Progesterone is known as a “female hormone,” since it plays a significant role in ovulation, pregnancy and fertility in women. What most men don’t realize is that plasma levels of progesterone are surprisingly high in men and appear to play a significant role in male health. Surprisingly, it can also help some men in the bedroom and many alternative and anti-aging physicians are actually using progesterone to help cure erectile dysfunction and other male-related health issues, something I will discuss below.
Although progesterone therapy has certainly not gone mainstream in men, it certainly has many impressive benefits, which are outlined below. Again, here are some reasons progesterone is growing in popularity for middle-aged and beyond men:
CAUTION: Progesterone should only be administered under the care of a knowledgeable physician. Not everyone feels good on progesterone. One man wrote that “I tried using a very small amount of progesterone cream but even the recommended small amount for men made me feel lousy the following morningm so I stopped using it after only a few days.”  In addition, please read my page on The Potential Dangers of Progesterone for additional important information.
1. 5-Alpha-Reductase Inhibition. This enzyme is responsible for converting testosterone into DHT. DHT is a powerful hormone in males and is responsible in part for libido, muscle growth and many other male functions. However, too much DHT can be hard on the prostate and lead to hair loss. Progesterone, which decreases with aging, is a significant inhibitor of 5-alpha reductase. 
2. Erectile Dysfunction Treatment. There are some anecdotal reports, admittedly from non-peer reviewed sources, that indicate that progesterone can be a near miraculous cure for some men with erectile dysfunction, especially when combined with HRT (testosterone therapy). I cover this in my page on Progesterone and Erectile Dysfunction.
3. Noradrenaline Control and Reduction. It looks progesterone can help control and even reduce noradrenaline.  This stress hormone is known for being the “anti-erection” hormone in the sense that it actually provides necessary feedback from men getting spontaneous erections. However, too much noradrenaline puts the brakes on one’s hardness factor.
NOTE: Are you high or low in progesterone? You can find out yourself through one of these Testosterone and Hormone Labs.
4. High Blood Pressure. Progesterone, likely from the effects of #2, can improve blood pressure a little in men and, of course, hypertension is one of the leading risk factors for erectile dysfunction.  For more information, see this link on High Blood Pressure and Erectile Dysfunction.
5. Sleep Improvement. Progesterone plays an important role in sleep and sleep quality.  Some commentators believe this is progesterone’s primary role, because Sleep is So Critical to Male Health.
7. Fertility. Sperm hyperactivation may not sound like a good thing, but it’s actually important in order for the egg to be fertilized. Progresterone is actually one of the major factors responsible for this.  You can get your levels checked at one of these Man Friendly Labs.
NOTE: One of the Peak Testosterone Forum members reported that progesterone restroed the size of his testes:  “As a side note, (just thought about this ), I do have a fair amount of testicular atrophy going on because I was so low testosterone for so many years. I found that using progesterone cream stopped the atrophy. You can find more about this by googleing men and progesterone.” However, the above does not make sense to me and was contradicted by an animal study. 
DOSAGES: The dose that physicians seem to be using is based on a couple of reports that I have received on the Peak Testosterone Forum and are in the 10-50 mg/day range when it comes to the creams. Again, I do not know about long term safety and nor does anyone else, but here is what these men reported:
“I use Source Naturals natural progesterone cream, which has 500 mg progesterone per ounce, or 22 mg per 1/4 teaspoon. I use about 1/4 teaspoon twice a day. Don’t go by the instructions on the package, as these are for perimenopausal women. I use it every day without a break.” 
“I have been discussing a progesterone/Testosterone compound with my physician. He states that he has many of his patients on a compounded cream of prog/test (10mg/50mg daily) from a pharmacy in town. He said that the progesterone will help block some of the estrogen, therefore blocking some estrogen side effects.” 
1) Psychoneuroendocrinology, Apr 2004, 29(3):339 354, “Administration of progesterone produces mild sedative-like effects in men and women”
2) The Journal of Clinical Endocrinology & Metabolism, Jan 1 1974, 38(1):142-147, “Inhibition of Testosterone Conversion to Dihydrotestosterone in Men Treated Percutaneously by Progesterone”
3) Clin Endocrinol (Oxf), 1980 Nov, 13(5):409-12, “Leydig cell tumour of the testis with gynaecomastia and elevated oestrogen, progesterone and prolactin levels: case report”
4) Plast Reconstr Surg, 2000 Oct, 106(5):1011-3, “Estrogen and progesterone receptors in gynecomastia”
5) Gynecol Obstet Invest, 1993, 36:234 238, “Progesterone Reduces Sympathetic Tone without Changing Blood Pressure or Fluid Balance in Men”
6) Br Med J (Clin Res Ed), 1985 Jan 5, 290(6461):13 14.”Natural progesterone and antihypertensive action”
7) The Aging Male, 2004, Vol. 7(3):236-257, “Progesterone: the forgotten hormone in men?”
11) J Endocrinol. 1981 Jul;90(1):97-102, “Effects of testosterone, pregnenolone, progesterone and cortisol on pituitary and testicular function in male golden hamsters with gonadal atrophy induced by short photoperiods”
12) Fertility and Sterility, 1992, 58(6):1191-1198, “Direct effects of progesterone and antiprogesterone on human sperm hyperactivated motility and acrosome reaction”