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Author Topic: Can Progesterone Combat Estradiol in Men?  (Read 5603 times)

xerxes

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Can Progesterone Combat Estradiol in Men?
« on: August 14, 2015, 11:33:54 am »
I've read a few places that progesterone can combat e2. Does anyone have any experience with this?
« Last Edit: August 14, 2015, 03:54:53 pm by PeakT »
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PeakT

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #1 on: August 14, 2015, 05:20:50 pm »
Quote from: xerxes on August 14, 2015, 11:33:54 am
I've read a few places that progesterone can combat e2. Does anyone have any experience with this?

Yes, there is a lot of evidence for this.  Will have more info for you in a bit.
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THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
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If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #1 on: August 14, 2015, 05:20:50 pm »

factor5a

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #2 on: August 14, 2015, 09:01:30 pm »
Yes it does.

I proved it on myself
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54 years

HRT  protocol

62 mgs of Sustenon weekly one IM shot
600 IU HGC  weekly divided in two SQ shots
6 click of  HGH daily
1 ml of Progesteron cream daily
Half pill of Arimidex once a week

Last lab tests

Progesterone,
1.50 ng/mL                                       0.21 - 1.54

Estradiol,
26 pg/mL                                              5 - 66

Testosterone Total

* 989.5 ng/dL                               142.0 - 923.0    ;D

Testosterone Libre (free)

 * 31.0 ng/dL                                     4.0 - 30.0      ;D

Testosterone Biodisponible

* 645.0 ng/dL                                        98.0 - 590.0

Sex Hormone Binding Globulin

 23.4 nmol/L                                              11.2 - 78.1

Albúmin

 3.8 g/dL                                                  3.0 - 5.0

Deaglan

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #3 on: August 15, 2015, 02:33:30 pm »
Yes Progesterone will lower E2 via conversion to Pregnenolone, and it will also lower DHT too. I see some guys going as high as 50mg daily of Progesterone supplementation on TRT; however I don't think it's necessary to take over 15-25mg daily.
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Re: Can Progesterone Combat Estradiol in Men?
« Reply #3 on: August 15, 2015, 02:33:30 pm »

PeakT

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #4 on: August 15, 2015, 03:05:37 pm »
Quote from: Deaglan on August 15, 2015, 02:33:30 pm
Yes Progesterone will lower E2 via conversion to Pregnenolone, and it will also lower DHT too.
Can you say more here? 
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THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
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And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Deaglan

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #5 on: August 15, 2015, 03:46:26 pm »
I'm not really sure how I can elaborate more. It's know that Progesterone is a mild aromatase inhibitor. Since Progesterone converts directly to Pregnenolone, which is a known 5-Ar inhibitor. Progesterone won't work nearly as well as an aromatase inhibitor like Anastrozole, or a supp like DIM/I3C, and I wouldn't use it for that purpose either, but Progesterone will conservativily lower E2 levels.
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PeakT

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #6 on: August 15, 2015, 05:57:38 pm »
Quote from: Deaglan on August 15, 2015, 03:46:26 pm
I'm not really sure how I can elaborate more. It's know that Progesterone is a mild aromatase inhibitor. Since Progesterone converts directly to Pregnenolone, which is a known 5-Ar inhibitor. Progesterone won't work nearly as well as an aromatase inhibitor like Anastrozole, or a supp like DIM/I3C, and I wouldn't use it for that purpose either, but Progesterone will conservativily lower E2 levels.

Okay, I have to look up the pathway chart.  Preg is at the top, so I didn't remember that prog could get fed back upstream.
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THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Sighalot

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #7 on: August 15, 2015, 11:09:41 pm »
Quote from: Deaglan on August 15, 2015, 02:33:30 pm
however I don't think it's necessary to take over 15-25mg daily.
I'd say even that may be over the top and cause accumulation if applied as a cream.
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PeakT

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Re: Can Progesterone Combat Estradiol in Men?
« Reply #8 on: August 15, 2015, 11:18:10 pm »
Deaglan:

Hey, I'm not seeing any feedback from progesterone back up to pregnenalone.  Any chance you were confusing the two?

Check these pathways out:

http://ep.yimg.com/ty/cdn/gentlepharmacy/biosynthesis-of-hormones.html

http://www.propeciahelp.com/forum/viewtopic.php?t=518
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THE MOST COMPREHENSIVE BOOK ON TRT/TESTOSTERONE:
https://www.amazon.com/Natural-Versus-Testosterone-Therapy-Myer/dp/1523210532/ref=sr_1_1?ie=UTF8&qid=1499116128&sr=8-1&keywords=natural+versus+testosterone+therapy
And check out my New Peak Testosterone Program: http://www.peaktestosterone.com/peak_testosterone_program
If you are on medications or have a medical condition, always check with your doctor first before making any lifestyle changes or taking new supplements.  And low testosterone is a medical condition.

Peak Testosterone Forum

Re: Can Progesterone Combat Estradiol in Men?
« Reply #8 on: August 15, 2015, 11:18:10 pm »

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