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Author Topic: Progesterone - What Dosage Should I Use?  (Read 9943 times)

27lowt

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Progesterone - What Dosage Should I Use?
« on: July 22, 2015, 03:59:35 pm »
I went to my dr yesterday and asked my high estrogen levels (266.9) he said no big deal. I read an article here where u can take progesterone to help lower estrogen levels. My question is 10 mg enough or is it 20 mg? Where do you buy progesterone? Any patrticular brand? Recommedations?
« Last Edit: July 22, 2015, 04:30:52 pm by PeakT »

dfs

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Re: Progesterone - What Dosage Should I Use?
« Reply #1 on: July 22, 2015, 04:09:38 pm »
« Last Edit: July 22, 2015, 04:32:41 pm by PeakT »

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Re: Progesterone - What Dosage Should I Use?
« Reply #1 on: July 22, 2015, 04:09:38 pm »


PeakT

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Re: Progesterone - What Dosage Should I Use?
« Reply #2 on: July 22, 2015, 04:30:28 pm »
I went to my dr yesterday and asked my high estrogen levels (266.9) he said no big deal. I read an article here where u can take progesterone to help lower estrogen levels. My question is 10 mg enough or is it 20 mg? Where do you buy progesterone? Any patrticular brand? Recommedations?

Well, I don't necessarily recommend progesterone.  Here is why I'm cautious right now:

1.  LEF avoids prescribing it.

2.  The creams can accumulate in tissues in some men per Mercola.

3.  It has quite a few "anti-male qualities per Dr. Crisler.

So, if I had low progesterone, I'd probably try taking some pregnenalone and seeing if I could boost it that way.  JustAskin had success with that recently.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

PeakT

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Re: Progesterone - What Dosage Should I Use?
« Reply #3 on: July 22, 2015, 04:32:15 pm »
I found this article yesterday. I did not know that progesterone would lower estrogen.
http://chestsculpting.com/how-i-boosted-testosterone-and-reduced-estrogen-with-a-regimen-of-progesterone-pregnenolone-dhea-and-d-aspartic-acid/


fyi:  The most recent study on D-Aspartic Acid shows that it actually LOWERED testosterone.  There is also evidence that it can increase estradiol  So why it is in this combo I don't understand.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: Progesterone - What Dosage Should I Use?
« Reply #3 on: July 22, 2015, 04:32:15 pm »


27lowt

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Re: Progesterone - What Dosage Should I Use?
« Reply #4 on: July 22, 2015, 05:45:53 pm »
I read that same article DFS. peak t what do u recommend then if u dont rexommend this?

PeakT

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Re: Progesterone - What Dosage Should I Use?
« Reply #5 on: July 22, 2015, 09:00:53 pm »
I read that same article DFS. peak t what do u recommend then if u dont rexommend this?

Well, wait.  I have a starting question for you:  have you pulled your progesterone?  Imo you don't even want to think about using it unless you are on the low side and, even then, you can make a case against it per the above.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Cataceous

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Re: Progesterone - What Dosage Should I Use?
« Reply #6 on: July 23, 2015, 01:09:32 am »
I'm also interested in progesterone. I did have the saliva test and it came back at the bottom of the scale, 12 pg/mL (12-100). The points against supplementing seem pretty subjective, as admittedly do many in favor. However, if it does work against E2 and DHT then it could be useful.

I'd have to search for it, but in another thread a member claimed that oral supplementation wouldn't lead to tissue buildup. Does anyone know of other supporting references?
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 60, Ht: 5'10", Wt: 154 lbs
Protocol: 3.2 mg TE subQ qd, 2.4 mg TP subQ qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

PeakT

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Re: Progesterone - What Dosage Should I Use?
« Reply #7 on: July 23, 2015, 01:27:58 am »
I'm also interested in progesterone. I did have the saliva test and it came back at the bottom of the scale, 12 pg/mL (12-100). The points against supplementing seem pretty subjective, as admittedly do many in favor. However, if it does work against E2 and DHT then it could be useful.

