
I am currently using pregnenalone
7 (20%)
I am currently using both DHEA and pregnenalone
3 (8.6%)
I am currently not using either DHEA or pregnenalone.
10 (28.6%)

Total Members Voted: 35

Author Topic: POLL: DHEA and Pregnenalone Use  (Read 22618 times)

PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #30 on: August 06, 2015, 03:36:03 am »
Thrid week on pregnenolone.  Started at 500mg daily, mixed in some olive oil, (Came to that dose per my reading and feedback on Ray Peat Forum, and as I've said, I'm a mad scientist!).  It definitely broke my long standing depression after three weeks.  Also has raised my libido but only slight improvement in erectile function.  My wife and I were making out.(A perfectly good term, lol)and I did get a good, strong erection but I didn't make it to the finals...sigh.  We had a good time and I still left her with a smile on her face.  No further comments. 8)

I was thinking about adding transdermal DHEA, 10 to 20mg in order to avoid excessive E2 conversion, which happened when I did 25mg oral a couple of years ago.  But DHEA, as I've previously written, had a most positive effect on libido and erectile function, as well as mood.

500 mg?!?  Wow.  Can you show me the links that advise that?

We just had a guy on here that jacked up his progesterone supraphysiological, which slammed his DHT down and he seemed stuck in that state.
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Tropicaldaze

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Re: POLL: DHEA and Pregnenalone Use
« Reply #31 on: August 08, 2015, 03:52:05 pm »
Peak,

This is from the site Ray Peat Forum.  Though this isn't an abstract or direct quote from Ray Peat, the poster states that he has used high doses of preg and states that RP also used high doses for several years to reverse long standing health problems related to poor metabolic function, since RP is an endocrine physiologist who uses himself as a test subject.

I truly feel better, mood wise, than I have in many years.  Between Testopel and preg, my libido is closer to what it was in my 20s and there has been a small improvement in erectile function though I've got a way to go.  I'm certainly not advocating my approach to anyone else, but HPTA axis malfunction is an established fact in bipolar illness and poor mitochondrial function is also implicated. The aforementioned problems need to be dealt with and preg, IMO, is the perfect pro hormone to begin my physical and psychiatric restoration.  I'll search RP Forum for a direct quote from Ray Peat stating that pregnenolone, alone, can restore function and balance to the entire endocrine system.


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Pregnenolone likely effective for schizophrenia

 Postby haidut Mon Feb 17, 2014 2:30 am

I have been following this for some time now. The pharma industry is quickly running out of options for managing drug-resistant schizophrenia so it is turning to therapies from the beginning of the 20th century. Either way, if this makes it through the clinical trials it would be a huge win for Ray's ideas but bad news for us b/c I can guarantee you that pregnenolone's status as a dietary supplement will end the moment FDA realizes it works for a variety of "untreatable" brain conditions including all types of dementia (hint: AD) and psychiatric diseases.

http://www.sciencedirect.com/science/ar ... 0786X?np=y
http://www.ncbi.nlm.nih.gov/pubmed/24496044
http://www.ncbi.nlm.nih.gov/pubmed/23240026

The human studies used pregnenolone as adjunctive therapy and saw very positive results with the low dose of 50mg/day. The last study is a rodent study and used only pregnenolone, and it completely stopped the diseases. The human dosage equivalent from that study is 400mg-500mg per day. Though high, it is considered quite safe. Ray has taken 1g for extended period of time with no complaints and I have gone even higher with no side effects. The study I posted on pregnenolone's stimulatory effect on the thyroid used a human dose equivalent of 2.5g per day.
65 y.o., 5'5", 138lbs.
Complex medical history: treatment resistant ultra rapid cycling bipolar illness, history of thyroid and adrenal problems. ED/libido problems since 2010.  Restoring my physical health has been, and remains, a daunting challenge.

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Re: POLL: DHEA and Pregnenalone Use
« Reply #31 on: August 08, 2015, 03:52:05 pm »


PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #32 on: August 08, 2015, 07:17:35 pm »
Just started 50mg of pregnenolone oral pill. Trying to raise progesterone which was at 0.4. I am tapering off clonazepam and want to get my progesterone up before further tapering.  Hcg did not raise my progesterone at all! Benzo tapering sucks!! Any advice on above material welcomed!!

I'd start lower and I'd measure yourself first including progesterone.
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If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #33 on: October 15, 2015, 12:47:56 pm »
Bump...

Trying to get new members to vote.
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Re: POLL: DHEA and Pregnenalone Use
« Reply #33 on: October 15, 2015, 12:47:56 pm »


PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #34 on: January 19, 2016, 05:25:26 pm »
Bump...
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Torrential

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Re: POLL: DHEA and Pregnenalone Use
« Reply #35 on: January 20, 2016, 02:31:47 pm »
500mg of preg is more than I've even heard of anyone using. However, oral is poorly adsorbed so maybe the net effective dose is more reasonable.

