I have been on HRT March of 2010. In the blood work completed at that time my T level was 254 and estradiol was 33.5. My protocol has been 1ml of 200mg cypinopate per week and Anastozole at various rates. My T levels since starting the injections has ranged in the upper 700's to low1,000's. With blood work completed every 3 - 6 months.
In early December I went in to have a therapeutic and they sent a sample in to do a T & E check because I started using HCG earlier in the year. At the time of the therapeutic I had not had my weekly shot for 2 weeks because my compounding pharmacy was out and were behind on shipments.
My T levels came back at 255 and the E was at 12! So within 2 weeks of no cypinopate injection I was back to baseline.
I didn't feel bad because of the HCG injections earlier in the week, but this definitely proves to me the injections work and you don't want to skip any.