I'd have to search for it, but in another thread a member claimed that oral supplementation wouldn't lead to tissue buildup. Does anyone know of other supporting references?

There are virtually no studies in males - that's the problem.  Here is another discussion of it that I found:

http://www.holistichealthtools.com/10-things-kokoro.pdf

This article is for women, but notice:

"Progesterone cream utilizes fatty and cellular tissue as 'reservoirs' for storing progesterone,
providing a more sustained level of progesterone exposure. This 'storage' was validated by
Chang et al in their 1995 study utilising transdermal progesterone on women with breast cancer.
But an accumulation of progesterone in the body can lead to suppression of natural hormone
production and can promote abnormal actions in the body. "
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Cataceous

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Re: Progesterone - What Dosage Should I Use?
« Reply #8 on: July 23, 2015, 01:44:31 am »

There are virtually no studies in males - that's the problem.  Here is another discussion of it that I found:

http://www.holistichealthtools.com/10-things-kokoro.pdf

This article is for women, but notice:

"Progesterone cream utilizes fatty and cellular tissue as 'reservoirs' for storing progesterone,
providing a more sustained level of progesterone exposure. This 'storage' was validated by
Chang et al in their 1995 study utilising transdermal progesterone on women with breast cancer.
But an accumulation of progesterone in the body can lead to suppression of natural hormone
production and can promote abnormal actions in the body. "

Just yesterday I read the page cited above by dfs. It must be one of the top Google hits. If that guy is topically applying 60 mg progesterone/day is he likely to have a very large buildup in the 'reservoirs'?
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 60, Ht: 5'10", Wt: 154 lbs
Protocol: 3.2 mg TE subQ qd, 2.4 mg TP subQ qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

PeakT

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Re: Progesterone - What Dosage Should I Use?
« Reply #9 on: July 23, 2015, 02:11:37 am »

There are virtually no studies in males - that's the problem.  Here is another discussion of it that I found:

http://www.holistichealthtools.com/10-things-kokoro.pdf

This article is for women, but notice:

"Progesterone cream utilizes fatty and cellular tissue as 'reservoirs' for storing progesterone,
providing a more sustained level of progesterone exposure. This 'storage' was validated by
Chang et al in their 1995 study utilising transdermal progesterone on women with breast cancer.
But an accumulation of progesterone in the body can lead to suppression of natural hormone
production and can promote abnormal actions in the body. "

Just yesterday I read the page cited above by dfs. It must be one of the top Google hits. If that guy is topically applying 60 mg progesterone/day is he likely to have a very large buildup in the 'reservoirs'?

Not sure.  Here is what one man did on our forum though:

http://www.peaktestosterone.com/forum/index.php?topic=2270.0  (See Phatphish's comments.)
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Cataceous

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Re: Progesterone - What Dosage Should I Use?
« Reply #10 on: July 23, 2015, 02:28:21 am »
Here's the post by explorer saying that he prefers oral administration.

Quote
I like oral progesterone better. Such as prometrium or Progest-E (this one you have to keep in the fridge).

It's easier to stop taking progesterone if you take it orally. If you take it topically, it stays in your fat tissue, and then it gradually drips into the bloodstream. Some people who used progesterone topically for this reason had it released from their fat tissues to their bloostream for 6 months after stopping application of the cream, because they didn't like its effects. So they had to suffer its effects for 6 more months! While if it's oral, you just stop taking it and in a few days or weeks it's normalized.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 60, Ht: 5'10", Wt: 154 lbs
Protocol: 3.2 mg TE subQ qd, 2.4 mg TP subQ qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

PeakT

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Re: Progesterone - What Dosage Should I Use?
« Reply #11 on: July 23, 2015, 01:50:48 pm »
Here's the post by explorer saying that he prefers oral administration.