I take DHEA, 25mg oral morning and evening. I started with one pill, got a nice bump in DHEA-S, and added a second pill at my dr's suggestion. FWIW, I use preg only rarely these days and only sublingual. The Source Naturals brand has worked very well for me in the 10mg and 25mg dosages.
« Last Edit: January 20, 2016, 02:34:00 pm by Torrential »
Age 54, 6'0", 200#
Dec '15:  T-total 901, T-free 159.1, E2 17, SHBG 28
Mar '16:  T-total 801, T-free 208.8, E2 18, SHBG 14
Jun '16:  T-total 678, T-free 31.9 (above range); E2 9; working to increase SHBG
Sep '16:  T-total 1075, T-free 31.4, e2 50 (wow)
Jan-Mar '16:  T-cyp 120mg per week @34mg EOD; 300IU HCG EOD, 0.25 Anastrozole E3D
Apr '16: T-cyp 105mg per week @30mg EOD; 300IU HCG EOD; 0.25mg Anastrozole E3D
Jun '16:  Low E2: dropping Anastrozole, reducing HCG to 250IU EOD.  T-Cyp 16ml/32mg EOD
Supps:  SloNiacin, aspirin, Vit. C., aged garlic,

PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #36 on: January 20, 2016, 03:36:03 pm »
500mg of preg is more than I've even heard of anyone using. However, oral is poorly adsorbed so maybe the net effective dose is more reasonable.

I take DHEA, 25mg oral morning and evening. I started with one pill, got a nice bump in DHEA-S, and added a second pill at my dr's suggestion. FWIW, I use preg only rarely these days and only sublingual. The Source Naturals brand has worked very well for me in the 10mg and 25mg dosages.

Why did you stop using pregnenalone?

And, yes, I agree that 500 mg is way too much.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
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If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Sighalot

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Re: POLL: DHEA and Pregnenalone Use
« Reply #37 on: January 20, 2016, 04:24:47 pm »
500mg of preg is more than I've even heard of anyone using.
Ray Peat have tried 1500mg.
Quote
However, oral is poorly adsorbed so maybe the net effective dose is more reasonable.
Thats the reason why i went over to sublingual, i needed ~200mg to feel a difference but with sublingual it was enough with 6mg and even that may have been to much.


PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #38 on: January 20, 2016, 05:01:19 pm »
500mg of preg is more than I've even heard of anyone using.
Ray Peat have tried 1500mg.
Quote
However, oral is poorly adsorbed so maybe the net effective dose is more reasonable.
Thats the reason why i went over to sublingual, i needed ~200mg to feel a difference but with sublingual it was enough with 6mg and even that may have been to much.

Okay, but we have now had two guys go supraphysiological in progesterone with about a fifth of the dosage that you took.  And they did not do well by the way with the high progesterone as you might expect. 
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Joe Sixpack

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Re: POLL: DHEA and Pregnenalone Use
« Reply #39 on: January 25, 2016, 01:12:40 am »
I take both
Please include a comment as to

a) how much you are taking
    25 MG DHEA Oral/day.  12MG Preg Sublingual drops/day

c) benefits - None Noted

d) side effects - None Noted

e) how long you have been taking it:  4 months

g) did you get a lab read before you started? 
Preg was 32 at start,
DHEA 93 at start. 
Had a follow up lab of DHEA at 3 months, when it was measured at 129
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #40 on: January 25, 2016, 03:40:49 am »
I'm assuming you meant DHEAS and I'm surprised I didn't bump you up higher
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Joe Sixpack

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Re: POLL: DHEA and Pregnenalone Use
« Reply #41 on: January 25, 2016, 04:11:48 am »
I'm assuming you meant DHEAS and I'm surprised I didn't bump you up higher
Yes I did mean DHEA-S.  Lazy typing.  I am disappointed by the lack of progress on that as well.   I'm thinking I want to jack it up to 50MG.  Or change to sublingual DHEA.  The sublingual pregnenalone worked pretty well for me. 
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #42 on: January 25, 2016, 04:39:37 am »
I'm assuming you meant DHEAS and I'm surprised I didn't bump you up higher
Yes I did mean DHEA-S.  Lazy typing.  I am disappointed by the lack of progress on that as well.   I'm thinking I want to jack it up to 50MG.  Or change to sublingual DHEA.  The sublingual pregnenalone worked pretty well for me.

25 mg was supposed to triple min roughly.  I am going to do some measurements here and so we will see what happens.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Joe Sixpack

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Re: POLL: DHEA and Pregnenalone Use
« Reply #43 on: January 26, 2016, 01:26:19 am »
I'm assuming you meant DHEAS and I'm surprised I didn't bump you up higher
Yes I did mean DHEA-S.  Lazy typing.  I am disappointed by the lack of progress on that as well.   I'm thinking I want to jack it up to 50MG.  Or change to sublingual DHEA.  The sublingual pregnenalone worked pretty well for me.

25 mg was supposed to triple min roughly.  I am going to do some measurements here and so we will see what happens.

Let us know what you find out.  25 MG didn't do much for me.  It's possible that my brand of DHEA is just not any good.  I am using Country Life brand. 
Age: 55, Ht: 5'08", Wt: 155 lbs
Protocol: 25 mg T Cyp + 25 IU HCG M,W,F + 2 clicks T Cream + 15mg DHEA + 15mg Pregnenalone daily.
12/2018 test results: TT: 1054 ng/dL (264-916), FT: 17.2 pg/mL (7.2-24), E2: 21.6 pg/mL sensitive (8.0-35.0)

PeakT

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Re: POLL: DHEA and Pregnenalone Use
« Reply #44 on: January 26, 2016, 03:05:12 am »

Let us know what you find out.  25 MG didn't do much for me.  It's possible that my brand of DHEA is just not any good.  I am using Country Life brand.

Dr. Saya said that that is a big advantage that you get with compounded DHEA/preg.  He said the brands just don't work that well often (for reasons unknown).
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
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And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: POLL: DHEA and Pregnenalone Use
« Reply #44 on: January 26, 2016, 03:05:12 am »