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Author Topic: Can Intestinal Issues Take Out the Liver (and SHBG)?  (Read 12176 times)

PeakT

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #15 on: June 20, 2015, 05:53:13 am »
Interesting , i have tested for candida and it turned out negative, but i still suspect that i have gut flora imbalance and not enough good bacteria. Here is one study http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481143/ that shows a link between NAFLD and the gut microbiome.

Its possible that a leaky gut or absence of certain types of good bacteria leads to overburdening of the liver and impairing its detoxification pathways. As i have mentioned in other low SHBG threads i have a very congested liver with many gallstones coming out when flushing, so i think the congestion could possibly be caused from leaky gut. I have recently started culturing kefir and kombucha as to replenish my gut flora and possibly heal leaky gut, because i read that they are much more potent than buying probiotic supplements. I will report if i see any positive results. Also soon i plan to check my SHBG level to see whether it has improved from all the liver flushing that i have done in the last year.

Yeah, imo that is the huge advantage of plant-based eating.  And I don't mean vegan - I just mean where you are getting about 90% of your calories from plants (that aren't refined carbs!).  My gut health is fantastic - it's one of my best body parts - and I really think it's have a respectable amount of fiber, lower heme iron levels, lots of anti-inflammatories and a solid gut flora.  As I keep preaching, we simply do not have the intestines of carnivore and shoving a boatload of fatty stuff down with a few veges throw in just doesn't match our physiology imo.

By the way, guess where most of our serotonin is made?  The gut.  This is why the gut is called by some "The Second Brain."

http://www.caltech.edu/news/microbes-help-produce-serotonin-gut-46495

So if you hammer the gut and your gut flora with a slow moving mass of decaying fat and meat, things just don't go well. 

So I see guys trying to throw in a few probiotics or prebiotics, but if throwing it into the middle of a decaying carcas in their gut, I don't see it doing that much good.  (And I'm not saying that's you btw...)

My two cents...

Oops.  One of the guys reminded me that it won't cross the BBB (blood brain barrier).
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xrayguy

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #16 on: June 20, 2015, 12:01:40 pm »
In my experience, I definitely think that a balanced gut can lead to much better health overall and a better sense of well-being.

I had a very upset stomach for months, I was nauseated every morning and even dry heaving a good portion of the time.  My guts had been thrown totally out of whack due to medications I was taking. It was awful. Someone suggested a probiotic  so I tried a couple, and they both made me worse. They were both fairly expensive probiotics from the grocery store.

I then went to a health food store and told them about how the probiotics made me feel worse. They told me that it was most likely because the probiotic was not enteric coated, and that most of the bacteria was being killed in my stomach. This caused a bunch of dead bacteria to go through my system, making me feel more sick.

They gave me a probiotic in an enteric coated capsule. I had absolutely no negative side effects from it at all.  Within a couple of days, 90% of the GI  problems I was having completely disappeared. I continued on the probiotic every day for a couple of months, and now my gut is virtually completely healed. I have no doubt that it was the probiotic that healed me.  You need to get one that is enteric coated however.
Age 48, 5'10" 185lbs, from Canada

Symptoms: Anxiety, abdominal bloating/cramps/tenderness, fatigue, weakness, insomnia.

Rx treatment:
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E2 19 pg/ml (<54)
SHBG 0.23 (0.20-1.00)
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TSH 4.63 mU/L (0.2-4.0)
Free T3: 6.2 pmol/L (3.5-6.5)
Free T4: 16.2 pmol/L (9.0-23.0)
Cortisol AM 279 nmol/L (120-620)
Cortisol PM 166 nmol/L (85-460)

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T (300-1100ng/dl): 579>507>182>300>369>234
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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #16 on: June 20, 2015, 12:01:40 pm »


hardrlz

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #17 on: June 20, 2015, 01:44:32 pm »
Whats more interesting is how all this possible liver dysfunction results in low output of SHBG. Its frustrating that there isnt much research and doctors have no clue about this situation. I am not familiar with the actual mechanisms of hormones production in the liver, but i guess if the organ is overburdened with toxins some of its functions are impaired. A very uneducated guess of mine is that the gallstones in the liver block the site where SHBG is produced for example.

PeakT

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #18 on: June 20, 2015, 03:51:53 pm »
Whats more interesting is how all this possible liver dysfunction results in low output of SHBG. Its frustrating that there isnt much research and doctors have no clue about this situation. I am not familiar with the actual mechanisms of hormones production in the liver, but i guess if the organ is overburdened with toxins some of its functions are impaired. A very uneducated guess of mine is that the gallstones in the liver block the site where SHBG is produced for example.

Actually, there has been quite a bit of research on this.  What happens is that, if you eat an overly high fat diet or too many refined carbs or put on weight, your liver and muscle cells get stuffed full of "fat," i.e. intracellular myolipids.  These begin to interfere with cellular metabolism and one has the beginnings of fatty liver.  Research has shown that low SHBG in the liver is a great early sign of this liver dysfunction and is very predictive of future diabetes:

Sam actually posted this many moons ago:

http://www.peaktestosterone.com/forum/index.php?topic=2687.0
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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #18 on: June 20, 2015, 03:51:53 pm »


hardrlz

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #19 on: June 20, 2015, 05:49:03 pm »
Does the type of fat matter, like if you eat lots of healthy fats can you still get fatty liver ? I was tested with an ultrasound for NAFLD, but the doctor told me i dont have it, so in my case its something else that impairs my liver function (my liver enzymes are fine too).

