hand with pen drawing the chemical formula of Estrogen

Testosterone-to-Estrogen Ratio

Remember those chem lab days?  Well, if you do, you may remember that sometimes the concentration of a solvent or chemical is more important than the absolute amount of the same.  What I remember even more is getting kicked solidly in the right buttock by my 8th grade chem teacher for goofing around with chemicals in the laboratory, but that’s another story.Again, though, the concentration is often critical and this hold true in the hormonal world as well.  For example, researchers recently found that it is the ratio of testosterone to estrogen that determines prostate cancer health more than total testosterone.

So what is a good T/E ratio?  A solid number for a 20 year old male is 30-40 with some guys shooting near 50.  Of course, some would argue that a T/E ratio that high makes it to where most guys can’t think straight.  Regardless, youthful testosterone-to-estradiol ratios are quite high and are certainly ideal in terms of maintaining male health.

NOTE:  Estradiol is the most powerful estrogen in us guys and is termed E2.  Most testosterone-to-estrogen ratios are actually testosterone-to-estradiol ratio in the literature from what I have read, and I use them interchangeably below.

1) The Journal of Sexual Medicine, Jul 2006, 3(4):716-722, “Testosterone:Estradiol Ratio Changes Associated with Long-Term Tadalafil Administration: A Pilot Study”

2) Systems Biology in Reproductive Medicine, 2006, 52(2):97-102, “EFFECT OF BODY WEIGHT ON TESTOSTERONE/ESTRADIOL RATIO IN OLIGOZOOSPERMIC PATIENTS”3) Int J Sport Nutr Exerc Metab, 2008 Apr, 18(2):131-41, “Dose effect of caffeine on testosterone and cortisol responses to resistance exercise”

3) Am J Med, 1985 Jan, 78(1):23-7, “Effects of a high-complex-carbohydrate, low-fat, low-cholesterol diet on levels of serum lipids and estradiol”

4) Clin Endocrinology, 2009, vol. 70(1)”116-123, “Effects of aromatase inhibition in hypogonadal older men : a randomized, double-blind, placebo-controlled trial”

5) The Journal of Urology, Feb 2002, 167(1):624-629, “AROMATASE INHIBITORS FOR MALE INFERTILITY”

6) Indian J Clin Biochem, 2015 Jan, 30(1):59-65, “Serum Testosterone, 17β-Estradiol and PSA Levels in Subjects with Prostate Disorders”

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