Quote
I like oral progesterone better. Such as prometrium or Progest-E (this one you have to keep in the fridge).

It's easier to stop taking progesterone if you take it orally. If you take it topically, it stays in your fat tissue, and then it gradually drips into the bloodstream. Some people who used progesterone topically for this reason had it released from their fat tissues to their bloostream for 6 months after stopping application of the cream, because they didn't like its effects. So they had to suffer its effects for 6 more months! While if it's oral, you just stop taking it and in a few days or weeks it's normalized.

Great point.  For those unfamiliar, Ray Peat created a product called Progest-E that is - and I know little about it - an oral progesterone formulation.

Again, though, one may want to try some pregnenalone, especially if you are on the low side, and see if that will backfill the progesterone.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Cataceous

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Re: Progesterone - What Dosage Should I Use?
« Reply #12 on: July 23, 2015, 02:57:14 pm »
Again, though, one may want to try some pregnenalone, especially if you are on the low side, and see if that will backfill the progesterone.

What is low for pregnenalone? I tested at 33 ng/dL. Rather than a range it just says <151 for adults.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 60, Ht: 5'10", Wt: 154 lbs
Protocol: 3.2 mg TE subQ qd, 2.4 mg TP subQ qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

PeakT

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Re: Progesterone - What Dosage Should I Use?
« Reply #13 on: July 23, 2015, 05:06:38 pm »
Again, though, one may want to try some pregnenalone, especially if you are on the low side, and see if that will backfill the progesterone.

What is low for pregnenalone? I tested at 33 ng/dL. Rather than a range it just says <151 for adults.

Yeah, I meant low on the lab range.
THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Cataceous

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Re: Progesterone - What Dosage Should I Use?
« Reply #14 on: July 27, 2015, 06:30:40 pm »
On the other hand, there seems to be evidence that oral administration of progesterone is not very effective. From here:

Quote
Use a natural progesterone skin cream, not drops or pills. Progesterone is poorly absorbed when taken orally, being broken down by the liver and gut and excreted instead of being bio-available for use in the body. 95% of progesterone taken orally as tablets or drops is lost. (23) Progesterone is well absorbed transdermally (through the skin), and using it as a cream on the skin is the most effective method to take it.
...
23. Parr RA, Davis IF, Miles MA, Squires TJ. Liver blood flow and metabolic clearance rate of progesterone in sheep. Res Vet Sci. 1993 Nov;55(3):311-6. Article

Referring to the OP's question, the article says:

Quote
  • Men should use 10-100mg per day. This is suitable to treat symptoms of low progesterone, symptoms of low testosterone, or more commonly, symptoms of estrogen dominance caused by xenoestrogens. Vary the dose depending on the severity of the symptoms. The amount of progesterone to use is not dependent on your weight, size, height or age, but on your symptoms.
  • If you are treating symptoms of estrogen dominance caused by xenoestrogens, remember to start with a sufficiently high dose, and persevere if the symptoms of estrogen dominance appear or get worse during the first few days.
  • Maintenance dose. After your symptoms of estrogen overload have passed the amount of progesterone cream you use should be reduced very slowly over at least a few weeks. After a few months you will find the optimum dose that prevents your adverse symptoms returning and on which you feel good. Your maintenance will depend on your particular situation, symptoms, and level of xenoestrogen build-up.
I am not a medical doctor; any suggestions are meant to be discussed with your doctor.
Age: 60, Ht: 5'10", Wt: 154 lbs
Protocol: 3.2 mg TE subQ qd, 2.4 mg TP subQ qd, 20 mcg GnRH subQ 5.25x/d, 6.25 mg DHEA bid, 12.5 mg enclomiphene qod
Approximate levels (peak): TT: 700 ng/dL, E2: 30 pg/mL, DHEA-S: 300 ug/dL, SHBG: 30 nMol/L

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Re: Progesterone - What Dosage Should I Use?
« Reply #14 on: July 27, 2015, 06:30:40 pm »