Here is one study linking low cortisol with low SHBG  - http://www.nature.com/ijo/journal/v24/n2s/pdf/0801281a.pdf?origin=publication_detail , indicating possible connection between adrenal fatigue and low SHBG.

explorer

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #20 on: June 20, 2015, 05:52:18 pm »
Does the type of fat matter, like if you eat lots of healthy fats can you still get fatty liver ?

Yes, according to many recent studies saturated fats tend to cure it and polyunsaturated fats damage it. Excess iron is another cause.

So at least in this case, the so-called "healthy fats" are the bad fats and the "bad fats" are the good fats.
« Last Edit: June 20, 2015, 05:54:30 pm by explorer »

Sam

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #21 on: June 20, 2015, 09:51:15 pm »
Does the type of fat matter, like if you eat lots of healthy fats can you still get fatty liver ? I was tested with an ultrasound for NAFLD, but the doctor told me i dont have it, so in my case its something else that impairs my liver function (my liver enzymes are fine too).

Here is one study linking low cortisol with low SHBG  - http://www.nature.com/ijo/journal/v24/n2s/pdf/0801281a.pdf?origin=publication_detail , indicating possible connection between adrenal fatigue and low SHBG.

That's a fantastic study and find.  Thanks for posting.  I'm sharing that with my doc.

hardrlz

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #22 on: June 20, 2015, 10:26:07 pm »
No problem :) Let us know what are his thoughts on it as well.

PeakT

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #23 on: June 21, 2015, 01:37:58 am »
Does the type of fat matter, like if you eat lots of healthy fats can you still get fatty liver ? I was tested with an ultrasound for NAFLD, but the doctor told me i dont have it, so in my case its something else that impairs my liver function (my liver enzymes are fine too).

Here is one study linking low cortisol with low SHBG  - http://www.nature.com/ijo/journal/v24/n2s/pdf/0801281a.pdf?origin=publication_detail , indicating possible connection between adrenal fatigue and low SHBG.

Great study btw - much appreciated.

Well, low carb is almost always high fat and high fat is never just omega-3's of course - you'll have an abundance of saturated, mono and polyunsaturated fats as well.  So what happens, according to my understanding, is that you will end up insulin resistant.  In fact, meat actually has a fairly high dietary insulin rating because of this.

Now a low carber will argue that that insulin resistance does not matter that much because they are not eating carbs.  Well, that is kind of true.  The typical guy - and again this is based on what I have seen so research it yourself if you are int'd - on low carb will have a slightly high fasting morning blood sugar.  Now his daytime sugar may not be that bad and his post-meal sugar may not be that bad.

However, that is not always true and some low carbers will have elevated post-meal glucose believe it or not and, as I have mentioned, a good % will have high LDL-P as well, which has a good chance of taking out their arteries imo.  But that's another story.

But let's say you do well on a low carb diet and you have slightly elevated morning blood sugar but do well during the day.  Is that good or bad?  Well, I have seen this debated in a few places and I don't think anyone has the answer.  LEF wants your fasting glucose below 85, so they would not be happy.  But I have seen other say it's not that big of a deal as long as your A1C is good, post-meal glucose, etc.

Imo:  measure post-meal glucose and A1C and fasting glucose in the morning to get a nice snapshot of how you are doing with your diet.

Btw, I'm not picking on anyone.  Someone low fat or with any diet should do the same thing.
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hardrlz

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #24 on: June 22, 2015, 06:05:56 pm »
I also have had glucose tolerance test done and it was normal, however my hbA1C was indicating pre-diabetic condition. The only simple carbs that I eat are fruits and cheese, but i dont think going low carb would fix the problem.

 I already ordered some pregnenolone to see whether there will be some difference in case of possible adrenal fatigue. I will report if there is some change.

PeakT

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #25 on: June 22, 2015, 06:46:50 pm »
I also have had glucose tolerance test done and it was normal, however my hbA1C was indicating pre-diabetic condition. The only simple carbs that I eat are fruits and cheese, but i dont think going low carb would fix the problem.

 I already ordered some pregnenolone to see whether there will be some difference in case of possible adrenal fatigue. I will report if there is some change.

Wait so what carbs are you eating then?  (Cheese has no carbs in it.)
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hardrlz

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #26 on: June 22, 2015, 06:59:49 pm »
Sorry I meant to say the only simple carbs, otherwise i eat complex carbs as well like oats, basmati rice, beans etc.

PeakT

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #27 on: June 22, 2015, 08:31:13 pm »
Sorry I meant to say the only simple carbs, otherwise i eat complex carbs as well like oats, basmati rice, beans etc.

Basmati rice is usually not complex.  You can get it white or brown  If you get the white version, it's a refined carb. And oats really spike the blood sugar of some men.  If you're eating a lot of these and are sensitive to them, which it sounds like you are, then I would reconsider.  In my book, brown rice is the only rice. 

If you're an athlete, you can eat whatever  you want of course just about and struggle to get your calories.  But for the every day guy like you and me, you have be really careful.

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PeakT

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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #28 on: July 25, 2015, 07:37:42 pm »
I split out some discussion on olive oil increasing SHBG via PPAR:

http://www.peaktestosterone.com/forum/index.php?topic=7770.0
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Re: Can Intestinal Issues Take Out the Liver (and SHBG)?
« Reply #28 on: July 25, 2015, 07:37:42 pm »